RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

Sun, Zhong Sheng; Albrecht, Urs; Zhuchenko, Olga; Bailey, Jennifer M.; Eichele, Gregor; Lee, Cheng‐Chi

doi:10.1016/s0092-8674(00)80366-9

Cited by 631 publications

(426 citation statements)

References 44 publications

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“…Even though all three mPer isoforms cycle at both the mRNA and the protein levels in the SCN, mPer1 also shows region-specific and SCN-independent expression rhythm (von Gall et al, 2001;Sun et al, 1997;Iijima et al, 2002). Since SCN is thought to coordinate and regulate behavioral clocks in mammals, only a few studies have explored the SCN-independent rhythms of clock genes in the brain.…”

Section: Discussionmentioning

confidence: 99%

The Pineal Gland is Critical for Circadian Period1 Expression in the Striatum and for Circadian Cocaine Sensitization in Mice

Akhisaroğlu

Ahmed

et al. 2003

Neuropsychopharmacol

107

106

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Sensitization to psychostimulants can be influenced by circadian rhythms. The pineal gland, the main source of circadian melatonin synthesis, may influence behavioral sensitization to cocaine; mice with normal melatonin rhythms do not get sensitized at night. Clock genes such as Period1 (Per1) show rhythmic region-and strain-dependent expression in the mouse brain, and mice mutant for the Per1 gene lack cocaine sensitization. Here, for the first time we show circadian changes of PER1 protein levels in the mouse striatum, a brain region crucial for the development of locomotor sensitization to cocaine. In male C3H/HeJ mice, we found peak striatal PER1 protein levels during the day; this was preceded by a Per1 mRNA peak 16 h earlier. Pinealectomized mice did not show this circadian pattern. We analyzed circadian cocaine sensitization at times when striatal PER1 protein levels in control mice (naive and sham-pinealectomized) were high and low, respectively. Only mice with circadian changes in striatal Per1 expression showed the night-time absence of cocaine sensitization, whereas pinealectomized mice were without circadian changes in striatal Per1 and were sensitized to cocaine regardless of diurnal rhythm. Our results indicate that both the striatal circadian Per1 expression and diurnal locomotor cocaine sensitization are strongly influenced by pineal products. Since we found evidence for the expression of melatonin receptor mRNA in the striatum, we suggest that further studies on pineal-driven mechanisms will help us better understand the mechanisms of drug abuse and identify novel targets for the prevention and/or treatment of addictions.

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Section: Discussionmentioning

confidence: 99%

The Pineal Gland is Critical for Circadian Period1 Expression in the Striatum and for Circadian Cocaine Sensitization in Mice

Akhisaroğlu

Ahmed

et al. 2003

Neuropsychopharmacol

107

106

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“…The hepatic oscillator is centered on a pair of transcriptional activators, BMAL1 (also named Mop3) (Bunger et al, 2000;Hogenesch et al, 1998) and CLOCK (Gekakis et al, 1998;King et al, 1997) and two classes of repressors of the Period (Per) Shearman et al, 1997;Sun et al, 1997;Tei et al, 1997) and Cryptochrome (Cry) gene families (Griffin et al, 1999;Kume et al, 1999;van der Horst et al, 1999;Vitaterna et al, 1999) (Fig. 2).…”

Section: Transcriptional Network Of the Hepatic Circadian Oscillatormentioning

confidence: 99%

The role of clock genes and rhythmicity in the liver

Schmutz

Albrecht

Ripperger

2012

Molecular and Cellular Endocrinology

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The liver is the important organ to maintain energy homeostasis of an organism. To achieve this, many biochemical reactions run in this organ in a rhythmic fashion. An elegant way to coordinate the temporal expression of genes for metabolic enzymes relies in the link to the circadian timing system. In this fashion not only a maximum of synchronization is achieved, but also anticipation of daily recurring events is possible. Here we will focus on the input and output pathways of the hepatic circadian oscillator and discuss the recently found flexibility of its circadian transcriptional networks.

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“…Recent molecular dissection has revealed that the feedback loop is the basic concept of the circadian oscillator, conserved across the species from Neurospora and Drosophila to mice (Dunlap 1998a,b;Schibler 1998;Young 1998). A mammalian clock gene period consists of a family containing three members (mPer1, mPer2 and mPer3) (Shearman et al 1997;Sun et al 1997;Tei et al 1997;Takumi et al 1998a,b). The transcription of mPer1 is activated by the binding of the CLOCK/BMAL1 hetero-complex, both of which are bHLH-PAS proteins, to the E-boxes in the promoter region of mPer1 (Gekakis et al 1998).…”

Section: Introductionmentioning

confidence: 99%

A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1

et al. 1999

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Background: It is now becoming clear that the circadian rhythm of behaviours and hormones arises from a rhythm at the level of gene expression, and that mammals and Drosophila essentially use homologous genes as molecular gears in the control of circadian oscillation. In Drosophila, the period and timeless genes form a functional unit of the clock and its autoregulatory feedback loop for circadian rhythm. However, in mammals, the counterpart of timeless has not been found.

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RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

Cited by 631 publications

References 44 publications

The Pineal Gland is Critical for Circadian Period1 Expression in the Striatum and for Circadian Cocaine Sensitization in Mice

The Pineal Gland is Critical for Circadian Period1 Expression in the Striatum and for Circadian Cocaine Sensitization in Mice

The role of clock genes and rhythmicity in the liver

A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1

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