Right ventricular preload and afterload challenge induces contractile dysfunction and arrhythmia in isolated hearts of dystrophin‐deficient male mice
Andrew Behrmann,
Jessica Cayton,
Matthew R. Hayden
et al.
Abstract:Duchenne muscular dystrophy (DMD) is an X‐linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV). Thus, RV dysfunction in DMD develops early in disease progression. Herein, we deliver a 30‐min sustained RV preload/afterload challenge to isolated hearts of wild‐type (Wt) and dystrophic (Dmdmdx‐4Cv) mice at both young (2–6 month) and middle‐age (8–12 month) to test the hypothesis that the dystrophi… Show more
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