Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease

Patel, Arsheya; Krishna, Somashekar G.; Patel, Kishan; Gray, Darrell M.; Mumtaz, Khalid; Stanich, Peter P.; Hinton, Alice; Hussan, Hisham

doi:10.1007/s10620-022-07589-3

Cited by 3 publications

(4 citation statements)

References 44 publications

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“…Approximately 60% of those above the age of 60 have diverticulosis coli [1] and approximately 4% develop diverticulitis [2]. Also, the incidence of diverticulitis is increasing in the younger population [3]. The pathophysiology of diverticulitis is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Diverticulitis Is Associated with Increased Risk of Colon Cancer—A Nationwide Register-Based Cohort Study

Mortensen,

Andresen,

Thygesen

et al. 2024

JCM

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Background: An association between diverticulitis and colon cancer has been proposed. The evidence is conflicting, and the guidelines differ regarding recommended follow-up with colonoscopy after an episode of diverticulitis. To guide regimes for follow-up, this study aimed to investigate if patients with diverticulitis have an increased risk of colon cancer. Methods: This study is reported according to the RECORD statement. We performed a cohort study with linked data from nationwide Danish registers. The inclusion period was 1997–2009, and the complete study period was 1995–2013. The primary outcome was the risk of developing colon cancer estimated using a Cox regression analysis with time-varying covariates. We performed a sensitivity analysis on a cohort of people with prior colonoscopies, comparing the risk of colon cancer between the diverticulitis group and the control group. Results: We included 29,173 adult males and females with diverticulitis and 145,865 controls matched for sex and age. The incidence proportion of colon cancer was 2.1% (95% confidence interval (CI) 1.9–2.3) in the diverticulitis group and 1.5% (95% CI 1.4–1.5) in the matched control group (hazard ratio 1.6; 95% CI 1.5–1.8). The risk of having a colon cancer diagnosis was significantly increased in the first six months after inclusion (hazard ratio 1.7; 95% CI 1.5–1.8), and hereafter there was a lower risk in the diverticulitis group compared with controls (hazard ratio 0.8; 95% CI 0.7–0.9). This protective effect lasted eight years. The increased risk of colon cancer during the first six months after diverticulitis was also found in the cohort with prior colonoscopies. Conclusions: The risk of a colon cancer diagnosis was significantly increased for patients with diverticulitis 0–6 months after the diagnosis of diverticulitis. Hereafter, we found a protective effect of diverticulitis until eight years later, possibly due to a screening effect. We recommend a follow-up colonoscopy after the first diagnosis of diverticulitis.

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Section: Introductionmentioning

confidence: 99%

Diverticulitis Is Associated with Increased Risk of Colon Cancer—A Nationwide Register-Based Cohort Study

Mortensen,

Andresen,

Thygesen

et al. 2024

JCM

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“…Furthermore, obesity is projected to affect 50% of the U.S. population by 2030, which can in turn worsen obesity‐linked gastrointestinal conditions 3 . Indeed, we recently identified an increasing trend of admissions for infectious or inflammatory gastrointestinal conditions with the rise of severe obesity in young adults 4 . In that regard, bariatric surgery is a safe and effective long‐term treatment option for patients with obesity who fail medical therapy 5–7 .…”

Section: Introductionmentioning

confidence: 99%

“…3 Indeed, we recently identified an increasing trend of admissions for infectious or inflammatory gastrointestinal conditions with the rise of severe obesity in young adults. 4 In that regard, bariatric surgery is a safe and effective long-term treatment option for patients with obesity who fail medical therapy. [5][6][7] Vertical sleeve gastrectomy (VSG) has been the most utilized bariatric surgery over the last decade, followed by Roux-en-Y gastric bypass (RYGB).…”

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confidence: 99%

The impact of bariatric surgery on admissions for gastrointestinal complications and conditions associated with obesity: A nationwide study

Patel,

Abu Dayyeh,

Balasubramanian

et al. 2023

World j. surg.

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BackgroundObesity worsens various gastrointestinal pathologies. While bariatric surgery ameliorates obesity, it substantially modifies the gastrointestinal system depending on surgery type, with limited data on subsequent impact on obesity‐related gastrointestinal admissions.MethodsUsing the 2012–2014 Nationwide Readmission Database, we included individuals with obesity who received vertical sleeve gastrectomy (VSG), Roux‐en‐Y gastric bypass (RYGB), or hernia repair (HR–control surgery). Our main focus was the adjusted odds ratio (aOR) for gastrointestinal inpatient admissions within 6 months following surgery compared to the 6 months preceding it, while controlling for several confounding factors. Gastrointestinal admissions were grouped into postoperative complications or obesity‐associated gastrointestinal conditions.ResultsOur cohort included 140,103 adults with RYGB, 132,253 with VSG, and 12,436 HR controls. Postoperative gastrointestinal complications were most common after RYGB, prominently obstruction (aOR = 33.17, 95%CI: 18.01, 61.10), and Clostridium difficile infection (aOR: 12.52, 95%CI: 6.22, 25.19). VSG also saw significantly increased but less frequent similar conditions. Notably, for gastrointestinal conditions associated with obesity, acute pancreatitis risk was higher post‐VSG (aOR = 6.26, 95%CI: 4.02, 9.73). Post‐RYGB patients were most likely to be admitted for cholelithiasis with cholecystitis (aOR: 4.15, 95% CI: 3.24, 5.31), followed by chronic liver disease (aOR: 3.00, 95% CI: 2.33, 3.87). The risk of noninfectious colitis admissions was threefold higher after RYGB and VSG. No gastrointestinal conditions showed an increase after HR.ConclusionDespite weight loss, bariatric surgery was associated with an increased risk of hepato‐pancreatobiliary and colitis admissions related to obesity in the first six postoperative months, with considerable variations in rates of gastrointestinal conditions by surgery type.

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“…The data appear to be quite obscure; nevertheless, the association between the body mass status and IBD is undeniable. A significant role in this area is played by adipose tissue and adipokines released by this organ [ 25 , 26 , 27 , 28 ]. Thus, we decided to perform a review of available literature on the involvement of obesity and adipose tissue in the modulation of metabolic and inflammatory background in IBD, giving special attention to their role in the treatment and general management of affected patients.…”

Section: Introductionmentioning

confidence: 99%

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

Michalak

Kasztelan-Szczerbińska

Cichoż‐Lach

2022

Nutrients

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It is already well-known that visceral adipose tissue is inseparably related to the pathogenesis, activity, and general outcome of inflammatory bowel disease (IBD). We are getting closer and closer to the molecular background of this loop, finding certain relationships between activated mesenteric tissue and inflammation within the lumen of the gastrointestinal tract. Recently, relatively new data have been uncovered, indicating a direct impact of body fat on the pattern of pharmacological treatment in the course of IBD. On the other hand, ileal and colonic types of Crohn’s disease and ulcerative colitis appear to be more diversified than it was thought in the past. However, the question arises whether at this stage we are able to translate this knowledge into the practical management of IBD patients or we are still exploring the scientific background of this pathology, having no specific tools to be used directly in patients. Our review explores IBD in the context of obesity and associated disorders, focusing on adipokines, creeping fat, and possible relationships between these disorders and the treatment of IBD patients.

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Rising Rates of Severe Obesity in Adults Younger Than 50 Correspond to Rise in Hospitalizations for Non-malignant Gastrointestinal Disease

Cited by 3 publications

References 44 publications

Diverticulitis Is Associated with Increased Risk of Colon Cancer—A Nationwide Register-Based Cohort Study

Diverticulitis Is Associated with Increased Risk of Colon Cancer—A Nationwide Register-Based Cohort Study

The impact of bariatric surgery on admissions for gastrointestinal complications and conditions associated with obesity: A nationwide study

Impact of Obesity on the Course of Management of Inflammatory Bowel Disease—A Review

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