Rinitis y asma: una vía respiratoria, una enfermedad

Serrano, Carlos; Valero, Antonio; Picado, César

doi:10.1157/13079841

Cited by 22 publications

(4 citation statements)

References 59 publications

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“…Moreover, the production of inflammatory mediators and cytokines and their subsequent actions at the upper and lower levels of the respiratory tract, confirms the relationship between asthma and CRS [31]. Therefore, they are coexisting in the airway as a single disease [32]. Importantly, our data revealed that CRS was positively associated with current, early and late-onset of asthma.…”

Section: Discussionsupporting

confidence: 83%

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA2LEN study

Ostovar

Fokkens

Pordel

et al. 2019

Clin Transl Allergy

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Background Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA 2 LEN) questionnaire and examine its association with chronic rhinosinusitis, in the province of Bushehr, Southwestern of Iran. Methods In a cross-sectional, population-based study, a total of 5420 invited individuals, aged 15–65, were selected through a multi-stage, stratified, cluster random sampling and from which 5201 completed the GA 2 LEN questionnaire (response rate = 95.9%). The prevalence of asthma, current, and physician-diagnosed asthma were analyzed by using sex and age groups and the association of asthma and chronic rhinosinusitis (CRS) was investigated using a multiple logistic regression model. Results Based on the information from the GA 2 LEN questionnaire, the overall prevalence of asthma in the population under study was 10.0% (95% CI 9.2–10.8). Moreover, the prevalence of current asthma was 8.9% (95% CI 8.1–9.7). Further, the prevalence of current early, late-onset and physician-diagnosed asthma within the asthma group was 51.1% (95% CI 46.5–55.7), 48.9% (95% CI 44.3–53.5) and 3.9% (95% CI 2.1–2.5), respectively. Additionally, CRS was more frequent among the participants with asthma [(57.3%, OR = 2.3; 95% CI 2.1–2.5)], and there was a significant association between CRS and current, early and late-onset of asthma (P < 0.001; OR = 4.4, 3.2 and 6, respectively). Conclusion This large population study conducted in the southwestern part of Iran suggests that the prevalence of asthma is high. Moreover, the result of this study showed a strong association of asthma with CRS; also after adjusting for sex, age, educational level, and smoking.

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Section: Discussionsupporting

confidence: 83%

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA2LEN study

Ostovar

Fokkens

Pordel

et al. 2019

Clin Transl Allergy

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show abstract

“…This model has been extensively investigated concerning the relationship between rhinitis and asthma . Patients with rhinosinusitis are more likely to develop asthma, and rhinitis is almost ubiquitous in patients with asthma.…”

Section: Introduction: the “One Airway One Disease” Holistic Modelmentioning

confidence: 99%

“…Many patients with rhinitis of any type, with no asthma, present subclinical (asymptomatic) dysfunction of their lower airways such as bronchial hyperreactivity (BHR), inflammation and impairment of lung function, which could be associated with an increased risk for the development of clinical asthma . The objectives of this review are to describe the subclinical lower airway abnormalities in patients with rhinitis but without asthma, its probable progression and the possible effects of therapeutic intervention on its natural evolution.…”

Section: Introduction: the “One Airway One Disease” Holistic Modelmentioning

confidence: 99%

Subclinical lower airways correlates of chronic allergic and non‐allergic rhinitis

Saranz

Lozano

et al. 2017

Clin Experimental Allergy

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The upper and lower airways behave as a physiological and pathophysiological unit. Subclinical lower airways abnormalities have been described in patients with rhinitis without asthma. These are expressed as bronchial hyperreactivity, abnormalities in lung function and bronchial inflammation, likely as a result of the same phenomenon with systemic inflammatory impact that reaches both the nose and the lungs, which for unknown reasons does not always have a full clinical expression. Patients with rhinitis are at increased risk of developing asthma; therefore, most authors suggest a careful clinical evaluation and monitoring of these patients, especially if symptoms related to inflammation in the lower airways are observed. Although current treatments, such as H1-antihistamines, intranasal steroids and allergen immunotherapy, are quite effective for the management of rhinitis, it is difficult to prove their capacity to prevent asthma among subjects with rhinitis. Evidence showing that the treatment of rhinitis has a favourable impact on indicators of bronchial hyperreactivity and inflammation among subjects that have no symptoms of asthma is more frequently described. In this review, we address the frequency and characteristics of lower airway abnormalities in subjects with rhinitis, both in paediatric and adult populations, their likely predictive value for the development of asthma and the possibilities for therapeutic intervention that could modify the risk of subjects with rhinitis towards presenting asthma.

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“…71Por otro lado se ha descrito que el uso de un tratamiento combinado (antihistamínico y antileucotrieno) en pacientes con asma y rinitis alérgica parece más eficaz que su uso individual. (72) Un estudio de revisión de literatura farmacoeconómica, que valorara el uso de los antihistamínicos en el tratamiento de RA en los EEUU; evidenció preliminarmente que los nuevos antihistamínicos de segunda generación ofrecen ventajas clínicas, farmacodinámicas y farmacocinéticas, de modo que pueden interpretarse como una excelente relación costo-efectividad en el tratamiento de la RA. 73Dentro del estudio es importante señalar que se utilizaron en la distintas unidades antihistamínicos H1 tanto de primera como de segunda generación, siendo el medicamento más utilizado de esta familia la fexofenadina (más del 41% de los casos)siendo los pacientes tanto adultos como pediátricos de ORL a los que más se les prescribió este medicamento.…”

Section: V2b Asmaunclassified

Análisis del tratamiento médico y calidad de vida en pacientes con rinitis y asma del hospital Escalante Pradilla, Pérez Zeledón, Costa Rica. Período 2012-2013

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Rinitis y asma: una vía respiratoria, una enfermedad

Cited by 22 publications

References 59 publications

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA2LEN study

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA2LEN study

Subclinical lower airways correlates of chronic allergic and non‐allergic rhinitis

Análisis del tratamiento médico y calidad de vida en pacientes con rinitis y asma del hospital Escalante Pradilla, Pérez Zeledón, Costa Rica. Período 2012-2013

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