Right Ventricular Strain before and after Pulmonary Thromboendarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension

Marston, Nicholas; Brown, Jason P.; Olson, Nicholas; Auger, William R.; Madani, Michael M.; Wong, Darrin; Raisinghani, Ajit; DeMaria, Anthony N.; Blanchard, Daniel G.

doi:10.1111/echo.12812

Cited by 25 publications

(22 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…found a similar decrease (i.e., a change toward 0%) in RV basal free wall strain and lack of correlation with PVR after PTE. Thus, although some echocardiographic parameters correlate well with successful PTE (e.g., tricuspid regurgitation velocity, RV Tei index), others clearly do not (e.g., RV free wall strain, TAPSE) . As our study had only short‐term follow‐up, we cannot comment on longer‐term RV remodeling post‐PTE …”

Section: Discussionmentioning

confidence: 77%

See 1 more Smart Citation

Tricuspid annular plane systolic excursion in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 77%

“…They also found mild improvement in TAPSE after subsequent follow‐up, but to a level less than preoperative values. In addition, Marston et al . found a similar decrease (i.e., a change toward 0%) in RV basal free wall strain and lack of correlation with PVR after PTE.…”

Section: Discussionmentioning

confidence: 86%

Tricuspid annular plane systolic excursion in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Speckle tracking is today widely accepted in the context of functional assessment of the left ventricle. In the last few years, there has been increasing interest in the use of this technique for RV analysis [31][32][33][34][35][36][37][38]. Compared to other markers of function, strain measurements have been reported to be angle-independent, less loadsensitive and able to accurately reflect regional deformation.…”

Section: Fig 4 Results Of Linear Regression (Top) and Bland-altman (mentioning

confidence: 99%

Semi-automated echocardiographic quantification of right ventricular size and function

Medvedofsky

Addetia

Hamilton

et al. 2015

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

Although parameters of right ventricular (RV) size and function are clinically important, echocardiographic assessment of this chamber is complex. Existing quantitative approaches rely on manual measurements performed on different images, and are thus time-consuming. Consequently, in clinical practice, qualitative assessment is usually used instead. We tested a new approach for automated measurements of RV size and function using speckle tracking by comparing them to the conventional manual methodology. Transthoracic images were obtained in 149 patients with a wide range of RV size and function, and were analyzed by an expert using conventional techniques to obtain RV end-diastolic and end-systolic areas, fractional area change, dimensions (basal and mid-cavity diameters and length), tricuspid annular plane systolic excursion and peak systolic velocity. Same parameters were obtained using the semi-automated software (Epsilon Imaging), which requires tracing of the RV endocardial boundary in a single frame in the RV focused view. Fifteen patients were excluded due to image quality (90% feasibility). Time required for the automated analysis was approximately 30 s per patient, compared to 4 min for conventional analysis. The parameters obtained with the semi-automated approach were in good agreement with manual measurements: r-values 0.79-0.95 for RV size and 0.70-0.74 for function indices and biases of 2-22% of the mean measured values, which were comparable to the intrinsic variability of the conventional technique. In conclusion, the semi-automated technique is feasible, fast and provides quantitative parameters of RV size and function, which are comparable to conventional measurements.

show abstract

“…The assessment of RV longitudinal systolic function by GLS of the RV seems promising, but future studies must determine the usefulness of this parameter as a marker of systolic function following heart surgery, including surgery in CTEPH patients undergoing PEA. Marston N et al demonstrated that RV basal strain paradoxically became less negative following PEA and should therefore not be used as a marker for success early after PEA …”

Section: Discussionmentioning

confidence: 99%

Long‐term changes of resting and exercise right ventricular systolic performance in patients with chronic thromboembolic pulmonary hypertension following pulmonary thromboendarterectomy – A two‐dimensional and three‐dimensional echocardiographic study

et al. 2019

View full text Add to dashboard Cite

Aims To characterize right ventricular (RV) geometry and function in chronic thromboembolic pulmonary hypertension (CTEPH) patients at rest and during exercise before pulmonary thromboendarterectomy (PEA), and at 3 and 12 months after PEA using two‐dimensional and three‐dimensional echocardiography with reference to clinical performance and exercise capacity. Methods and results Forty subjects (20 CTEPH patients and 20 controls) were enrolled between December 2014 and January 2017. Three‐dimensional echocardiography demonstrated a significant reduction and normalization of end‐diastolic and end‐systolic RV volumes in CTEPH patients 12 months after PEA. RV systolic function improved after PEA; however, tricuspid annular plane systolic excursion (TAPSE) (baseline 18 ± 6 mm vs 15 ± 3 mm at 12 months after PEA, P < .05) and tricuspid lateral annular systolic velocity (RV‐S′) (baseline −8.3 ± 2.1 cm/s vs −7.2 ± 1.3 cm/s at 12 months after PEA, P < .05) declined significantly after PEA. Tricuspid regurgitation gradient was 64 ± 21 mm Hg at baseline, 40 ± 14 mm Hg at 3 months, and 30 ± 13 at 12 months, P < .00001. RV free‐wall longitudinal strain at peak exercise was significantly increased from baseline (−10.6 ± 5.5%) to 12 months of follow‐up (−15.8 ± 5.2%), P < .005. Physical exercise capacity, measured as peak oxygen uptake, was significantly increased and correlated directly with improvement of resting and exercise‐induced RV‐EF. Conclusion Improvement of RV geometry and systolic function, along with the reduction of systolic pulmonary pressure, can be expected following PEA in CTEPH patients during long‐term follow‐up. Improvement of RV myocardial contractility after PEA was only revealed at peak exercise over time. Importantly, physical exercise capacity was significantly increased and was found to be directly correlated with improvement of resting and exercise‐induced RV‐EF.

show abstract

Right Ventricular Strain before and after Pulmonary Thromboendarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension

Cited by 25 publications

References 26 publications

Tricuspid annular plane systolic excursion in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

Tricuspid annular plane systolic excursion in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

Semi-automated echocardiographic quantification of right ventricular size and function

Long‐term changes of resting and exercise right ventricular systolic performance in patients with chronic thromboembolic pulmonary hypertension following pulmonary thromboendarterectomy – A two‐dimensional and three‐dimensional echocardiographic study

Contact Info

Product

Resources

About