Right Ventricular Myocardial Biomarkers in Human Heart Failure

Salvo, Thomas G. Di; Yang, Kai-Chien; Brittain, Evan L.; Absi, Tarek; Maltais, Simon; Hemnes, Anna R.

doi:10.1016/j.cardfail.2015.02.005

Cited by 51 publications

(53 citation statements)

References 30 publications

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“…In recent years, multiple studies have investigated the transcriptome signature of heart failure (HF). Differential expression analysis was conducted comparing whole transcriptome profiles between explanted human HF right ventricles (RV) and five unused donor human heart RVs . STEAP4, SPARCL1 , and VSIG4 were identified as potential RV myocardial biomarkers in human HF .…”

Section: Breakthrough Discoveries With Rna‐seqmentioning

confidence: 99%

“…Differential expression analysis was conducted comparing whole transcriptome profiles between explanted human HF right ventricles (RV) and five unused donor human heart RVs . STEAP4, SPARCL1 , and VSIG4 were identified as potential RV myocardial biomarkers in human HF . The same group also identified long noncoding RNA differentially expressed between normal vs. HF RVs .…”

Section: Breakthrough Discoveries With Rna‐seqmentioning

confidence: 99%

“…72 STEAP4, SPARCL1, and VSIG4 were identified as potential RV myocardial biomarkers in human HF. 72 The same group also identified long noncoding RNA differentially expressed between normal vs. HF RVs. 73 Another study used transcriptomics data, generated by RNA-Seq and microarrays, to identify novel myocardial gene expression signatures of HF.…”

Section: Breakthrough Discoveries With Rna-seqmentioning

confidence: 99%

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Whole Transcriptome Profiling: An RNA‐Seq Primer and Implications for Pharmacogenomics Research

Sá

Sadée

2017

Clinical Translational Sci

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Section: Breakthrough Discoveries With Rna‐seqmentioning

confidence: 99%

Section: Breakthrough Discoveries With Rna‐seqmentioning

confidence: 99%

Section: Breakthrough Discoveries With Rna-seqmentioning

confidence: 99%

See 1 more Smart Citation

Whole Transcriptome Profiling: An RNA‐Seq Primer and Implications for Pharmacogenomics Research

Sá

Sadée

2017

Clinical Translational Sci

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“…Preclinical studies have been challenged by limitations of commonly used animal models that were developed to study pulmonary vascular disease rather than RV dysfunction or biventricular HF. Some studies have sought to identify molecular signatures of RVF, using animal models (13)(14)(15)(16)(17) or human tissue (18)(19)(20). Most of these were limited to animal models or patients with RV dysfunction but not RVF (13,14,16,18,19).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have sought to identify molecular signatures of RVF, using animal models (13)(14)(15)(16)(17) or human tissue (18)(19)(20). Most of these were limited to animal models or patients with RV dysfunction but not RVF (13,14,16,18,19). These prior studies did not pursue experimental validation or mechanistic studies of their potential molecular signatures of RV dysfunction (13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

WIPI1 is a conserved mediator of right ventricular failure

Tzimas¹,

Rau²,

Buergisser³

et al. 2019

JCI Insight

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Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation‐contraction coupling

et al. 2022

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Excitation‐contraction coupling (ECC) is the physiological process in which an electrical signal originating from the central nervous system is converted into muscle contraction. In skeletal muscle tissue, the key step in the molecular mechanism of ECC initiated by the muscle action potential is the cooperation between two Ca2+ channels, dihydropyridine receptor (DHPR; voltage‐dependent L‐type calcium channel) and ryanodine receptor 1 (RyR1). These two channels were originally postulated to communicate with each other via direct mechanical interactions; however, the molecular details of this cooperation have remained ambiguous. Recently, it has been proposed that one or more supporting proteins are in fact required for communication of DHPR with RyR1 during the ECC process. One such protein that is increasingly believed to play a role in this interaction is the SH3 and cysteine‐rich domain‐containing protein 3 (STAC3), which has been proposed to bind a cytosolic portion of the DHPR α1S subunit known as the II–III loop. In this work, we present direct evidence for an interaction between a small peptide sequence of the II–III loop and several residues within the SH3 domains of STAC3 as well as the neuronal isoform STAC2. Differences in this interaction between STAC3 and STAC2 suggest that STAC3 possesses distinct biophysical features that are potentially important for its physiological interactions with the II–III loop. Therefore, this work demonstrates an isoform‐specific interaction between STAC3 and the II–III loop of DHPR and provides novel insights into a putative molecular mechanism behind this association in the skeletal muscle ECC process.

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Right Ventricular Myocardial Biomarkers in Human Heart Failure

Abstract: Unbiased, comprehensive profiling of the RV transcriptome by RNA-seq suggests structural changes and abnormalities in inflammatory processes and yields specific, novel HF RV vs HF LV myocardial biomarkers not previously identified by more limited transcriptome profiling approaches.

Cited by 51 publications

References 30 publications

Whole Transcriptome Profiling: An RNA‐Seq Primer and Implications for Pharmacogenomics Research

Whole Transcriptome Profiling: An RNA‐Seq Primer and Implications for Pharmacogenomics Research

WIPI1 is a conserved mediator of right ventricular failure

Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation‐contraction coupling

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