Ring-Closing Metathesis Reactions of Bis(enynes): Selectivity and Surprises

Abstract

A study of the ring-closing metathesis reactions of two bis(enynes) is presented. These substrates, which contain two alkenes and two alkynes, as well as a resident stereocenter, can potentially generate metathesis products resulting from many reaction pathways. In this contribution we present our results on these reactions, show how small changes in reaction conditions can lead to different product ratios, and attempt to provide a rationale for the outcomes.

Ruthenium indenylidene “1st generation” olefin metathesis catalysts containing triisopropyl phosphite

“…Because of the recent interest in “1 st generation” complexes [ 9 , 38 – 40 ], previous findings concerning “2 nd generation” complexes [ 25 – 33 ] and the desire to further reduce catalyst cost, the aim of this contribution is to replace the phosphine ligands in Ind-I with the less expensive triisopropyl phosphite and to study the structural and catalytic properties of these new species.…”