Right ventricular myocardial involvement in either physiological or pathological left ventricular hypertrophy: an ultrasound speckle-tracking two-dimensional strain analysis

D’Andrea, Antonello; Caso, Pio; Bossone, Eduardo; Scarafile, Raffaella; Riegler, Lucia; Salvo, Giovanni Di; Gravino, Rita; Cocchia, Rosangela; Castaldo, Francesco; Salerno, Gemma; Golia, Enrica; Limongelli, Giuseppe; Corato, Giuseppe De; Cuomo, Sergio; Pacileo, Giuseppe; Russo, Maria Giovanna; Calabrò, Raffaele

doi:10.1093/ejechocard/jeq007

Cited by 69 publications

(27 citation statements)

References 43 publications

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“…The clear prognostic importance of RV function in various diseases has encouraged investigations about new echocardiographic methods for accurate diagnosis of RV failure (2628). In a recently published article, D’andrea et al (29) showed that 2-D-STE-derived RV myocardial systolic deformation is influenced in HCM patients. There was a negative association between inter-ventricular septal thickness and RV global longitudinal strain in HCM patients.…”

Section: Discussionmentioning

confidence: 99%

Right ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study

Çinçin¹,

Tigen²,

Karaahmet³

et al. 2015

Anatol J Cardiol

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Objective:The aim of this study was to explore right ventricular (RV) mechanical function in patients with hypertrophic cardiomyopathy (HCM) by 2-D speckle tracking echocardiography (2-D-STE).Methods:Forty-three patients with HCM (mean age 48, 17 females) and 40 healthy subjects were consecutively included in this cross-sectional study. The diagnosis of HCM was based on the presence of typical clinical, electrocardiographic (ECG), and echocardiographic features. Patients with LV systolic impairment, significant valvular disease, history of coronary artery disease, hypertension, malignancy, and chronic obstructive pulmonary disease were excluded. Right and left ventricular (LV) function was assessed by tissue Doppler imaging (TDI) and 2-D-STE. Hypertrophic cardiomyopathy patients were divided into two groups according to ACC/ESC guidelines (LVOT gradient below and above 30 mm Hg). Student t-test was used to compare differences between groups. Non-parametric tests (Mann-Whitney U) were used in cases of abnormal distribution.Results:Hypertrophic cardiomyopathy patients had a significantly larger right atrium and RV diameters compared to controls. Mean pulmonary artery pressures (mPAB) were significantly higher in HCM patients (19.01±13.09 mm Hg vs. 8.40±4.50 mm Hg; p<0.001). Although RV Sm measure-ments were similar, RV strain measurements (-28.51±5.36% vs. -32.06±7.65%; p=0.016) were significantly lower in HCM patients. Left ventricular global longitudinal, radial, and circumferential strain values were also significantly different between the two groups (-20.50±3.58% vs. -24.12±3.40%; p<0.001, 38.18±12.67% vs. 44.80±10.15%; p=0.012, -21.94±4.28% vs. -23.91±3.95%; p=0.036 consecutively). Rotational movement of LV in each apical, mid-, and basal left ventricular segment was determined, and only mid-ventricular rotation of the HCM patients was more clockwise (-1.71±2.16 ° vs. 0.04±1.72 p<0.001). Although mPAP measurements were higher in HCM patients with significant LVOT obstruction (21.52±13.26 mm Hg vs. 12.31±10.53 mm Hg; p=0.049), none of the other TDI or 2-D-STE parameters was significantly different between groups.Conclusion:Speckle tracking echocardiography-derived right ventricular systolic function is impaired in HCM patients when compared with healthy subjects. However, RV systolic function is not affected form LVOT obstruction and left ventricular rotation dynamics in HCM patients.

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Section: Discussionmentioning

confidence: 99%

Right ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study

Çinçin¹,

Tigen²,

Karaahmet³

et al. 2015

Anatol J Cardiol

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“…A few recent studies have utilized RV myocardial speckle tracking to differentiate between physiology and pathology 44–46 and to identify interventional changes 47 . Recent work reported a 36% difference in peak RV ɛ between athletic subjects and those with hypertrophic cardiomyopathy 45 and on the basis of the current data this likely represents a “real” or meaningful difference Conversely, others have demonstrated a difference of 6% in peak RV ɛ between elite athletes and controls 44 and only an 8% reduction in RV ɛ following percutaneous closure of an atrial septal defect 47 . The findings from both of these studies should be interpreted very cautiously on the basis of the current findings for intraobserver variability in this parameter.…”

Section: Discussionmentioning

confidence: 99%

Intraobserver Reliability of Two‐Dimensional Ultrasound Derived Strain Imaging in the Assessment of the Left Ventricle, Right Ventricle, and Left Atrium of Healthy Human Hearts

2012

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“…Speckle tracking echocardiography of the right ventricle has been already applied to the assessment of the athlete's heart . Recently, D'Andrea et al .…”

Section: Discussionmentioning

confidence: 99%

Nonsymmetric Myocardial Contribution to Supranormal Right Ventricular Function in the Athlete's Heart: Combined Assessment by Speckle Tracking and Real Time Three‐Dimensional Echocardiography

et al. 2013

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Right ventricular myocardial involvement in either physiological or pathological left ventricular hypertrophy: an ultrasound speckle-tracking two-dimensional strain analysis

Cited by 69 publications

References 43 publications

Right ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study

Right ventricular function in hypertrophic cardiomyopathy: A speckle tracking echocardiography study

Intraobserver Reliability of Two‐Dimensional Ultrasound Derived Strain Imaging in the Assessment of the Left Ventricle, Right Ventricle, and Left Atrium of Healthy Human Hearts

Nonsymmetric Myocardial Contribution to Supranormal Right Ventricular Function in the Athlete's Heart: Combined Assessment by Speckle Tracking and Real Time Three‐Dimensional Echocardiography

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