Rising from the ashes: cellular senescence in regeneration

Walters, Hannah; Yun, Maximina H.

doi:10.1016/j.gde.2020.06.002

Cited by 30 publications

(30 citation statements)

References 58 publications

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“…Multiple stimuli can aggravate cellular senescence and in response a senescence-associated secretory phenotype (SASP) secretes high concentrations of proteins cells and cytokines. This particular phenotype is associated with senescent cells wherein they secrete high levels of inflammatory cytokines (e.g., IL-1, IL-6, IL-8), growth factors (e.g., TGF-β, HGF, VEGF, PDGF), MMPs, and cathepsins [165]. SAPS has been shown to increase with age, as homeostatic processes are disrupted leading to cell senescence and reduced regenerative capacity when compared to younger adults.…”

Section: Effects Of Aging and Cell Senescencementioning

confidence: 99%

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Everts

Onishi²,

Jayaram

et al. 2020

IJMS

497

319

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Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling). Many different PRP formulations have been evaluated, originating from human, in vitro, and animal studies. However, recommendations from in vitro and animal research often lead to different clinical outcomes because it is difficult to translate non-clinical study outcomes and methodology recommendations to human clinical treatment protocols. In recent years, progress has been made in understanding PRP technology and the concepts for bioformulation, and new research directives and new indications have been suggested. In this review, we will discuss recent developments regarding PRP preparation and composition regarding platelet dosing, leukocyte activities concerning innate and adaptive immunomodulation, serotonin (5-HT) effects, and pain killing. Furthermore, we discuss PRP mechanisms related to inflammation and angiogenesis in tissue repair and regenerative processes. Lastly, we will review the effect of certain drugs on PRP activity, and the combination of PRP and rehabilitation protocols.

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Section: Effects Of Aging and Cell Senescencementioning

confidence: 99%

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

Everts

Onishi²,

Jayaram

et al. 2020

IJMS

497

319

View full text Add to dashboard Cite

show abstract

“…12 It is also possible that the induction of senescent cells which recurrently takes place during limb regeneration 49 also contributes to regulate macrophage recruitment dynamics-and perhaps macrophage functions-as the latter are recruited to the former in salamander tissues, much like it happens in mammals. 52 Notably, a number of studies have revealed critical roles for macrophages in axolotl limb 17,49 and heart regeneration, 7 and newt (N viridescens and Cynops pyrroghaster) lens regeneration. In these contexts, macrophages have been hypothesized to regulate a number of processes, including inflammatory signaling, wound epithelialization, vascularization, local proliferation and matrix remodeling, for example through production of matrix metalloproteases such as MMP3.…”

Section: Macrophage Recruitment During Regenerationmentioning

confidence: 99%

“…Knock‐down of this interleukin leads to reduced myeloid cell retention and delayed limb regeneration 12 . It is also possible that the induction of senescent cells which recurrently takes place during limb regeneration 49 also contributes to regulate macrophage recruitment dynamics—and perhaps macrophage functions—as the latter are recruited to the former in salamander tissues, much like it happens in mammals 52 …”

Section: Innate Immune Cells In Regenerationmentioning

confidence: 99%

Immunity in salamander regeneration: Where are we standing and where are we headed?

Bolaños-Castro

Walters

Vazquez

et al. 2020

Developmental Dynamics

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Salamanders exhibit the most extensive regenerative repertoire among vertebrates, being able to accomplish scar-free healing and faithful regeneration of significant parts of the eye, heart, brain, spinal cord, jaws and gills, as well as entire appendages throughout life. The cellular and molecular mechanisms underlying salamander regeneration are currently under extensive examination, with the hope of identifying the key drivers in each context, understanding interspecies differences in regenerative capacity, and harnessing this knowledge in therapeutic settings. The immune system has recently emerged as a potentially critical player in regenerative responses. Components of both innate and adaptive immunity have been found at critical stages of regeneration in a range of salamander tissues. Moreover, functional studies have identified a requirement for macrophages during heart and limb regeneration. However, our knowledge of salamander immunity remains scarce, and a thorough definition of the precise roles played by its members is lacking. Here, we examine the evidence supporting roles for immunity in various salamander regeneration models. We pinpoint observations that need revisiting through modern genetic approaches, uncover knowledge gaps, and highlight insights from various model organisms that could guide future explorations toward an understanding of the functions of immunity in regeneration.

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“…The timely and spatially controlled induction of senescence is part of a developmental program where the secretory function of senescent cells serves to fine-tune cell fate determination and tissue patterning (10). In highly regenerative organisms, e.g., salamanders and zebrafish, senescent cells contribute to the regeneration of complex structures (11). A recent report suggests the presence of senescent fibroblasts in the developing and adult lung supporting epithelial progenitor cell function (12).…”

Section: Senescence In Repair and Developmentmentioning

confidence: 99%