Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms

Lopes, Iardja Stéfane; Oliveira, Iris Cristina Maia; Capibaribe, Victor Celso Cavalcanti; Valentim, José Tiago; Silva, Daniel Moreira Alves da; Souza, Alana Gomes de; Araújo, Mariana Albuquerque de; Chaves, Raquell de Castro; Gutierrez, Stanley Juan Chaves; Barbosa-Filho, José Maria; Macêdo, Danielle Silveira; Sousa, Francisca Cléa Florenço de

doi:10.1016/j.neuint.2018.07.007

Cited by 31 publications

(20 citation statements)

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“…Decreased TrkB levels may be associated with lower BDNF in these animals and a better simulation by the UCMS model. There are numerous studies demonstrating that hippocampal BDNF decreases after CORT and OB model induction (Gourley, Kiraly, Howell, Olausson, & Taylor, ; Lopes et al, ). Though the common hypothesis of depression predicts decreased BDNF expression in depression‐related brain areas, our results showed increased BDNF protein in CORT and OB mice at week 5.…”

Section: Discussionmentioning

confidence: 99%

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

et al. 2019

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Objective:The present study was designed to explore the long-term differences between three mouse models for depression. Method:In the present study, the unpredictable chronic mild stress (UCMS) model, the glucocorticoid/corticosterone model, and the olfactory bulbectomy model were compared at two, three, and five weeks after model induction. Behavioral testing performed included forced-swimming, tail suspension, open-field and elevated plusmaze tests. In addition, 5-hydroxytryptamine (5-HT) and dopamine levels, and mRNA and protein expressions related to 5-HT synthesis, transport, and signaling were analyzed in the hippocampus of tested animals. Results:Our results revealed that each model demonstrated a specific profile of markers, whereas the stability of them differed over testing time. Conclusions:Each model provided a unique set of advantages that can be considered depending on the context and aims of each study. Among the three models, the UCMS model was mostly stable and appeared to the best model for testing long-term depression-like state. K E Y W O R D S 5-HT, corticosterone, depression model, glucocorticoid, olfactory bulbectomy, UCMS How to cite this article: Zhu H, Tao Y, Wang T, et al. Long-term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression. Brain Behav. 2020;10:e01508. https ://doi.

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Section: Discussionmentioning

confidence: 99%

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

et al. 2019

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“…Evidence suggests that alkamides can readily cross the skin, oral and gut mucosa and that they can traverse the blood brain barrier [5]. In rodent models, the alkamide riparin II has been shown to reduce anxiety [6] and attenuate depression via monoaminergic mechanisms [7]. In a medicinal context, ZA is most likely to be encountered as a component of the traditional Japanese herbal medicine Daikenchuto, which comprises ginger rhizome, ginseng root, rice gluten and Zanthoxylum fruit.…”

Section: Introductionmentioning

confidence: 99%

The Acute and Chronic Cognitive and Cerebral Blood-Flow Effects of Nepalese Pepper (Zanthoxylum armatum DC.) Extract—A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Humans

et al. 2019

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Background: Zanthoxylum armatum DC. (ZA) is a traditional Asian culinary spice and medicinal compound, which is rich in monoterpenes and hydroxy α-sanshool. Mechanistic interactions with the monoamine, cholinergic and cannabinoid neurotransmission systems, as well as transient receptor potential (TRP) and potassium ion channels, may predispose ZA to modulate human brain function. Objectives: To investigate the effects of a single dose and 56-days supplementation with a lipid extract of ZA on cognitive function, mood and cerebral blood-flow (CBF) parameters in the pre-frontal cortex during cognitive task performance. Design: Double-blind, randomized, parallel groups study with N = 82 healthy males and females between the ages of 30 and 55 years. Assessments were undertaken pre-dose and at 1, 3 and 5 h post-dose on the first (Day 1) and last (Day 56) days of supplementation. Results: A single dose of ZA (Day 1) resulted in acute improvements on a ‘Speed of Attention’ factor and the Rapid Visual Information Processing (RVIP) task, in comparison to placebo. However, following ZA participants were less accurate on the name-to-face recall task. After 56 days of ZA consumption (Day 56), speed was enhanced on a global ‘Speed of Performance’ measure, comprising data from all of the timed tasks in the computerized battery. Participants also completed more correct Serial 3s Subtractions at the 3 h assessment and were less mentally fatigued throughout the day than participants consuming placebo. These effects were complemented on both Day 1 and Day 56 by modulation of CBF parameters, as assessed by Near Infrared Spectroscopy (NIRS). The primary finding here was a reduced hemodynamic response during the RVIP task. Conclusion: ZA improves aspects of cognitive performance, in particular the speed of performing tasks, in healthy humans and results in concomitant reductions in hemodynamic responses in the frontal cortex during task performance. The findings suggest an increase in neural efficiency following ZA.

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“…Repeated corticosterone injections have been widely used to establish the mouse model of depression ( Zhao et al, 2008 ). Following the similar protocol as previously described ( Lopes et al, 2018 ; Chaves et al, 2019 ), corticosterone (Sigma-Aldrich, St Louis, MO, United States) was dissolved with dimethylsulfoxide (DMSO, 0.1%; Sigma-Aldrich) and Tween-80 (0.1%; Sigma-Aldrich) in the sterile phosphate-buffered saline (PBS), followed by the 10-min vortexing and 1-h ultra-sonication (Branson Ultrasonics, Danbury, CT, United States) before injection. Corticosterone at a dose of 20 mg/kg body weight was subcutaneously administered daily for 3 weeks.…”

Section: Methodsmentioning

confidence: 99%

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

Wang

Liang

Chen

et al. 2020

Front. Cell. Neurosci.

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Adiponectin, a cytokine secreted by mature adipocytes, proves to be neuroprotective. We have previously reported that running triggers adiponectin up-regulation which subsequently promotes generation of hippocampal neurons and thereby alleviates depression-like behaviors in non-stressed mice. However, under the stressing condition, whether adiponectin could still exert antidepressant-like effects following exercise remained unexplored. In this study, by means of repeated corticosterone injections to mimic stress insult and voluntary wheel running as physical exercise intervention, we examined whether exercise-elicited antidepressive effects might involve adiponectin's regulation on hippocampal neurogenesis and dendritic plasticity in stressed mice. Here we show that repeated injections of corticosterone inhibited hippocampal neurogenesis and impaired dendritic morphology of neurons in the dentate gyrus of both wild-type and adiponectin-knockout mice comparably, which subsequently evoked depression-like behaviors. Voluntary wheel running attenuated corticosterone-suppressed neurogenesis and enhanced dendritic plasticity in the hippocampus, ultimately reducing depressionlike behaviors in wild-type, but not adiponectin-knockout mice. We further demonstrate that such proneurogenic effects were potentially achieved through activation of the AMP-dependent kinase (AMPK) pathway. Our study provides the first evidence that adiponectin signaling is essential for physical exercise-triggered effects on stress-elicited depression by retaining the normal proliferation of neural progenitors and dendritic morphology of neurons in the hippocampal dentate gyrus, which may depend on activation of the AMPK pathway.

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Riparin II ameliorates corticosterone-induced depressive-like behavior in mice: Role of antioxidant and neurotrophic mechanisms

Cited by 31 publications

References 83 publications

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

Long‐term stability and characteristics of behavioral, biochemical, and molecular markers of three different rodent models for depression

The Acute and Chronic Cognitive and Cerebral Blood-Flow Effects of Nepalese Pepper (Zanthoxylum armatum DC.) Extract—A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Humans

Potential Involvement of Adiponectin Signaling in Regulating Physical Exercise-Elicited Hippocampal Neurogenesis and Dendritic Morphology in Stressed Mice

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