Rippled-Pattern Sebaceoma: A Report of a Lesion on the Back With a Review of the Literature

Abstract

A 68-year-old Japanese man presented with a nodule that had been present for 5 to 6 years on the right side of the back. Physical examination revealed a dome-shaped, 12 x 13-mm, dark red nodule. It was excised with a 2 to 3-mm margin. The patient remained free of disease during 77 months of follow-up. Microscopic examination revealed a bulb-like tumor in the dermis, contiguous with the overlying epidermis. It was composed of small, monomorphous, cigar-shaped basaloid cells in linear, parallel rows, resembling the palisading of nuclei of Verocay bodies, and presenting a rippled-pattern. There were scattered cells showing sebaceous differentiation with vacuolated cytoplasm and scalloped nuclei. There were tiny, duct-like spaces. The tumor revealed characteristics of rippled-pattern sebaceoma. The present case is the first reported rippled-pattern sebaceous neoplasm on the back. Many spindle cell tumors, such as basal cell carcinoma, pleomorphic adenoma, dermatofibrosarcoma protuberans, myofibroblastoma, and leiomyoblastoma, in addition to trichoblastoma and sebaceoma, can have a rippled-pattern.

Ripple/Carcinoid Pattern Sebaceoma With Apocrine Differentiation

“…In addition, no cases of sebaceomas with a ripple/carcinoid pattern and apocrine differentiation have previously been reported to be associated with Muir-Torre Syndrome. [1][2][3][4][5][6][7][8][9][10][11][12] …”

“…[1][2][3][4][5][6] In addition, several reports on the association of apocrine differentiation within the lesions of sebaceoma including low-grade sebaceous carcinoma have been recently appeared. [7][8][9] We herein report a case of carcinoid (a partial ripple and labyrinthine) pattern sebaceoma with apocrine differentiation.…”

Central Nuclear Palisading in Nodular Basal Cell Carcinoma: Morphological and Immunohisto­chemical Concerns

“…Verocay-like bodies are also found in other epithelial neoplasms, such as rippled-pattern trichoblastoma (7) and sebaceoma (8); however, the absence of peripheral stromal structures, such as papillary mesenchymal bodies and fibrocellular stroma, makes it difficult to distinguish these neoplasms from BCC with Verocay bodies without additional studies: CK-20 immunoreactive cells and scattered sebaceous cells are useful findings to distinguish trichoblastoma and sebaceoma, respectively, from BCC.…”

Rippled‐pattern trichoblastoma with apocrine differentiation arising in a nevus sebaceus: report of a case and review of the literature

“…Rippled‐pattern TB was first described by Hashimoto et al 14 as rippled‐pattern trichomatricoma and since that time an additional seven cases have been described (including the present report) (Table 1). In addition, a ripple pattern has also been described in sebaceoma 29,30 . Unlike rippled‐pattern TB with sebaceous differentiation, 17 the cases of rippled‐pattern sebaceoma lack papillary mesenchymal bodies, a palisading peripheral border of the basaloid tumor aggregates, and the surrounding fibrocellular stroma that characterizes TB 29,30 .…”