Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Abstract

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Loss of PKGIβ/IRAG1 Signaling Causes Anemia-Associated Splenomegaly

“…Hence, cGMP signaling is relevant for different forms of anemia. However, cGMP modulators such as sGC stimulators and PDE5 inhibitors can also induce bleeding by inhibition of platelet function [ 36 , 37 ]. This must be considered in the therapy.…”

Haemoptysis in Pulmonary Arterial Hypertension Associated with Congenital Heart Disease: Insights on Pathophysiology, Diagnosis and Management

“…Recently, another prospective open-label study of riociguat in patients with PAH reported haemoptysis in 2.5% of patients (n = 8). Of the six patients with serious hemoptysis, three were receiving concomitant anticoagulants, two were receiving a concomitant prostanoid, and one was receiving concomitant antiplatelet therapy [34]. Therefore, the role of PAH targeted therapies in triggering haemoptysis and the underlying mechanisms have yet to be proved.…”

Chronic thromboembolic pulmonary hypertension after an acute pulmonary embolism: fundamental concepts of diagnosis and review of current treatment options

“…Благоприятный профиль безопасности препарата был продемонстрирован и при длительном наблюдении в условиях реальной клинической практики за пациентами с ХТЭЛГ. По результатам анализа финальных данных регистра EXPERT новых сигналов безопасности риоцигуата выявлено не было [40].…”