RIPK4 promoted the tumorigenicity of nasopharyngeal carcinoma cells

Gong, Yongqian; Luo, Xinggu; Yang, Jing; Jiang, Qingshan; Liu, Zhifeng

doi:10.1016/j.biopha.2018.08.147

Cited by 26 publications

(25 citation statements)

References 18 publications

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“…expression is upregulated in nasopharyngeal, pancreatic, bladder urothelial and cervical squamous cell carcinoma, and is associated with a poor outcome [30][31][32][33]. Increased SCNN1A contributed to unfavorite prognosis in pulmonary adenocarcinoma and ovarian cancer [34][35].…”

Section: Discussionmentioning

confidence: 99%

Identification of MEG8-miR378d-SOBP Axis as a Novel Regulatory Network and Associated With Immune Infiltrates in Ovarian Carcinoma by Integrated Bioinformatics Analysis

Lei

Wang

et al. 2020

Preprint

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BackgroundTo investigate the potential molecular mechanism of ovarian cancer (OC) evolution and immunological correlation using the integrated bioinformatics analysis.MethodsData from the Gene Expression Omnibus (GEO) was used to gain differentially expressed genes (DEGs). Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were completed by utilizing the Database for Annotation, Visualization, and Integrated Discovery (DAVID). After multiple validation via The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis 2 (GEPIA 2), the Human Protein Atlas (HPA) and Kaplan-Meier (KM) plotter, immune logical relationships of the key gene SOBP were evaluated based on Tumor Immune Estimation Resource (TIMER), and Gene Set Enrichment Analysis (GSEA) software. Finally, the lncRNAs-miRNAs-mRNAs sub-network was predicted by starBase, Targetscan, miRBD, and LncBase, individually. Correlation of expression and prognosis for mRNAs, miRNAs and lncRNAs were confirmed by TCGA, GEPIA 2, starBase, and KM.ResultsA total of 192 shared DEGs were discovered from the four data sets, including 125 upregulated and 67 downregulated genes. Functional enrichment analysis presented that they were mainly enriched in cartilage development, pathway in PI3K-Akt signaling pathway. Lower expression of SOBP was the independent prognostic factor for inferior prognosis in OC patients. Intriguingly, downregulated SOBP enhanced the infiltration levels of B cells, CD8+ T cells, Macrophage, Neutrophil and Dendritic cells. GSEA also disclosed low SOBP showed significantly association with the activation of various immune-related pathways. Finally, we firstly reported that MEG8-miR378d-SOBP axis was linked to development and prognosis of ovarian cancer through regulating cytokines pathway.Conclusions Our study establishes a novel MEG8-miR378d-SOBP axis in the development and prognosis of OC, and the triple sub-network probably affects the progression of ovarian tumor by regulating cytokines pathway.

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Section: Discussionmentioning

confidence: 99%

Identification of MEG8-miR378d-SOBP Axis as a Novel Regulatory Network and Associated With Immune Infiltrates in Ovarian Carcinoma by Integrated Bioinformatics Analysis

Lei

Wang

et al. 2020

Preprint

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“…Though interacting with the adaptor protein DVL2, RIPK4 could stimulate Wnt Signaling pathway with the co-receptor LRP6, which suggests that RIPK4 overexpression may contribute to the growth of OC [18]. Gong et al (2018) revealed that the expression of RIPK4 was up-regulated in nasopharyngeal carcinoma (NPC) tissues and it could promote the growth and anchorage-independent growth of NPC cells, which demonstrated the oncogenic roles of RIPK4 in NPC and suggested that RIPK4 might be a therapeutic target [19]. High expression of RIPK4 was also observed in bladder urothelial carcinoma tissues and was an independent predictor for poor overall survival [20].…”

Section: Discussionmentioning

confidence: 99%

Survival-associated transcriptome analysis in ovarian cancer

Xu¹,

Zhou²,

Wang³

et al. 2020

EJGO

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Purpose of investigation: Ovarian Cancer (OC) is one of the most lethal gynecologic cancers worldwide. Despite the standard treatment, including radical resection, systemic chemotherapy, and targeted drugs for patients, survival rates remain low. This study provides new ideas for the diagnosis and treatment of Ovarian Cancer. Material and Methods: We performed Kaplan-Meier analysis on the transcriptome of Ovarian Cancer based on RNA-Seq data from The Cancer Genome Atlas (TCGA). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) enrichment were used for pathway and functional enrichment. Protein-protein interaction (PPI) network was constructed and visualized by SRING and Cytoscape. Results: A total of 1693 genes associated with survival were identified. The Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology enrichment analysis revealed that these selected genes were differently enriched in numerous functional pathways. The top ten hub genes (RIPK4, HSPA8, FOS, STAT1, CD40LG, FGF2, RAC1, CXCR4, PRPF19, and CXCL10) were identified in our PPI network. Three highly connected cluster modules were differently enriched in several functional pathways. Conclusion: These key biomarkers in Ovarian Cancer may have diagnostic and therapeutic value in the future.

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“…Moreover, it has been shown that NF-κB signaling is, in part, regulated by RIPK4 [138] and that RIPK4 is involved in several oncogenic pathways, including RAF/MEK/ERK signaling and Wnt/beta-catenin signaling [139,140,141]. Multiple studies demonstrated that either up- [139,142] or down-regulation [143,144] of RIPK4 activity is associated with tumor progression and an unfavorable oncological outcome in several cancers.…”

Section: Hydroxylation Of Non-hif Targets Mediated By Factor-inhibmentioning

confidence: 99%

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

Strowitzki

Cummins

Taylor

2019

Cells

163

146

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All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is mediated through activation of the hypoxia-inducible factor (HIF) pathway. At physiological oxygen levels (normoxia), HIF-prolyl hydroxylases (PHDs) hydroxylate proline residues on HIF-α subunits leading to their destabilization by promoting ubiquitination by the von-Hippel Lindau (VHL) ubiquitin ligase and subsequent proteasomal degradation. HIF-α transactivation is also repressed in an O2-dependent way due to asparaginyl hydroxylation by the factor-inhibiting HIF (FIH). In hypoxia, the O2-dependent hydroxylation of HIF-α subunits by PHDs and FIH is reduced, resulting in HIF-α accumulation, dimerization with HIF-β and migration into the nucleus to induce an adaptive transcriptional response. Although HIFs are the canonical substrates for PHD- and FIH-mediated protein hydroxylation, increasing evidence indicates that these hydroxylases may also have alternative targets. In addition to PHD-conferred alterations in protein stability, there is now evidence that hydroxylation can affect protein activity and protein/protein interactions for alternative substrates. PHDs can be pharmacologically inhibited by a new class of drugs termed prolyl hydroxylase inhibitors which have recently been approved for the treatment of anemia associated with chronic kidney disease. The identification of alternative targets of HIF hydroxylases is important in order to fully elucidate the pharmacology of hydroxylase inhibitors (PHI). Despite significant technical advances, screening, detection and verification of alternative functional targets for PHDs and FIH remain challenging. In this review, we discuss recently proposed non-HIF targets for PHDs and FIH and provide an overview of the techniques used to identify these.

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RIPK4 promoted the tumorigenicity of nasopharyngeal carcinoma cells

Cited by 26 publications

References 18 publications

Identification of MEG8-miR378d-SOBP Axis as a Novel Regulatory Network and Associated With Immune Infiltrates in Ovarian Carcinoma by Integrated Bioinformatics Analysis

Identification of MEG8-miR378d-SOBP Axis as a Novel Regulatory Network and Associated With Immune Infiltrates in Ovarian Carcinoma by Integrated Bioinformatics Analysis

Survival-associated transcriptome analysis in ovarian cancer

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

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