Ring-Opening Metathesis Polymerization from Surfaces

Weck, Marcus; Jackiw, Jennifer J.; Rossi, Roberto A.; Weiss, Paul S.; Grubbs, Robert H.

doi:10.1021/ja983297y

Cited by 265 publications

(225 citation statements)

References 13 publications

(13 reference statements)

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“…[32,33] We hypothesized that coatings of this nature would be a prerequisite for protein resistance, based on the findings of Whitesides, Grunze, and others. [6,16,34] Many polymerization mechanisms have been realized in a SIP format, including living cationic and anionic polymerization, [35,36] ring-opening metathesis polymerization, [37,38] condensation polymerization, [39,40] free-radical polymerization, [32,[41][42][43] and atom-transfer radical polymerization (ATRP). [44][45][46][47] We chose ATRP largely because it is simple to perform, affords good control of polymerization kinetics, and is compatible with a range of solvents.…”

Section: à2mentioning

confidence: 99%

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins

2009

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Protein resistant or “non‐fouling” surfaces are of great interest for a variety of biomedical and biotechnology applications. This article briefly reviews the development of protein resistant surfaces, followed by recent research on a new methodology to fabricate non‐fouling surfaces by surface‐initiated polymerization. We show that polymer brushes synthesized by surface‐initiated polymerization that present short oligo(ethylene glycol) side chains are exceptionally resistant to protein adsorption and cell adhesion. The importance of the protein and cell resistance conferred by these polymer brushes is illustrated by their use as substrates for the fabrication of antibody microarrays that exhibit femtomolar limits of detection in complex fluids such as serum and blood with relaxed requirements for intermediate wash steps. This example highlights the important point that the reduction in background noise afforded by protein‐resistant surfaces can greatly simplify the development of ultrasensitive heterogeneous, surface‐based clinical and proteomic assays with increased sensitivity and utility.

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Section: à2mentioning

confidence: 99%

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins

2009

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“…37,38 After exposing the alkanethiolate SAMs to guest molecules either in solution, vapor, or by contact (e.g., with a patterned polymer stamp), single molecules can be selectively inserted at the defect sites. 3,23,26,27,30,31,[39][40][41][42][43][44][45] Due to physical constraints from the surrounding matrix and (optional) designed intermolecular interactions, the inserted molecules are limited in their motion and stabilized in specific conformations. The resulting surface structure, as shown in Figure 1c, consists of isolated molecules protruding from host SAM matrices, enabling measurements of driven molecular switching at the single-molecule level by STM.…”

Section: Self-assembly and Measurementsmentioning

confidence: 99%

“…[41][42][43][49][50][51] Highly conjugated molecules, such as oligo(phenylene ethynylene)s (OPEs), polyporphyrins, polythiophenes, and polyphenylenes, have been targeted for such devices due to their relatively high electrical conductivity. 32,33,35,42,52,53 Isolating single molecules of OPE derivatives within defect sites of n-alkanethiolate SAMs 38,39,51,54 is a convenient way to study single, isolated molecules over long timescales (hours and longer).…”

Section: Single-molecule Switchingmentioning

confidence: 99%

Molecular, Supramolecular, and Macromolecular Motors and Artificial Muscles

Li¹,

Paxton²,

Baughman³

et al. 2009

MRS Bull.

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Recent developments in chemical synthesis, nanoscale assembly, and molecularscale measurements enable the extension of the concept of macroscopic machines to the molecular and supramolecular levels. Molecular machines are capable of performing mechanical movements in response to external stimuli. They offer the potential to couple electrical or other forms of energy to mechanical action at the nano-and molecular scales. Working hierarchically and in concert, they can form actuators referred to as artificial muscles, in analogy to biological systems. We describe the principles behind driven motion and assembly at the molecular scale and recent advances in the field of molecular-level electromechanical machines, molecular motors, and artificial muscles. We discuss the challenges and successes in making these assemblies work cooperatively to function at larger scales.

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“…A patterned elastomeric stamp coated with the molecules to be patterned is brought into contact with a substrate coated with a preexisting monolayer that is not easily displaced; the molecules on the stamp insert into the defects in the preexisting monolayer where the stamp and substrate are in contact. Schematics are not to scale terminal functionalities from the preexisitng SAM are inserted into its defect sites (Weck et al 1999;Mullen et al 2007b;Shuster et al 2008). Subsequently, the terminal groups of the tether molecules are functionalized with small-molecule ligands.…”

Section: Chemically Patterned Surfacesmentioning

confidence: 99%

Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions

et al. 2008

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In this perspective, we explore hybrid approaches to nanometer-scale patterning, where the precision of molecular self-assembly is combined with the sophistication and fidelity of lithography. Two areas--improving existing lithographic techniques through self-assembly and fabricating chemically patterned surfaces--will be discussed in terms of their advantages, limitations, applications, and future outlook. The creation of such chemical patterns enables new capabilities, including the assembly of biospecific surfaces to be recognized by, and to capture analytes from, complex mixtures. Finally, we speculate on the potential impact and upcoming challenges of these hybrid strategies.

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Ring-Opening Metathesis Polymerization from Surfaces

Cited by 265 publications

References 13 publications

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins

In Pursuit of Zero: Polymer Brushes that Resist the Adsorption of Proteins

Molecular, Supramolecular, and Macromolecular Motors and Artificial Muscles

Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions

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