Rigid tumours contain soft cancer cells

Fuhs, Thomas; Wetzel, Franziska; Fritsch, Anatol; Li, Xinzhi; Stange, Roland; Pawlizak, Steve; Kießling, T.; Morawetz, Erik; Grosser, Steffen; Sauer, Frank; Lippoldt, Jürgen; Renner, Frédéric; Friebe, Sabrina; Zink, Mareike; Bendrat, Klaus; Braun, Jürgen; Oktay, Maja H.; Condeelis, John S.; Briest, Susanne; Wolf, Benjamin; Horn, Lars‐Christian; Höckel, Michael; Aktas, Bahriye; Manning, M. Lisa; Niendorf, Axel; Bi, Dapeng; Käs, Josef A.

doi:10.1038/s41567-022-01755-0

Cited by 57 publications

(70 citation statements)

References 80 publications

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“…While tumor tissues are usually stiff, cancer cells derived from patients and mice are soft. 61,68 Highly tumorigenic CSC-like tumor repopulating cells, as selected and enriched by 3D soft fibrin gels, are even softer relative to conventional cancer cells. 178 Cancer cells adopt their mechanical properties for invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…65,67 Although tumor cells are softer than normal cells, tumor tissues are often highly fibrotic, which makes the whole tumor exhibit a stiffer property than normal tissues. 68 Deposition, cross-linking and reconstruction of ECM are the main causes of tumor stiffening. In highly fibrotic tumors, CAFs play a key role in tumor stiffening as the ECM components are mainly produced by CAFs.…”

Section: Mechanical Stiffnessmentioning

confidence: 99%

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Modulating tumor mechanics with nanomedicine for cancer therapy

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Section: Mechanical Stiffnessmentioning

confidence: 99%

Modulating tumor mechanics with nanomedicine for cancer therapy

et al. 2023

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“…23 Thus, spatial heterogeneity of its mechanical properties is a further hallmark of cancer. 22 Although motile or unjammed cells give rise to areas of viscous fluid-like properties, a backbone of immobile or jammed cells as well as dense ECM fibers determine a tumor's overall solid and stiff behavior. Nonetheless, local tissue softening on the microlength scale promotes cancer cell unjamming and provides a mechanical signature that has been found to be highly specific for the aggressiveness of breast cancer.…”

Section: The Physical Hallmarks Of Cancermentioning

confidence: 99%

MR Elastography in Cancer

Guo¹,

Savic

Sack³

2023

Invest Radiol

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The mechanical traits of cancer include abnormally high solid stress as well as drastic and spatially heterogeneous changes in intrinsic mechanical tissue properties. Whereas solid stress elicits mechanosensory signals promoting tumor progression, mechanical heterogeneity is conducive to cell unjamming and metastatic spread. This reductionist view of tumorigenesis and malignant transformation provides a generalized framework for understanding the physical principles of tumor aggressiveness and harnessing them as novel in vivo imaging markers. Magnetic resonance elastography is an emerging imaging technology for depicting the viscoelastic properties of biological soft tissues and clinically characterizing tumors in terms of their biomechanical properties. This review article presents recent technical developments, basic results, and clinical applications of magnetic resonance elastography in patients with malignant tumors.

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“…Independent of the exact experimental settings, spheroids can be imaged continuously or at the beginning and end of the experiment only. A typical readout of such migration experiments is the increase in cell-covered area or tracking of individual migrating cells, to measure speed, morphology, or even migration of cells inside the spheroid (156)(157)(158)(159)(160). While such a model represents a more physiological approach, it is typically more time-consuming.…”

Section: Models To Study Cell Migrationmentioning

confidence: 99%

“…There, cells of one spheroid can migrate into another spheroid of the same or different cell type ( 155 , 159 , 160 ). In principle, similar parameters can be assessed as described before: the infiltration of one spheroid into the other, either as a bulk measurement or on a single-cell basis, and the time of complete fusion ( 159 , 160 ). All parameters can be considered proxies of cell migration and/or invasion.…”

Section: Models To Study Cell Migrationmentioning

confidence: 99%

MACC1-induced migration in tumors: Current state and perspective

2023

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Malignant tumors are still a global, heavy health burden. Many tumor types cannot be treated curatively, underlining the need for new treatment targets. In recent years, metastasis associated in colon cancer 1 (MACC1) was identified as a promising biomarker and drug target, as it is promoting tumor migration, initiation, proliferation, and others in a multitude of solid cancers. Here, we will summarize the current knowledge about MACC1-induced tumor cell migration with a special focus on the cytoskeletal and adhesive systems. In addition, a brief overview of several in vitro models used for the analysis of cell migration is given. In this context, we will point to issues with the currently most prevalent models used to study MACC1-dependent migration. Lastly, open questions about MACC1-dependent effects on tumor cell migration will be addressed.

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Rigid tumours contain soft cancer cells

Cited by 57 publications

References 80 publications

Modulating tumor mechanics with nanomedicine for cancer therapy

Modulating tumor mechanics with nanomedicine for cancer therapy

MR Elastography in Cancer

MACC1-induced migration in tumors: Current state and perspective

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