Risikobewertung von Zytologiebefunden im Zervixkarzinom-Screening

Marquardt, Katrin; Ziemke, Peter; Neumann, Konrad; Kühn, W

doi:10.1007/s00129-019-04536-8

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…2 The exact course also depends on additional factors like age, persistence of high-risk HPV types, and further risk factors. 24 – 27 Hence, to prevent over-treatment of low-grade abnormalities, testing for hr-HPV is often included in screening strategies 2 , 28 , 29 to estimate the risk for the occluded presence or potential progression to higher-level lesions. However, screening for HPV is particularly recommended for older women 2 as hr-HPV persistent is more significant in older women.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite

Huber

Mueller²,

Sailer³

et al. 2021

Womens Health (Lond Engl)

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Cervical cancer, the third most common cancer in women, is caused in nearly all cases by a persistent infection with high-risk types of the human papillomavirus. Although human papillomavirus infections are 80%–90% transient and disappear spontaneously within 24 months, human papillomavirus infections that remain are at risk of developing cervical lesions. Different therapeutical approaches have been tested to promote the regression of low-grade lesions or prevent progression. They include the application of 5-fluorouracil, curcumin, imiquimod, interferons, Vitamin D, and others. Also, the effect of probiotics and vaginal therapy with carboxy-methyl-beta glucan was assessed. Review of the literature and presentation of the last study data are presented. Clearance of high-risk human papillomavirus seemed to be promoted by treatment with a new vaginal gel containing a highly disperse SiO2 and an anti-oxidative combination of citric acid and sodium. This gel showed, after 6 months, an improvement of cytological Pap findings (ASC-US, LSIL, ASC-H, or HSIL) in 80.9% of the participants. Similarly, there was a clearing of hr-human papillomavirus in 53% of cases after 3 months of gel administration. The percentage increased slightly in the non-treated control group from 78.3% at baseline to 83% after 3 months. The percentage of patients who were tested positive for p16/Ki67 reduced from 75% at baseline to 5.3% in the treatment group after 6 months, while the percentage decreased only slightly in the non-treated group (baseline: 91.5%; 6 months: 75.2%). The examined vaginal gel may support the healing of conspicuous cytological findings (ASC-US, LSIL, ASC-H, or HSIL) and clearance of hr-human papillomavirus positive results.

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite

Huber

Mueller²,

Sailer³

et al. 2021

Womens Health (Lond Engl)

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“…Зміни низького ступеня злоякісності, такі, як ASC-US (атипові клітини плоского епітелію нез'ясованого генезу) і LSIL (слабовиражене плоскоклітинне інтраепітеліальне ураження), досить часто можуть спонтанно регресувати до нормального стану протягом 1-2 років, однак в інших випадках відбувається прогресування до більш тяжких станів, що характеризують як цервікальну інтраепітеліальну неоплазію 2-го і 3-го типів (ЦІН 2/3) [4,5]. Шлях розвитку таких змін залежить від додаткових факторів, наприклад, віку, наявності штамів ВПЛ з високим ризиком, а також інших чинників ризику [6][7][8][9][10].…”

Section: з а р у б і ж н і д о с л і д ж е н н яunclassified

“…У літературі можна знайти дані, які свідчать про те, що за шість місяців регресує 50% ASC-US i LSIL, однак цей процес може тривати до 26 місяців [10]. При цьому прогресія до ЦІН 2+ спостерігається у 10-29% випадків [7,20,24]. Персистенція ASC-US або LSIL свідчить про значне зростання ризику розвитку диспластичних перетворень у майбутньому [7,8,22].…”

Section: обговоренняunclassified

“…При цьому прогресія до ЦІН 2+ спостерігається у 10-29% випадків [7,20,24]. Персистенція ASC-US або LSIL свідчить про значне зростання ризику розвитку диспластичних перетворень у майбутньому [7,8,22]. Через це корисним є сприяння регресії таких змін.…”

Section: обговоренняunclassified

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Treatment with an intravaginal gel containing siliceous dioxide, selenite, and citric acid to promote regression of ASC-US, LSIL, ASC-H, HSIL, p16/Ki67 status and improve clearance of hr-HPV in cervical specimens

Mueller¹,

Sailer²,

Regidor³

2021

RHW

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Objective: An intravaginal gel containing highly dispersed silicon dioxide (SiO2) and an anti-oxidative combination of citric acid and sodium selenite was tested for its ability to promote regression of abnormal cytological findings and its influence on hr-HPV status and tumor markers p16/Ki67 (CINtec® PLUS test).Patients and methods: A control study was performed, including women (n=100) diagnosed with conspicuous cervical smears (ASC-US, LSIL, ASC-H, or HSIL). The gel was applied for 3x28 days. After three months, participants were analyzed for Pap status, hr-HPV strains, and expression of tumor markers p16/Ki67. Three months later, Pap testing and p16/Ki67 analysis were repeated. The results were compared to those of 106 women who met the same inclusion criteria but did not obtain any treatment.Results: After six months, cytological Pap findings were improved in 80.9% of the participants in the treated group, and the clearing of hr-HPV was observed in 53% of cases. Only 5.3% were tested p16/Ki67 positive after six months in comparison to 75.0% at baseline. In the comparison group, 37.1% of the Pap smears and 18.6% of the CinTec results were improved, but no hr-HPV clearance was observed. The improvements were highly significant for the treatment. Conclutions: The vaginal gel containing SiO2 sodium selenite, and citric acid may support the healing of conspicuous cytological findings and clearance of hr-HPV.

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Biopsien im Zervixkarzinomscreening: Wert und Wirkung

Ziemke

Marquardt

2021

Gynäkologe

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Risikobewertung von Zytologiebefunden im Zervixkarzinom-Screening

Cited by 4 publications

References 22 publications

Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite

Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite

Treatment with an intravaginal gel containing siliceous dioxide, selenite, and citric acid to promote regression of ASC-US, LSIL, ASC-H, HSIL, p16/Ki67 status and improve clearance of hr-HPV in cervical specimens

Biopsien im Zervixkarzinomscreening: Wert und Wirkung

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