Right Ventricular Strain Is Associated With Increased Length of Stay After Tetralogy of Fallot Repair

Srinivasan, R.; Faerber, Jennifer; DeCost, Grace; Zhang, Xuemei; DiLorenzo, Michael P.; Goldmuntz, Elizabeth; Fogel, Mark A.; Mercer‐Rosa, Laura

doi:10.4250/jcvi.2021.0069

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…It can detect subtle changes in ventricular function before EF is reduced [ 10 , 11 , 12 ]. Furthermore, strain measures seem to have independent prognostic value and are able to predict mortality better than established parameters such as RV-EF or tricuspid annular plain systolic excursion (TAPSE) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. However, the physiological correlation of RV strain still remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings

et al. 2022

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Cardiac magnetic resonance (CMR) is currently the gold standard for evaluating right ventricular (RV) function, which is critical in patients with pulmonary hypertension. CMR feature-tracking (FT) strain analysis has emerged as a technique to detect subtle changes. However, the dependence of RV strain on load is still a matter of debate. The aim of this study was to measure the afterload dependence of RV strain and to correlate it with surrogate markers of contractility in a cohort of patients with chronic thromboembolic pulmonary hypertension (CTEPH) under two different loading conditions before and after pulmonary endarterectomy (PEA). Between 2009 and 2022, 496 patients with 601 CMR examinations were retrospectively identified from our CTEPH cohort, and the results of 194 examinations with right heart catheterization within 24 h were available. The CMR FT strain (longitudinal (GLS) and circumferential (GCS)) was computed on steady-state free precession (SSFP) cine CMR sequences. The effective pulmonary arterial elastance (Ea) and RV chamber elastance (Ees) were approximated by dividing mean pulmonary arterial pressure by the indexed stroke volume or end-systolic volume, respectively. GLS and GCS correlated significantly with Ea and Ees/Ea in the overall cohort and individually before and after PEA. There was no general correlation with Ees; however, under high afterload, before PEA, Ees correlated significantly. The results show that RV GLS and GCS are highly afterload-dependent and reflect ventriculoarterial coupling. Ees was significantly correlated with strain only under high loading conditions, which probably reflects contractile adaptation to pulsatile load rather than contractility in general.

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Section: Introductionmentioning

confidence: 99%

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings

et al. 2022

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Speckle tracking echocardiography: a reliable tool for right ventricle function evaluation in severe tricuspid regurgitation

Lee

2024

J Cardiovasc Imaging

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Neurodevelopment in patients with repaired tetralogy of Fallot

Mercer-Rosa,

Favilla

2024

Front. Pediatr.

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Neurodevelopmental sequelae are prevalent and debilitating for patients with congenital heart defects. Patients born with tetralogy of Fallot (TOF) are susceptible for abnormal neurodevelopment as they have several risk factors surrounding the perinatal and perioperative period. Some risk factors have been well described in other forms of congenital heart defects, including transposition of the great arteries and single ventricle heart disease, but they have been less studied in the growing population of survivors of TOF surgery, particularly in infancy and childhood. Adolescents with TOF, even without a genetic syndrome, exhibit neuro-cognitive deficits in executive function, visual-spatial skills, memory, attention, academic achievement, social cognition, and problem-solving, to mention a few. They also have greater prevalence of anxiety disorder, disruptive behavior and attention-deficit hyperactivity disorder. These deficits impact their academic performance, social adjustment, and quality of life, thus resulting in significant stress for patients and their families. Further, they can impact their social adjustment, employment and career development as an adult. Infants and younger children can also have significant deficits in gross and fine motor skills, cognitive deficits and abnormal receptive language. Many of the risk factors associated with abnormal neurodevelopment in these patients are not readily modifiable. Therefore, patients should be referred for evaluation and early intervention to help maximize their neurodevelopment and improve overall outcomes. More study is needed to identify potentially modifiable risk factors and/or mediators of neurodevelopment, such as environmental and socio-economic factors.

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Right Ventricular Strain Is Associated With Increased Length of Stay After Tetralogy of Fallot Repair

Cited by 4 publications

References 25 publications

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings

Speckle tracking echocardiography: a reliable tool for right ventricle function evaluation in severe tricuspid regurgitation

Neurodevelopment in patients with repaired tetralogy of Fallot

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