Right ventricular systolic function and ventricular interaction during acute embolisation of the left anterior descending coronary artery in sheep

Jerzewski, Anastazia; Steendijk, Paul; Pattynama, Peter M. T.; Leeuwenburgh, Boudewijn P.J.; Roos, Albert de; Baan, Jan

doi:10.1016/s0008-6363(99)00054-1

Cited by 17 publications

(14 citation statements)

References 39 publications

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“…The role of the right ventricle has largely been ignored in MI studies; however, recent studies have revealed that diminished right ventricular function has been observed as a consequence of the ischemic LV. 39 As a result, we believe that the stress incurred in the ␣-E-cat cKO right ventricle by the MI was sufficient to cause free wall rupture. Because similar infarct sizes were observed in ␣-E-cat cKO and WT mice, this further reinforced that the molecular disruptions within the adherens junction complex are key factors regulating the structural susceptibility of the ventricle.…”

Section: Discussionmentioning

confidence: 95%

α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture

et al. 2006

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Background-␣-E-catenin is a cell adhesion protein, located within the adherens junction, thought to be essential in directly linking the cadherin-based adhesion complex to the actin cytoskeleton. Although ␣-E-catenin is expressed in the adherens junction of the cardiomyocyte intercalated disc, and perturbations in its expression are observed in models of dilated cardiomyopathy, its role in the myocardium remains unknown. Methods and Results-To determine the effects of ␣-E-catenin on cardiomyocyte ultrastructure and disease, we generated cardiac-specific ␣-E-catenin conditional knockout mice (␣-E-cat cKO). ␣-E-cat cKO mice displayed progressive dilated cardiomyopathy and unique defects in the right ventricle. The effects on cardiac morphology/function in ␣-E-cat cKO mice were preceded by ultrastructural defects in the intercalated disc and complete loss of vinculin at the intercalated disc. ␣-E-cat cKO mice also revealed a striking susceptibility of the ventricular free wall to rupture after myocardial infarction. Conclusions-These results demonstrate a clear functional role for ␣-E-catenin in the cadherin/catenin/vinculin complex in the myocardium in vivo. Ablation of ␣-E-catenin within this complex leads to defects in cardiomyocyte structural integrity that result in unique forms of cardiomyopathy and predisposed susceptibility to death after myocardial stress. These studies further highlight the importance of studying the role of ␣-E-catenin in human cardiac injury and cardiomyopathy in the future.

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Section: Discussionmentioning

confidence: 95%

α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture

et al. 2006

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“…LV PV loops shifted to the right, in agreement with experiments. 17 Because outflow of the RV was larger than that of the LV (LV outflow was reduced), pulmonic pressures and volumes were increasing, and thus preload of the LA and LV increased. This in turn increased LV end-diastolic pressures and volumes (which results in the right-shift of the loops).…”

Section: Physiological Resultsmentioning

confidence: 99%

“…This phenomenon has also been shown experimentally. 17 Owing to reduced LV outflow, systemic volumes were decreasing. But because RV outflow was also reduced, flow into the RA was still larger than outflow of the RA, increasing RA volume.…”

Section: Physiological Resultsmentioning

confidence: 99%

Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

et al. 2006

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In this study we present a novel, robust method to couple finite element (FE) models of cardiac mechanics to systems models of the circulation (CIRC), independent of cardiac phase. For each time step through a cardiac cycle, left and right ventricular pressures were calculated using ventricular compliances from the FE and CIRC models. These pressures served as boundary conditions in the FE and CIRC models. In succeeding steps, pressures were updated to minimize cavity volume error (FE minus CIRC volume) using Newton iterations. Coupling was achieved when a predefined criterion for the volume error was satisfied. Initial conditions for the multi-scale model were obtained by replacing the FE model with a varying elastance model, which takes into account direct ventricular interactions. Applying the coupling, a novel multi-scale model of the canine cardiovascular system was developed. Global hemodynamics and regional mechanics were calculated for multiple beats in two separate simulations with a left ventricular ischemic region and pulmonary artery constriction, respectively. After the interventions, global hemodynamics changed due to direct and indirect ventricular interactions, in agreement with previously published experimental results. The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system.

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“…Recently, MRI-derived LV pressure-volume loops were proposed as an alternative to conductance catheter techniques by Pattynama et al 20 and then applied by Jerzewski et al 24,25 to the RV. A similar MRI approach was used in the present study.…”

Section: Technical Aspects Of This Studymentioning

confidence: 99%

“…26 Unfortunately, this method would be limited to patients without intracardiac shunts. In the studies by Pattynama et al 20 and Jerzewski et al, 24,25 pressure-volume loops were derived with multislice cine MRI during 2 different steady-state conditions of preload. Changes in preload were achieved by infusion of nitroprusside or by volume loading.…”

Section: Technical Aspects Of This Studymentioning

confidence: 99%

Magnetic Resonance Imaging Analysis of Right Ventricular Pressure-Volume Loops

Küehne

Yilmaz²,

Steendijk³

et al. 2004

Circulation

326

125

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Background-The aims of this study were to validate MRI-derived right ventricular (RV) pressure-volume loops for assessment of RV myocardial contractility and then to apply this technique in patients with chronic RV pressure overload for assessment of myocardial contractility, ventricular pump function, and VA coupling. Methods and Results-Flow-directed catheters were guided under MR fluoroscopy (1.5 T) into the RV for invasive pressure measurements. Simultaneously, ventricular volumes and myocardial mass were assessed from cine MRI. From sampled data, RV pressure-volume loops were constructed, and maximal ventricular elastance indexed to myocardial mass (E max_i ) was derived by use of a single-beat estimation method. This MRI method was first validated in vivo (6 swine), with conductance techniques used as reference. Bland-Altman test showed good agreement between methods (E max_i ϭ5.1Ϯ0.5 versus 5.8Ϯ0.7 mm Hg · mL Ϫ1 · 100 g

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Right ventricular systolic function and ventricular interaction during acute embolisation of the left anterior descending coronary artery in sheep

Cited by 17 publications

References 39 publications

α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture

α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture

Coupling of a 3D Finite Element Model of Cardiac Ventricular Mechanics to Lumped Systems Models of the Systemic and Pulmonic Circulation

Magnetic Resonance Imaging Analysis of Right Ventricular Pressure-Volume Loops

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