Rise of the guardians: Gut microbial maneuvers in bacterial infections

Gupta, U; Dey, Priyankar

doi:10.1016/j.lfs.2023.121993

Cited by 10 publications

(1 citation statement)

References 144 publications

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“…The intestinal tract hosts many species of commensal bacteria, which are constantly stimulated by foreign dietary and environmental antigens and maintain a dynamic equilibrium while contributing to the body's normal physiological functions (Airola et al, 2023). Under normal physiological conditions, the intestinal microbiota plays a key role in maintaining the normal structure of the gut, promoting the integrity of the intestinal barrier, and modulating the mucosal immune response by maintaining intercellular connections and promoting epithelial repair (Gupta and Dey, 2023;Iancu et al, 2023). A study evaluates the correlation of changes in gut permeability, bacterial transit, and gut microbiome with AIH progression in patients with AIH.…”

Section: Gut Microbialmentioning

confidence: 99%

The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review

Sun,

Zhu,

Zhu

et al. 2024

Front. Cell. Infect. Microbiol.

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Autoimmune hepatitis (AIH) is a chronic inflammatory disease of the liver that is mediated by autoimmunity and has complex pathogenesis. Its prevalence has increased globally. Since the liver is the first organ to be exposed to harmful substances, such as gut-derived intestinal microbiota and its metabolites, gut health is closely related to liver health, and the “liver-gut axis” allows abnormalities in the gut microbiota to influence the development of liver-related diseases such as AIH. Changes in the composition of the intestinal microbiota and its resultant disruption of the intestinal barrier and microbial transport are involved in multiple ways in the disruption of immune homeostasis and inflammation, thereby influencing the development of AIH. In terms of the mechanisms involved in immune, the gut microbiota or its metabolites, which is decreased in secondary bile acids, short-chain fatty acids (SCFAs), and polyamines, and increased in lipopolysaccharide (LPS), branched-chain amino acids (BCAA), tryptophan metabolite, amino acid, and bile acid, can disrupt immune homeostasis by activating various immune cells and immune-related signaling pathways, resulting in aberrant activation of the immune system. Clarifying this mechanism has significant clinical implications for the treatment of AIH with drugs that target intestinal microbiota and related signaling pathways. Therefore, this narrative review summarizes the progress in exploring the involvement of gut microbiota in the pathogenesis of AIH, with the aim of helping to improve the precise targeting of therapeutic treatments against AIH for the benefit of clinical AIH treatment.

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Section: Gut Microbialmentioning

confidence: 99%

The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review

Sun,

Zhu,

Zhu

et al. 2024

Front. Cell. Infect. Microbiol.

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Innovative Self Nano‐Emulsifying Drug Delivery Systems for Peptic Ulcer Therapy: A Review

Mujtaba,

Arshad,

Aman

et al. 2024

Part & Part Syst Charact

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Peptic ulcer disease (PUD) adversely affects ≈4 million individuals globally and remains pervasive among 5–10% of the general population. Mucosal lesions prompted by the ulceration lead to the penetration through mucosal layers, ultimately resulting in cavity formation and inflammation. Conventional therapeutic modalities for peptic ulcers have shown unfavorable effects, relapses, and numerous drug interactions. The genesis of gastric ulcers is catalyzed via an imbalanced interplay between environmental lesions, defensive mechanisms, and the restoration of gastric mucosa. Lipid based nanotechnology involved in self‐nanoemulsifying drug delivery system (SNEDDS) is being tremendously involved in opening avenues in innovative pharmaceutical delivery systems in terms of improving solubility and regenerative healing against peptic ulcers. Biological macromolecules can be incorporated into SNEDDS to embellish the drug delivery system on an advanced level. Herein, in this review, the potential of SNEDDS as a viable carrier for administering biomacromolecules for regenerative healing in ulcers is discussed in detail.

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Advances in probiotics research: mechanisms of action, health benefits, and limitations in applications

Prajapati,

Bisani,

Prajapati

et al. 2023

Syst Microbiol and Biomanuf

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Rise of the guardians: Gut microbial maneuvers in bacterial infections

Cited by 10 publications

References 144 publications

The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review

The significance of gut microbiota in the etiology of autoimmune hepatitis: a narrative review

Innovative Self Nano‐Emulsifying Drug Delivery Systems for Peptic Ulcer Therapy: A Review

Advances in probiotics research: mechanisms of action, health benefits, and limitations in applications

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