Rise of The Nanomachine: The Evolution of A Revolution in Medicine

Park, Hye Hun; Jamison, Andrew C.; Lee, T Randall

doi:10.2217/17435889.2.4.425

Cited by 15 publications

(8 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With advances in society comes a growing need for a reduction in the size and energy needs of devices, especially in the emerging fields of nanoelectronics and nanomedicine . Thus, control over the nature of the surfaces of devices becomes an issue of prime importance in many technologies. , What better strategy to follow than that of nature? In vivo, molecules self-assemble to form diverse complex structures that exhibit important mechanical properties (e.g., collagen in skin and bone) or produce energy or matter (e.g., photosynthesis or DNA replication).…”

Section: Introductionmentioning

confidence: 99%

SAMs on Gold Derived from the Direct Adsorption of Alkanethioacetates Are Inferior to Those Derived from the Direct Adsorption of Alkanethiols

et al. 2009

View full text Add to dashboard Cite

Self-assembled monolayers (SAMs) on gold derived from the direct adsorption of thioacetic acid S-decyl ester (C10SAc) and thioacetic acid S-octadecyl ester (C18SAc) were compared to the corresponding SAMs derived from the analogous adsorption n-decanethiol (C10SH) and n-octadecanethiol (C18SH). All SAMs were characterized using ellipsometry, contact angle goniometry, polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS), and X-ray photoelectron spectroscopy (XPS). The comparison revealed that the SAMs generated from the thioacetates are not as densely packed and well ordered as the SAMs generated from the thiols. Furthermore, studies of the kinetics of adsorption found that the thioacetates adsorb more slowly than the corresponding thiols.

show abstract

Section: Introductionmentioning

confidence: 99%

SAMs on Gold Derived from the Direct Adsorption of Alkanethioacetates Are Inferior to Those Derived from the Direct Adsorption of Alkanethiols

et al. 2009

View full text Add to dashboard Cite

show abstract

“…The pursuit of ever smaller tools to treat patients is approaching a pivotal juncture in medical history as advanced nanomedicine — specifically, medical nanorobotics — is expected to serve as a dynamic tool toward addressing most human brain disorders. The goal is to finally empower medical professionals to treat diseases at individual cellular and sub-cellular resolution (Freitas, 1998, 1999b, 2003, 2005a,c, 2007, 2016; Morris, 2001; Astier et al, 2005; Patel et al, 2006; Park et al, 2007; Popov et al, 2007; Mallouk and Sen, 2009; Martel et al, 2009; Kostarelos, 2010; Mavroides and Ferreira, 2011; Boehm, 2013).…”

Section: Introductionmentioning

confidence: 99%

Human Brain/Cloud Interface

Martins

Angelica²,

Chakravarthy

et al. 2019

Front. Neurosci.

View full text Add to dashboard Cite

The Internet comprises a decentralized global system that serves humanity’s collective effort to generate, process, and store data, most of which is handled by the rapidly expanding cloud. A stable, secure, real-time system may allow for interfacing the cloud with the human brain. One promising strategy for enabling such a system, denoted here as a “human brain/cloud interface” (“B/CI”), would be based on technologies referred to here as “neuralnanorobotics.” Future neuralnanorobotics technologies are anticipated to facilitate accurate diagnoses and eventual cures for the ∼400 conditions that affect the human brain. Neuralnanorobotics may also enable a B/CI with controlled connectivity between neural activity and external data storage and processing, via the direct monitoring of the brain’s ∼86 × 10 9 neurons and ∼2 × 10 14 synapses. Subsequent to navigating the human vasculature, three species of neuralnanorobots (endoneurobots, gliabots, and synaptobots) could traverse the blood–brain barrier (BBB), enter the brain parenchyma, ingress into individual human brain cells, and autoposition themselves at the axon initial segments of neurons (endoneurobots), within glial cells (gliabots), and in intimate proximity to synapses (synaptobots). They would then wirelessly transmit up to ∼6 × 10 16 bits per second of synaptically processed and encoded human–brain electrical information via auxiliary nanorobotic fiber optics (30 cm 3 ) with the capacity to handle up to 10 18 bits/sec and provide rapid data transfer to a cloud based supercomputer for real-time brain-state monitoring and data extraction. A neuralnanorobotically enabled human B/CI might serve as a personalized conduit, allowing persons to obtain direct, instantaneous access to virtually any facet of cumulative human knowledge. Other anticipated applications include myriad opportunities to improve education, intelligence, entertainment, traveling, and other interactive experiences. A specialized application might be the capacity to engage in fully immersive experiential/sensory experiences, including what is referred to here as “transparent shadowing” (TS). Through TS, individuals might experience episodic segments of the lives of other willing participants (locally or remote) to, hopefully, encourage and inspire improved understanding and tolerance among all members of the human family.

show abstract

“…Nanomaterials, which consist of particles and other types of matter with at least one dimension in the range of 1 to 100 nm, can be found in numerous everyday items including sunscreens, stain-free clothing, makeup, stained glass, and medicines. ,, The nanotechnology revolution has occurred due to the distinctive physical properties of these materials caused by their small size and high surface-to-volume ratio. Examples include the antibacterial properties of nanosilver or the special magnetic properties (superparamagnetism) of iron oxide magnetic nanoparticles (MNPs). ,− There is also a significant body of research where MNPs have been explored as components of biosensors, as contrast agents, and as carriers for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Microorganisms: Using Chemically Functionalized Magnetic Nanoparticles To Observe and Control Paramecia

Tarkington

Bryan

Kolhatkar³

et al. 2016

J. Chem. Educ.

View full text Add to dashboard Cite

With the growing use of nanotechnology in everyday life, there is a developing need to study the fate and potential impact of nanomaterials in the environment. This multiday laboratory experiment introduces students to magnetic nanoparticles (MNPs) and to the uptake of both uncoated and coated MNPs by microorganisms. To highlight the possible uses and potential consequences of the uptake of MNPs, a procedure was developed to “feed” small magnetic particles to paramecia, a process that can be observed using an optical microscope. During extensive laboratory analysis, uptake of the MNPs by these microorganisms was noted with all three species of paramecia examined: Paramecium aurelia, Paramecium bursaria, and Paramecium caudatum. The paramecia clearly ingested the iron oxide MNPs, but the amount of magnetic material per microorganism varied. In some cases, we were able to manipulate the “magnetized” P. aurelia and P. bursaria using a magnetic field. Uptake of uncoated MNPs led to microorganism death within the initial 12–18 h observation window. However, paramecia that ingested MNPs coated with the polymer poly(vinylpyrrolidone) (PVP) were still alive 1 week after ingestion. Included in this report are the procedures for the synthesis of the iron oxide (Fe3O4) MNPs and their functionalization with PVP, along with an analysis of the chemistry that occurs when uncoated MNPs are present within a cellular environment. Designed for high school students, this engaging experiment integrates chemistry, biology, and physics into the observations of a traditional science laboratory activity, providing a hands-on learning experience.

show abstract

Rise of The Nanomachine: The Evolution of A Revolution in Medicine

Cited by 15 publications

References 122 publications

SAMs on Gold Derived from the Direct Adsorption of Alkanethioacetates Are Inferior to Those Derived from the Direct Adsorption of Alkanethiols

SAMs on Gold Derived from the Direct Adsorption of Alkanethioacetates Are Inferior to Those Derived from the Direct Adsorption of Alkanethiols

Human Brain/Cloud Interface

Magnetic Microorganisms: Using Chemically Functionalized Magnetic Nanoparticles To Observe and Control Paramecia

Contact Info

Product

Resources

About