Rise in ciprofloxacin resistance in Escherichia coli from urinary tract infections from 1999–2004

Barišić, Zvonimir; Borzić, Elmica; Kraljević, Katarina Šiško; Carev, Mladen; Zoranić, Vinko; Kaliterna, Vanja

doi:10.1016/j.ijantimicag.2005.04.001

Cited by 8 publications

(4 citation statements)

References 8 publications

(11 reference statements)

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“…However, the excessive and uncontrolled use of fluoroquinolones in clinical and veterinary medicine led to the increasing resistance of bacteria, which reduces the effectiveness of these drugs for future use ( 3 ). Research in Split-Dalmatia County, showed that the rate of resistance in the five year period to ciprofloxacin was increased from 2.48% in 1999 to 7.28% in 2004 ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance of Escherichia Coli Strains Isolated from Urine at Outpatient Population: a Single Laboratory Experience

Vranić

Uzunovic

2016

Mater Sociomed

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Objectives:The aim of this study was to examine antimicrobial resistance of Escherichia coli strains isolated from urine in outpatient population.Material and methods:We performed a retrospective study for tree months period, between January 1st and March 31st, 2015, at the Department of Microbiology and Parasitology, Faculty of Medicine, University of Sarajevo. We determined the E. coli antimicrobial resistance in 556 first urine samples from outpatient population of Hrasno community in Sarajevo, Bosnia and Herzegovina. E. coli is the most frequent agent causing urinary tract infections in outpatients as well. The standard methods of descriptive statistics were performed for data analysis.Results:We observed the highest antimicrobial resistance of E. coli for ampicillin (82,79%), followed by trimethoprim-sulfamethoxazole (40,86%), nalidixic acid (19,35%), cephazolin (7,52%), nitrofurantoin (5,37%), gentamicin (2,15%) and ciprofloxacin (4,30%).Conclusions:The results of study showed that E. coli has the highest resistance to ampicillin and trimethoprim-sulfamethoxazole in outpatient population of Hrasno community.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance of Escherichia Coli Strains Isolated from Urine at Outpatient Population: a Single Laboratory Experience

Vranić

Uzunovic

2016

Mater Sociomed

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“…Because of their medicinal application, these two acids have attracted the attention of numerous dieteticians. Human health is directly influenced by the food properties, inferring not only the nutritive quality of meat but also aquaculture practice consequences such as levels of stress in animals, feeding regimes, antimicrobial administration and choices of medication (Barisic, Borzic, Kraljevic, Carev, Zoranic & Kaliterna 2005). It is important to note that tuna in this study were not fed antibiotics and the stress levels in its management were reduced to minimum.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid and proximate composition of bluefin tuna (Thunnus thynnus) muscle with regard to plasma lipids

Popović

Kozačinski

Strunjak‐Perović

et al. 2011

Aquaculture Research

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The composition of tail muscle fatty acids from wild and cultured bluefin tuna reared on a diet based on herring and sardine, along with the plasma lipid profile of the farmed individuals, was determined. The total lipid content of farmed bluefin in this study was 0.922 g/100 g or 3.49 g of saturated fatty acids (SAFA), 4.48 g of monounsaturated fatty acids (MUFA), 2.58 g polyunsaturated fatty acids (PUFA) n‐3 and 0.37 g of PUFA n‐6 fatty acids; for wild specimens, it was 0.920 g/100 g, or 2.85 g of SAFA, 4.82 g of MUFA, 2.78 g PUFA n‐3 and 0.27 g of PUFA n‐6 fatty acids. The major fatty acids in this study were 16:0; 16:1, n‐7; 18:1, n‐9 and DHA 22:6, n‐3 acids. The sum of these major components accounted for more than 57% and 80% of the total fatty acids in all the samples of farmed and wild tuna respectively. No significant differences in the proximate composition were demonstrated between farmed and wild samples, except for the energy value, in favour of the farmed tuna. Statistically, glucose tends to increase together with cholesterol (CHOL) and plasma triglyceride, as for these pairs, it showed positive correlation coefficients and P>0.05. Some measured tuna metabolites demonstrated strong mutual correlations, especially GLU, CHOL and TRIG, which are crucial factors in the lipid profile of animals.

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“…In a study performed over 5 years in Croatia on changes in susceptibility of E. coli from UTI, Moeal et al have shown a statistically significant change in antimicrobial resistance over that period only for ciprofloxacin [20]. This has been hypothesized to be related to the inappropriate use of quinolones for humans as well as in veterinary medicine [21].…”

Section: Discussionmentioning

confidence: 99%

In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations

et al. 2010

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BackgroundFluoroquinolones are potent antimicrobial agents used for the treatment of a wide variety of community- and nosocomial- infections. However, resistance to fluoroquinolones in Enterobacteriaceae is increasingly reported. Studies assessing the ability of fluoroquinolones to select for resistance have often used antimicrobial concentrations quite different from those actually acquired at the site of infection. The present study compared the ability to select for resistance of levofloxacin, ciprofloxacin and prulifloxacin at concentrations observed in vivo in twenty strains of Escherichia coli and Klebsiella spp. isolated from patients with respiratory and urinary infections. The frequencies of spontaneous single-step mutations at plasma peak and trough antibiotic concentrations were calculated. Multi-step selection of resistance was evaluated by performing 10 serial cultures on agar plates containing a linear gradient from trough to peak antimicrobial concentrations, followed by 10 subcultures on antibiotic-free agar. E. coli resistant strains selected after multi-step selection were characterized for DNA mutations by sequencing gyrA, gyrB, parC and parE genes.ResultsFrequencies of mutations for levofloxacin and ciprofloxacin were less than 10-11 at peak concentration, while for prulifloxacin they ranged from <10-11 to 10-5. The lowest number of resistant mutants after multistep selection was selected by levofloxacin followed by ciprofloxacin and prulifloxacin. Both ciprofloxacin- and prulifloxacin-resistant mutants presented mutations in gyrA and parC, while levofloxacin resistance was found associated only to mutations in gyrA.ConclusionsAmong the tested fluoroquinolones, levofloxacin was the most capable of limiting the occurrence of resistance.

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Rise in ciprofloxacin resistance in Escherichia coli from urinary tract infections from 1999–2004

Cited by 8 publications

References 8 publications

Antimicrobial Resistance of Escherichia Coli Strains Isolated from Urine at Outpatient Population: a Single Laboratory Experience

Antimicrobial Resistance of Escherichia Coli Strains Isolated from Urine at Outpatient Population: a Single Laboratory Experience

Fatty acid and proximate composition of bluefin tuna (Thunnus thynnus) muscle with regard to plasma lipids

In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations

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