Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation

Gage, Nicole M.; Juranek, Jenifer; Filipek, Pauline A.; Osann, Kathryn; Flodman, Pamela; Isenberg, A. Lisette; Spence, M. Anne

doi:10.1007/s11689-009-9010-2

Cited by 62 publications

(41 citation statements)

References 50 publications

(76 reference statements)

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“…This is an important finding that not only reflects the literature in general, but also has implications for processing style and task difficulty in ASD participants. This supports many previous studies reporting atypical lateralization of language regions in ASD [Dawson et al, 1986;Eyler et al, 2012;Flagg et al, 2005;Gage et al, 2009;Herbert et al, 2002Herbert et al, , 2004Kana & Wadsworth, 2012;Kleinhans et al, Figure 4. (A) Between-group differences in brain activity during language tasks with equal group performance.…”

Section: Discussionsupporting

confidence: 91%

“…Altered asymmetry of the language association cortex has been reported in individuals with ASD at both structural [e.g., Gage et al, 2009;Herbert et al, 2002, Herbert et al, 2004 and functional levels [e.g., Kana & Wadsworth, 2012;Kleinhans, Muller, Cohen, & Courchesne, 2008;Tesink et al, 2009]. For example, toddlers with ASD were shown to have significantly greater right hemisphere (RH) activation, relative to control participants, in a speech perception task [Eyler, Pierce, & Courchesne, 2012;Redcay & Courchesne, 2008] suggesting early origins of hemispheric differences.…”

Section: Introductionmentioning

confidence: 99%

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Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

et al. 2016

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Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N = 328; TD: N = 324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. Autism Res 2016, 9: 1046-1057. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

et al. 2016

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“…Specifically, both SLI and ASD, particularly those with ALI, show reduced left hemisphere asymmetry in inferior frontal gyral regions (particularly pars opercularis), and exaggerated left asymmetry in posterior planum temporale [7,48,49,51,53]; though see Gage et al [54] for different findings. The volume of left inferior frontal gyral regions is generally reduced in ASD [55] and SLI [50], but the planum continues to show age-related increases in volume through adolescence in ASD based on cross-sectional data [51].…”

Section: Discussionmentioning

confidence: 99%

Defining language impairments in a subgroup of children with autism spectrum disorder

Tager–Flusberg

2015

Sci. China Life Sci.

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Autism spectrum disorder (ASD) is diagnosed on the basis of core impairments in pragmatic language skills, which are found across all ages and subtypes. In contrast, there is significant heterogeneity in language phenotypes, ranging from nonverbal to superior linguistic abilities, as defined on standardized tests of vocabulary and grammatical knowledge. The majority of children are verbal but impaired in language, relative to age-matched peers. One hypothesis is that this subgroup has ASD and co-morbid specific language impairment (SLI). An experiment was conducted comparing children with ASD to children with SLI and typically developing controls on aspects of language processing that have been shown to be impaired in children with SLI: repetition of nonsense words. Patterns of performance among the children with ASD and language impairment were similar to those with SLI, and contrasted with the children with ASD and no language impairment and typical controls, providing further evidence for the hypothesis that a subgroup of children with ASD has co-morbid SLI. The findings are discussed in the context of brain imaging studies that have explored the neural bases of language impairment in ASD and SLI, and overlap in the genes associated with elevated risk for these disorders. ASD, SLI, language impairment, comorbidity, brain imaging Citation:Tager-Flusberg H. Defining language impairments in a subgroup of children with autism spectrum disorder.

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“…This distinction affects a broad literature that uses anatomical criteria to estimate the size of human PAC (and the adjacent planum temporale) in relation to brain laterality, language and music abilities, and auditory-related pathologies, including dyslexia, autism, and schizophrenia (for review, see Abdul-Kareem and Sluming, 2008). By current convention, only the anterior division of duplicated HGs is included in PAC measurements (Rademacher et al et al, 1993;Penhune et al, 1996;Leonard et al, 2001;Schneider et al, 2002;Emmorey et al, 2003;Wong et al, 2008;Gage et al, 2009;Schneider et al, 2009;Warrier et al, 2009;Hubl et al, 2010) with the posterior division assigned instead to the planum temporale (Dorsaint-Pierre et al, 2006). The criteria proposed by Penhune et al (1996) (to consider only the anterior division as part of PAC if there is an SI extending half the length of HG) would wrongly exclude the posterior division of PAC (the entire hA1 subfield) in 7 out of 20 of our cases.…”

Section: Pac Spans Both Divisions Of Duplicated Heschl's Gyrimentioning

confidence: 96%

Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus

Costa¹,

Zwaag²,

Marques³

et al. 2011

J. Neurosci.

251

289

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The primary auditory cortex (PAC) is central to human auditory abilities, yet its location in the brain remains unclear. We measured the two largest tonotopic subfields of PAC (hA1 and hR) using high-resolution functional MRI at 7 T relative to the underlying anatomy of Heschl's gyrus (HG) in 10 individual human subjects. The data reveals a clear anatomical-functional relationship that, for the first time, indicates the location of PAC across the range of common morphological variants of HG (single gyri, partial duplications, and complete duplications). In 20/20 individual hemispheres, two primary mirror-symmetric tonotopic maps were clearly observed with gradients perpendicular to HG. PAC spanned both divisions of HG in cases of partial and complete duplications (11/20 hemispheres), not only the anterior division as commonly assumed. Specifically, the central union of the two primary maps (the hA1-R border) was consistently centered on the full Heschl's structure: on the gyral crown of single HGs and within the sulcal divide of duplicated HGs. The anatomicalfunctional variants of PAC appear to be part of a continuum, rather than distinct subtypes. These findings significantly revise HG as a marker for human PAC and suggest that tonotopic maps may have shaped HG during human evolution. Tonotopic mappings were based on only 16 min of fMRI data acquisition, so these methods can be used as an initial mapping step in future experiments designed to probe the function of specific auditory fields.

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Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation

Cited by 62 publications

References 50 publications

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

Defining language impairments in a subgroup of children with autism spectrum disorder

Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus

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