Rings, chains and helices: new antimicrobial silver coordination compounds with (iso-)nicotinic acid derivatives

Chevrier, Inès; Sague, Jorge; Brunetto, Priscilla S.; Khanna, Nina; Rajacic, Zarko; Fromm, Katharina M.

doi:10.1039/c2dt31259j

Cited by 42 publications

(51 citation statements)

References 119 publications

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“…The agar inhibition assay was performed as previously published (28). Briefly, MHA was inoculated with S. epidermidis 1457 or S. aureus SA113 (1 ϫ 10 4 , 1 ϫ 10 6 , and 1 ϫ 10 7 CFU/ml).…”

Section: Methodsmentioning

confidence: 99%

Preventing Implant-Associated Infections by Silver Coating

Kuehl

Brunetto

Woischnig

et al. 2016

Antimicrob Agents Chemother

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d Implant-associated infections (IAIs) are a dreaded complication mainly caused by biofilm-forming staphylococci. Implant surfaces preventing microbial colonization would be desirable. We examined the preventive effect of a silver-coated titanium-aluminum-niobium (TiAlNb) alloy. The surface elicited a strong, inoculum-dependent activity against Staphylococcus epidermidis and Staphylococcus aureus in an agar inhibition assay. Gamma sterilization and alcohol disinfection did not alter the effect. In a tissue cage mouse model, silver coating of TiAlNb cages prevented perioperative infections in an inoculum-dependent manner and led to a 100% prevention rate after challenge with 2 ؋ 10 6 CFU of S. epidermidis per cage. In S. aureus infections, silver coating had only limited effect. Similarly, daptomycin or vancomycin prophylaxis alone did not prevent S. aureus infections. However, silver coating combined with daptomycin or vancomycin prophylaxis thwarted methicillin-resistant S. aureus infections at a prevention rate of 100% or 33%, respectively. Moreover, silver release from the surface was independent of infection and occurred rapidly after implantation. On day 2, a peak of 82 g Ag/ml was reached in the cage fluid, corresponding to almost 6؋ the MIC of the staphylococci. Cytotoxicity toward leukocytes in the cage was low and temporary. Surrounding tissue did not reveal histological signs of silver toxicity. In vitro, no emergence of silver resistance was observed in several clinical strains of staphylococci upon serial subinhibitory silver exposures. In conclusion, our data demonstrate that silver-coated TiAlNb is potent for prevention of IAIs and thus can be considered for clinical application.

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Section: Methodsmentioning

confidence: 99%

Preventing Implant-Associated Infections by Silver Coating

Kuehl

Brunetto

Woischnig

et al. 2016

Antimicrob Agents Chemother

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“…The longer ligands become more flexible and water soluble [25] and feature not only chain compounds [11], but also metallacyclic species. The effect of the ligand length on the coordination modes towards silver ions has also been studied [14,26].…”

Section: Applications and Outlooksmentioning

confidence: 99%

“…We started to investigate silver coordination polymers using the neutral ligand ethanediyl bis(isonicotinate) Li1 (Scheme 1) [9,10] and its derivatives, which can be modified by simple elongation of the middle spacer, using diethylene glycol [11], triethylene glycol [12,13] and tetraethylene glycol [13,14] as starting materials for the synthesis of the ligands. In this manuscript however, we will focus on the shortest variant of the ligand, Li1.…”

Section: Introductionmentioning

confidence: 99%

Silver coordination polymers with isonicotinic acid derived short polyethylene glycol – Synthesis, structures, anion effect and solution behavior

Fromm

Sague

Robin

2013

Inorganica Chimica Acta

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Silver coordination compounds and one-dimensional polymers have been studied, using a linear, flexible N-donor ligand. The solid state structures are well known and show panoply of different structures including a large number of polymorphism, pseudo-polymorphism and isomers. We have studied these structures under the influence of anions, solvents and crystallization conditions, studying also some solution effects. We here present an overview with highlights of some case studies of the synthesis, structures, anion and solvent effects as well as solution behavior during formation of silver coordination polymers. Finally, we will give an outlook on the potential applications of these materials.⇑ Corresponding author.

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“…S3 Shorter ligands and the use of a non-coordination anion then lead to metallacycle formation rather than double helical coordination polymers. 22 Thus, the role of the anion is crucial in these cases and may have an opposite effect depending on the length of the ligands used.…”

Section: å ) These Findings Indicate That There Is a P-p-interactionmentioning

confidence: 99%

Effect of increasing ligand length on the structure of silver complexes

Gschwind

Fromm

2012

CrystEngComm

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A new series of ligands in which nicotinic acid was linked to different monomethyloligoethers and their corresponding silver complexes were prepared. The crystal structures of the silver compounds were investigated to determine the effect of increasing flexibility of the ligands on coordination to the metal ion and crystal packing. We observed the formation of one-dimensional coordination polymers for the shortest ligand derived from monoethylene glycol, the formation of stacks for the diethyleneglycol-based ligand with silver triflate, and even a helical structure for the triethylene-glycol-derived ligand complex. The three ligands, ([C 9 H 11

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Rings, chains and helices: new antimicrobial silver coordination compounds with (iso-)nicotinic acid derivatives

Cited by 42 publications

References 119 publications

Preventing Implant-Associated Infections by Silver Coating

Preventing Implant-Associated Infections by Silver Coating

Silver coordination polymers with isonicotinic acid derived short polyethylene glycol – Synthesis, structures, anion effect and solution behavior

Effect of increasing ligand length on the structure of silver complexes

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