Rim-differentiated pillar[5]arenes

Copillar[5]arene Chemistry: Synthesis and Applications

“…One strategy to achieve regioselective bisfunctionalization of pillar [5]arenes is to differentiate the two rims of these macromolecules, as shown in A (Figure 2). [20][21][22] A second strategy is to generate copillars B that display two different groups on the pillararene structure, in which at least one of the hydroquinone units bears distinct functional groups in comparison to the others. 23 The synthesis of rim-differentiated pillar [5]arenes of type A usually results in low yields and separation difficulties.…”

“…One strategy to achieve regioselective functionalization of pillar [5]arenes is the differentiation of the two rims of these macromolecules (A) (Figure 2). [20][21][22] Another approach to display two distinct groups on a pillararene structure is to generate copillars B. In copillars, at least one of the hydroquinone units bears a different functional groups com-pared to the others.…”

The Detection of Food Additives Using a Fluorescence Indicator Based on 6– p–Toluidinylnaphthalence-2-sulfonate and Cationic Pillar[6]arene

“…With the advancement of host-guest chemistry, macrocyclic host-based FID assays have garnered widespread attention for their potential application in the field of analytical testing, and several significant research results have been generated in recent years ( Dsouza et al, 2011 ; Ghale et al, 2014 ; Cao et al, 2019 ; Jiang et al, 2020 ). Macrocyclic hosts, primarily cyclodextrins ( Crini, et al, 2014 ; Pal, et al, 2015 ), calixarenes ( Koh, et al, 1996 ; Hennig, et al, 2007 ; Guo, et al, 2014 ; Zheng, et al, 2018 ), cucurbiturils ( Praetorius, et al, 2008 ; Florea, et al, 2011 ; Barrow, et al, 2015 ; Sonzini, et al, 2017 ), and pillararenes ( Wang, et al, 2014 ; Bojtár, et al, 2015 ; Bojtár, et al, 2016 ; Hua, et al, 2016 ; Bojtár, et al, 2017 ; Hua, et al, 2018 ; Cai, et al, 2021 ; Wu, et al, 2021 ), are widely used as fluorescent probes in the majority of the FID-based sensing systems.…”

Nano-Theranostics Constructed from Terpyridine-Modified Pillar [5]arene-Based Supramolecular Amphiphile and Its Application in Both Cell Imaging and Cancer Therapy

“…Pillar[n]arenes are one type of classical macrocycles, which are synthesized from the hydroquinone-derivatives connected at 2,5-position by methylene groups [ 1 , 2 , 3 , 4 ]. Pillar[n]arenes have a rigid hydrophobic cavity with an adjustable size, which endows the pillar[n]arenes with rich host–guest properties [ 5 , 6 , 7 , 8 ].…”