Ring-Calcification of Giant Coronary Artery Aneurysm of an 11-Year-Old Child with History of Kawasaki Disease

Salamat, Mehrdad; Khan, Muhammad

doi:10.1007/s00246-009-9594-z

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Previous studies have found that vasoactive factors, including vascular endothelial growth factors, nitric oxide, and platelet-derived growth factors, etc., may initiate the migration and proliferation of SMCs, as well as control the vascular permeability of KD progression [1-5, 32, 33]. Accumulating clinical data has further indicated that KD patients with large aneurysms may have an increased incidence of coronary artery calcification formation [27][28][29]. Moreover, it has been suggested that coronary artery calcification may be one of the sequelae of severe vasculitis occurring in acute KD patients [27][28][29].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating clinical data has further indicated that KD patients with large aneurysms may have an increased incidence of coronary artery calcification formation [27][28][29]. Moreover, it has been suggested that coronary artery calcification may be one of the sequelae of severe vasculitis occurring in acute KD patients [27][28][29]. The clinical symptoms of vascular calcification in KD patients has already been demonstrated, however its mechanism is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…These pathogenic phenomena have been indicated to resemble those of atherosclerosis development. Moreover, accumulating clinical data has also found that KD patients with large aneurysms may be prone to the formation of coronary artery calcification [27][28][29]. However, the mechanism of vascular calcification within KD progression is still unclear.…”

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confidence: 99%

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Serum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro

et al. 2020

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Background: Kawasaki disease (KD) is one of the major causes of heart disease and vasculitis in children under 5 years old in the world. Clinical evidence has shown that coronary artery calcification may develop in KD patients, however the mechanism has not been elucidated. Previous studies have found that interferon-γ-inducible protein (IP)-10 and interleukin (IL)-17 can be elevated and may play a role in KD development and coronary artery lesion formation. The purpose of this in vitro study was to investigate the possible role of plasma circulating IP-10 and IL-17 of KD patients in vascular calcification development and its underlying mechanism. Result: Human coronary artery smooth muscle cells (HCASMCs) were used in this study. We found that HCASMCs treated with IP-10/IL-17-containing KD serum and co-treated with IP-10/IL-17 recombinant proteins could induce a phenotype that may promote vascular calcification by the bone morphogenetic protein (BMP) 6 autocrine effect. Moreover, the BMP6 autocrine stimulation in IP-10/IL-17 co-treated HCASMCs could upregulate the smad1/5-runx2 signaling activation, thus increasing the expression of bone matrix-related proteins, i.e., osteopontin, osteocalcin, and alkaline phosphatase. Conclusions: The presented in vitro results provided new insights into the comprehension of the pathogenesis of vascular calcification in SMCs in KD progression. Although additional in vivo experimental models should be completed to confirm the in vivo relevance of these in vitro findings, the results related to the autocrine role of BMP6 may provide a new direction for theranostic drug development to treat KD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro

et al. 2020

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“…7–11 We did not have chest radiographs on the subjects in this study, and hence were unable to compare data between chest radiographs and CT. Some of the subjects in this study had dense calcification that would be expected to be apparent on chest radiographs.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Calcium Scoring as a Screening Examination in Patients With a History of Kawasaki Disease

Kahn

Budoff

Daniels

et al. 2017

The American Journal of Cardiology

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Subsets of patients with a remote history of Kawasaki disease (KD) have coronary artery aneurysms with associated risks of late morbidity. In a pilot study we previously showed that computed tomography (CT) coronary artery calcium (CAC) scoring detects late CAC in patients with aneurysms and a remote history of KD. We performed CT calcium volume scoring in 166 subjects (median age 19.5 years) with a remote history of KD (median interval from KD to CT 15.1 years). Coronary arteries were classified as normal (n = 100), transiently dilated (n = 23), persistently dilated (n = 10), remodeled aneurysm (n = 9), or aneurysm (n = 24) based on echocardiography. All subjects with coronary arteries classified as normal, persistently dilated, or remodeled aneurysm had zero CAC. Of the 24 subjects with coronary aneurysms, all but five had CAC (median volume 542 mm3; range 17 mm3 to 8,218 mm3). For subjects imaged nine or more years after their acute KD (n=144), the presence of CAC had a sensitivity of 95% and a specificity of 100% for detecting coronary artery abnormalities (defined as coronary artery aneurysm and/or stenosis). In conclusion, coronary calcification was not observed in subjects with a history of KD who had normal coronary arteries by echocardiography during the acute phase. Coronary calcification, which may be severe, occurs late in patients with coronary aneurysms. Therefore, CAC scanning may be a useful tool to screen patients with a remote history of KD or suspected KD and unknown coronary artery status.

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“…The LMA in children is often found in Kawasaki or Takayasu disease. It may also be associated with other cardiac defects such as postponement of the main arteries, or tetralogy of Fallot [7, 8]. A definitive diagnosis can rarely be made.…”

Section: Introductionmentioning

confidence: 99%

Left main aneurysm and what’s next?

Ściborski¹,

Kaaz

Drozdz³

et al. 2014

pwki

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Ring-Calcification of Giant Coronary Artery Aneurysm of an 11-Year-Old Child with History of Kawasaki Disease

Abstract: We present radiographic images of ring-calcification of a giant aneurysm of the left main coronary artery in a child, 7 years after the initial diagnosis of Kawasaki disease, as well as acute medical management and surgical bypass of the obstructed left anterior descending coronary artery.

Cited by 3 publications

References 5 publications

Serum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro

Serum IP-10 and IL-17 from Kawasaki disease patients induce calcification-related genes and proteins in human coronary artery smooth muscle cells in vitro

Usefulness of Calcium Scoring as a Screening Examination in Patients With a History of Kawasaki Disease

Left main aneurysm and what’s next?

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