Rising incidences of Warthin’s tumors may be linked to obesity: a single-institutional experience

Kadletz, Lorenz; Grasl, Stefan; Perisanidis, Christos; Grasl, Matthäus C.; Erović, Boban M.

doi:10.1007/s00405-019-05319-6

Cited by 26 publications

(21 citation statements)

References 17 publications

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“…This study [7] suggests the occurrence of a shift in the prevalence of benign parotid gland tumors, Warthin's tumor becoming the most common. The same study [7] reported a significantly higher BMI of patients with WT in comparison with other parotid gland neoplasms. Furthermore, a link was observed between being overweight/obese and tumor size.…”

Section: Discussionmentioning

confidence: 66%

“…This study also found WT to be the most common histological parotid gland tumor between 1997 and 2017, while also observing a decrease of patients' age from 68 to 62 years. Kadletz et al [7] evaluated 919 patients treated for benign parotid gland tumors and reported a rising incidence WT, from 9.1% in the early 1960s, to 50% in 2000s and 60.6% in 2015. This study [7] suggests the occurrence of a shift in the prevalence of benign parotid gland tumors, Warthin's tumor becoming the most common.…”

Section: Discussionmentioning

confidence: 99%

“…Kadletz et al [7] evaluated 919 patients treated for benign parotid gland tumors and reported a rising incidence WT, from 9.1% in the early 1960s, to 50% in 2000s and 60.6% in 2015. This study [7] suggests the occurrence of a shift in the prevalence of benign parotid gland tumors, Warthin's tumor becoming the most common. The same study [7] reported a significantly higher BMI of patients with WT in comparison with other parotid gland neoplasms.…”

Section: Discussionmentioning

confidence: 99%

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Unilateral Deforming Warthin’s Tumor: Case Report and Literature Review

et al. 2020

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Warthin’s tumor (WT) is the second most common benign tumor of the parotid gland. Located almost exclusively in the parotid gland and presenting a slow growth rate, WT usually does not exceed 4 cm and rarely benefits from early surgical treatment. The aim of this paper is to present a case of giant parotid Warthin’s tumor. The occurrence of large and deforming WT is rare, previous research showed a single similar reported case. The patient’s computed tomography scans showed a solid and cystic 15 × 13 cm2 mass of the parotid gland, without visible signs of invading the adjacent structures. Superficial parotidectomy with tumor excision was performed, with preservation of glandular and facial nerve functions. The paper also presents a brief literature review addressing the main controversies regarding etiopathology, epidemiology, diagnostic methods and treatment options for this parotid gland tumor.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Unilateral Deforming Warthin’s Tumor: Case Report and Literature Review

et al. 2020

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“…The incidence of Warthin tumors has increased steadily over the years. 29,30 The imaging modalities have improved, and more patients are susceptible to have imaging for various reasons, leading to incidental findings also in the parotid gland. In our cohort, 40% of patients (n = 24)…”

Section: Discussionmentioning

confidence: 99%

Preoperative evaluation and treatment consideration of parotid gland tumors

Aro

Korpi

Tarkkanen

et al. 2020

Laryngoscope Investig Oto

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Background The nature of parotid tumors often remains unknown preoperatively and final histopathology may reveal unexpected malignancy. Still, the use of fine‐needle aspiration cytology (FNAC) and imaging varies in the management of these tumors. Methods We evaluated the preoperative examinations and management of all 195 parotid gland tumors diagnosed within our catchment area of 1.6 million people during 2015. Results Altogether 171 (88%) tumors were classified as true salivary gland neoplasms. FNAC showed no false malignant findings, but it was false benign in 5 (2.6%) cases. Preoperative MRI was utilized in 48 patients (25%). Twenty (10%) malignancies included 16 salivary gland carcinomas. Pleomorphic adenomas accounted for 52% of all adenomas. For 24 (40%) Warthin tumors, surgery was omitted. Conclusion The proportion of malignancies was lower than generally presented. Our proposed guidelines include ultrasound‐guided FNAC with certain limitations. MRI is warranted in selected cases, but seems unnecessary routinely.

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“…Warthin tumor is commonly seen in smokers, and presentation as a bilateral/ multifocal tumor is an additional characteristic feature [6]. A recent association with obesity has been reported; showing a significant higher body mass index (BMI) in patients with Warthin tumor compared to other benign parotid gland tumors [7].…”

Section: Introductionmentioning

confidence: 99%

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

Zaccarini

Khurana

2019

Head and Neck Pathol

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Warthin tumor is the second most common benign parotid neoplasm. Its association with non-salivary gland neoplasms has been sporadically reported. We reviewed clinical records of Warthin tumor diagnosed on aspiration cytology and surgical pathology to determine if there is any association with other extra-salivary gland malignant neoplasms. Computer search was made for all cases of Warthin tumor diagnosed in the parotid gland by aspiration cytology and surgical pathology at our institution between January 2007 and August 2016. Clinical records of all cases were reviewed for any associated malignant neoplasms and any surgical follow up. All available cytology and histologic material was reviewed. Seventy-three patients (mean 66.9, M:F 1.1:1, age range 43 to 87 years) with Warthin tumor were identified. 45 (62%) were diagnosed on aspiration cytology only, 19 (26%) had cytologic diagnosis as well as concordant surgical follow up, and 9 (12%) were diagnosed based on surgical pathology only. Average age for patients with and without secondary malignancy was 70.5-years, and 63.4-years, respectively (p < 0.05). Average pack years for patients with and without secondary malignancy was 45.4, and 39.8, respectively (p > 0.05). Twenty-seven (37.0%) patients harbored a malignant neoplasm. Association of extra salivary gland malignant neoplasms in 37.0% of our cases suggest that the prevalence of secondary non-salivary neoplasms in patients harboring Warthin tumor might have been underestimated. Squamous cell carcinoma was the most commonly associated non-salivary malignant neoplasm. The association of Warthin tumor with smoking plays an important role in this increased rate of malignancy, and this is supported by the fact that smoking is highly associated with head and neck and lung cancers.

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Rising incidences of Warthin’s tumors may be linked to obesity: a single-institutional experience

Cited by 26 publications

References 17 publications

Unilateral Deforming Warthin’s Tumor: Case Report and Literature Review

Unilateral Deforming Warthin’s Tumor: Case Report and Literature Review

Preoperative evaluation and treatment consideration of parotid gland tumors

Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases

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