Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging

Moreira, Henrique T.; Volpe, Gustavo Jardim; Marin-Neto, José Antônio; Nwabuo, Chike C.; Ambale-Venkatesh, Bharath; Gali, Luís Gustavo; Almeida-Filho, Oswaldo C.; Romano, Minna Moreira Dias; Pazin‐Filho, Antônio; Maciel, Benedito Carlos; Lima, João A.C.; Schmidt, André

doi:10.1016/j.echo.2017.01.010

Cited by 22 publications

(27 citation statements)

References 37 publications

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“…In addition, free-RVLS is unaffected by endocardial border delineation which may have limited the reliability of RVFAC. 37 In the present study, free-RVLS showed the lower diagnostic accuracy (AUC of 0.86, sensitivity of 70%, and specificity of 92%) than that of previous report. 16,17,35 In addition, free-RVLS assesses the only RV lateral systolic function while RVLS including not only free wall but also septum may reduce the specificity for the detection of reduced RVEF compared to free-RVLS.…”

Section: Rv Free Wall Longitudinal Strain By Speckletracking Echocacontrasting

confidence: 83%

“…16,17,35 In addition, free-RVLS assesses the only RV lateral systolic function while RVLS including not only free wall but also septum may reduce the specificity for the detection of reduced RVEF compared to free-RVLS. 37 In the present study, free-RVLS showed the lower diagnostic accuracy (AUC of 0.86, sensitivity of 70%, and specificity of 92%) than that of previous report. 23,34 It might be explained in part by image quality or heterogenous study population.…”

Section: Rv Free Wall Longitudinal Strain By Speckletracking Echocacontrasting

confidence: 83%

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Value of tissue‐tracking tricuspid annular plane by speckle‐tracking echocardiography for the assessment of right ventricular systolic dysfunction

et al. 2018

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Background: Assessment of right ventricular (RV) function remains challenging because of its complex geometry. Application of speckle-tracking echocardiography (STE) to the tricuspid annulus provides rapid and automated assessment of the midpoint of the tricuspid annular plane displacement (TAD). The aim of this study was to investigate the value of tissue-tracking TAD for the assessment of RV systolic dysfunction. Methods:We retrospectively studied 61 patients in whom RV ejection fraction (EF) measured by 3-dimensional echocardiography was performed. STE-derived displacement of the midpoint between the septal and lateral tricuspid annulus and its percentage of RV length at end-diastole (MTAD) were automatically assessed. We performed comparative analyses between the RVEF ≥45% group and the RVEF <45% group in each parameter for the assessment of RV systolic function.Results: MTAD was successfully assessed in 56 (91.2%). According to receiver operating characteristics analysis, RVEF <45% was best detected by MTAD <14.7% with area under curve (AUC) 0.97, sensitivity 93%, specificity 95%, followed by RV free wall longitudinal strain (AUC 0.86), RV fractional area change (AUC 0.84), tricuspid annular plane systolic excursion (AUC 0.79), and systolic peak velocity of tricuspid annulus (AUC 0.70), although there was no significant difference between MTAD and RV free wall strain (P = 0.14). Conclusion:The present study showed that MTAD was simple index and useful for the assessment of RV systolic dysfunction. K E Y W O R D Sright ventricular function, three-dimensional echocardiography | 111 MANIWA et Al.

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Section: Rv Free Wall Longitudinal Strain By Speckletracking Echocacontrasting

confidence: 83%

Section: Rv Free Wall Longitudinal Strain By Speckletracking Echocacontrasting

confidence: 83%

Value of tissue‐tracking tricuspid annular plane by speckle‐tracking echocardiography for the assessment of right ventricular systolic dysfunction

et al. 2018

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“…RV free wall strain ( Figure 13B) is a novel technique for evaluating RV systolic function in ChD. 113 The Right Ventricle in ChD. RV involvement is common in ChHD and has been described even in the indeterminate form by nuclear and biopsy studies.…”

Section: Vc Rv Functionmentioning

confidence: 99%

“…116 The value of RV strain is still unclear in ChD. 61,113 Occasionally, RV apical aneurysm is the only detectable abnormality. 91 RV Evaluation by CMR.…”

Section: Vc Rv Functionmentioning

confidence: 99%

Recommendations for Multimodality Cardiac Imaging in Patients with Chagas Disease: A Report from the American Society of Echocardiography in Collaboration With the InterAmerican Association of Echocardiography (ECOSIAC) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DIC-SBC)

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Barbosa

et al. 2018

Journal of the American Society of Echocardiography

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“…Echocardiographic cutoffs to differentiate asymptomatic phases from myocardial impairment ones have not been clearly established . The need of comparative studies to estimate the sensitivity and specificity of echocardiographic (Echo) abnormalities have been suggested in order to provide an index of progression of the disease .…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy

et al. 2020

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Background Chronic Chagas cardiomyopathy (CCM) is characterized by a unique type of cardiac involvement. Few studies have characterized echocardiographic (Echo) transitions from the indeterminate Chagas disease (ChD) form to CCM. The objective of this study was to identify the best cutoffs in multiple Echo parameters, speckle tracking, and N‐terminal pro B‐type natriuretic peptide (NT‐proBNP) to distinguish patients without CCM (stage A) vs patients with myocardial involvement (stages B, C, or D). Methods Cross‐sectional study conducted in 273 consecutive patients with different CCM stages. Echo parameters, NT‐proBNP, and other clinical variables were measured. Logistic regression models (dichotomized in stage A versus B, C, and D) adjusted for age, sex, body mass index, and NT‐proBNP were performed. Results Left ventricular global longitudinal strain (LV‐GLS), mitral flow E velocity, LV mass index, and NT‐proBNP identified early changes that differentiated stages A vs B, C, and D. The LV‐GLS with a cutoff −20.5% showed the highest performance (AUC 92.99%; accuracy 84.56% and negative predictive value (NPV) 88.82%), which improved when it was additionally adjusted by NT‐proBNP with a cutoff −20.0% (AUC 94.30%; accuracy 88.42% and NPV 93.55%). Conclusions Our findings suggest that Echo parameters and NT‐proBNP may be used as diagnostic variables in detecting the onset of myocardial alterations in patients with the indeterminate stage of ChD. LV‐GLS was the more accurate measurement regarding stage A differentiation from the stages B, C, and D. Prospective longitudinal studies are needed to validate these findings.

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Right Ventricular Systolic Dysfunction in Chagas Disease Defined by Speckle-Tracking Echocardiography: A Comparative Study with Cardiac Magnetic Resonance Imaging

Cited by 22 publications

References 37 publications

Value of tissue‐tracking tricuspid annular plane by speckle‐tracking echocardiography for the assessment of right ventricular systolic dysfunction

Value of tissue‐tracking tricuspid annular plane by speckle‐tracking echocardiography for the assessment of right ventricular systolic dysfunction

Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy

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