Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades

Hong, Angela; Lee, C. Soon; Jones, D. Brian; Veillard, Anne Sophie; Zhang, Mei; Zhang, Xiaoying; Smee, Robert; Corry, June; Porceddu, Sandro; Milross, Christopher G.; Elliott, Michael; Clark, Jonathan; Rose, Barbara

doi:10.1002/hed.23942

Cited by 84 publications

(91 citation statements)

References 28 publications

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“…Consistent with this conclusion, a series of 520 consecutive OPC patients presenting to 10 Australian hospitals from 1985‐2010 also showed an increase in the HPV‐positive rate of OPC from 20.2% in 1987‐1995 to 63.5% in 2006‐2010. Uniform testing for HPV‐status in this study supports the notion that observed increases in HPV‐AF are not a result of improvements in viral detection …”

Section: Resultsmentioning

confidence: 99%

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

Faraji

Eisele

Fakhry

2017

Laryngoscope Investig Oto

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ObjectiveTo review recent literature on human papillomavirus‐related (HPV‐positive) oropharyngeal squamous cell carcinoma (OPC) and focus on implications of recurrent and metastatic disease.MethodsPrimary articles from 1990 to 2016 indexed in MEDLINE (1) pertaining to the epidemiology of HPV‐positive OPC and (2) providing clinical insight into recurrent and metastatic OPC.ResultsThe incidence of HPV‐positive OPC is increasing globally. HPV‐positive OPC is a subtype with distinct molecular and clinical features including enhanced treatment response and improved overall survival. While disease recurrence is less common in patients with HPV‐positive OPC, up to 36% of patients experience treatment failure within eight years. Recurrent and metastatic OPC has historically signified poor prognosis, however recent data are challenging this dogma. Here, we discuss recurrent and metastatic OPC in the context of HPV tumor status.ConclusionHPV‐positive OPC exhibits distinct genetic, cellular, epidemiological, and clinical features from HPV‐negative OPC. HPV tumor status is emerging as a marker indicative of improved prognosis after disease progression in both locoregionally recurrent and distant metastatic OPC.Level of EvidenceN/A.

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Section: Resultsmentioning

confidence: 99%

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

Faraji

Eisele

Fakhry

2017

Laryngoscope Investig Oto

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“…We focused our study on patients with carcinoma of the tonsil, the subsite of oropharyngeal cancer with the highest HPV positivity rate, to limit the variation in prognosis among tumors involving different subsites of the oropharynx [1, 2]. We found a strong correlation between HPV positivity and PD-L1 expression (83.3% vs 56.9%, p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Human papillomavirus (HPV) is implicated in the majority (up to 70%) of OSCC in the western world with the tonsillar subsite associated with the highest HPV positivity rate [1, 2]. HPV+positive OSCC demonstrates favorable prognosis due to improved response to therapy [3–7].…”

Section: Introductionmentioning

confidence: 99%

PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-PD1 clinical trials

et al. 2016

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In this study, we examined PD-L1 expression by immunohistochemistry in 99 patients with tonsillar cancer and known human papillomavirus (HPV) status to assess its clinical significance. We showed that the pattern of PD-L1 expression is strongly related to HPV status. The PD-L1 positivity rate was 83.3% in HPV-positive cases and 56.9% in HPV-negative cases (p < 0.05). Patients with HPV-positive/PD-L1-positive cancer had significantly better event free survival and overall survival compared with patients with HPV-negative/PD-L1-negative cancer. Relative to those patients with HPV-negative/PD-L1-negative disease who had the highest risk of death, patients with HPV-positive/PD-L1-positive cancers had a 2.85 fold lower risk of developing an event (HR 0.35, 95% CI: 0.16–0.79) and a 4.5 fold lower risk of death (HR =0.22, 95% CI: 0.09–0.53). Our findings will help to guide future clinical trial design in immunotherapy based on PD-L1 expression in tonsillar cancer.

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“…Global incidence rates of oropharyngeal cancer (OPC) are rising, particularly in economically developed countries such as Canada, United States, Japan, Switzerland, Australia, England and parts of Eastern Europe [3][4][5][6][7]. Rates of oral cavity cancer (OCC) are also rising among men and women in some European countries, stabilising in certain Asian countries and decreasing in Canada and USA [4,8].…”

Section: Introductionmentioning

confidence: 99%

Trends of oral cavity, oropharyngeal and laryngeal cancer incidence in Scotland (1975–2012) – A socioeconomic perspective

et al. 2016

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Aim: To examine current incidence trends of oral cavity (OCC), oropharyngeal (OPC) and laryngeal cancer in Scotland by socioeconomic status (SES). Methods:We included all diagnosed cases of OCC (C00.3-C00.9, C02-C06 excluding C2. rates increased markedly for OPC, decreased for laryn-geal cancer and remained stable for OCC, particularly in the last decade. Males exhibited significantly higher RRs compared to females, and the peak age of incidence of OPC was slightly lower than the other subsites. Conclusion:Contrary to reports that OPC exhibits an inverse socioeconomic profile, Scotland country-level data show that those from the most deprived areas consistently have the highest rates of head and neck cancers.3

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Rising prevalence of human papillomavirus–related oropharyngeal cancer in Australia over the last 2 decades

Abstract: Our data show a rising prevalence of HPV-positive oropharyngeal SCC in Australia over the last 2 decades. These patients with HPV-positive oropharyngeal SCC are now presenting at an older age and about one third have never smoked.

Cited by 84 publications

References 28 publications

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

Emerging insights into recurrent and metastatic human papillomavirus‐related oropharyngeal squamous cell carcinoma

PD-L1 expression in tonsillar cancer is associated with human papillomavirus positivity and improved survival: implications for anti-PD1 clinical trials

Trends of oral cavity, oropharyngeal and laryngeal cancer incidence in Scotland (1975–2012) – A socioeconomic perspective

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