Right ventricular metastatic tumor from a primary carcinoma of uterine cervix: A cause of pulmonary embolism

Han, Gwan Hee; Kwon, Do Youn; Ulak, Roshani; Ki, Kyung‐Do; Lee, Jongmin; Lee, Seonkyung

doi:10.5468/ogs.2017.60.1.129

Cited by 14 publications

(13 citation statements)

References 10 publications

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“…Clinical features including rapid onset of symptoms with PH and acute right heart failure would be indistinguishable. Tumour macroembolism is reported in cases of breast cancer [59], hepatocellular carcinoma [60], choriocarcinoma [10,55,61,62] and, less often, subdiaphragmatic cancers including cervical carcinoma [63]. PTE/PTTM may of course coexist [4,60].…”

Section: Tumour Macroembolismmentioning

confidence: 99%

“…PTE/PTTM may of course coexist [4,60]. These reflect the tumours that more commonly spread to the heart and great vessels (renal, lung, breast, oesophagus, malignant lymphoma, leukaemia and malignant melanoma), through the vena cava (including invasive renal tumours that may fragment), arterial circulation, retrograde lymph node spread, or directly from adjacent viscera [63]. Overall metastatic cardiac cancer rates are low at 1.2% [64], and thought to relate to cardiac movement thereby rapid blood and lymphatic flow away from the heart [63].…”

Section: Tumour Macroembolismmentioning

confidence: 99%

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Tumoral pulmonary hypertension

et al. 2019

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Tumoral pulmonary hypertension (PH) comprises a variety of subtypes in patients with a current or previous malignancy. Tumoral PH principally includes the tumour-related pulmonary microvascular conditions pulmonary tumour microembolism and pulmonary tumour thrombotic microangiopathy. These inter-related conditions are frequently found inpost mortemspecimens but are notoriously difficult to diagnoseante mortem. The outlook for patients remains extremely poor although there is some emerging evidence that pulmonary vasodilators and anti-inflammatory approaches may improve survival. Tumoral PH also includes pulmonary macroembolism and tumours that involve the proximal pulmonary vasculature, such as angiosarcoma; both may mimic pulmonary embolism and chronic thromboembolic PH. Finally, tumoral PH may develop in response to treatments of an underlying malignancy. There is increasing interest in pulmonary arterial hypertension induced by tyrosine kinase inhibitors, such as dasatanib. In addition, radiotherapy and chemotherapeutic agents such as mitomycin-C can cause pulmonary veno-occlusive disease. Tumoral PH should be considered in any patient presenting with unexplained PH, especially if it is poorly responsive to standard approaches or there is a history of malignancy. This article will describe subtypes of tumoral PH, their pathophysiology, investigation and management options in turn.

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Section: Tumour Macroembolismmentioning

confidence: 99%

Section: Tumour Macroembolismmentioning

confidence: 99%

Tumoral pulmonary hypertension

et al. 2019

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“…To the best of our knowledge, only 20 cases of cardiac metastasis of uterine cervical cancer have been reported in the literature thus far. Of note, only three patients (including the present case) have been diagnosed with cancer and cardiac metastasis concurrently …”

Section: Commentsmentioning

confidence: 81%

“…In the present case, the cardiac metastatic tumor was larger than the primary cervical carcinoma. Owing to the short survival (<6 months) of patients with cardiac metastasis, diagnosis before death is unusual compared with benign cardiac tumors . The antemortem diagnosis of cardiac metastasis of uterine cervical cancer is much rarer.…”

Section: Commentsmentioning

confidence: 99%

Intracardiac metastasis from unknown uterine cervical cancer with severe thrombocytopenia

et al. 2019

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Introduction: Cardiac metastasis is relatively common in malignant neoplasms, such as lung cancers, breast cancers, melanomas, lymphomas, and leukemias. In contrast, cardiac metastasis of uterine cervical cancer, solitary metastasis to the heart, and tumors inducing severe thrombocytopenia are rare.Case Report: The present patient was a 52-year-old female who was diagnosed with a solitary cardiac tumor prior to uterine cervical cancer and presented with severe thrombocytopenia. Our case had two remarkable aspects: 1) successful treatment under the condition of severe thrombocytopenia in association with the presence of a cardiac tumor, and survival without recurrence of the carcinoma one year after surgery; and 2) a solitary cardiac metastatic tumor larger than the primary uterine cervix carcinoma.Comment: we report an extremely rare case of solitary cardiac metastasis of uterine cervical cancer, which wassuccessfully treated. One year after cardiac surgery, the patient is alive without recurrence of the carcinoma. K E Y W O R D S cardiac tumor, intracardiac metastasis, thrombocytopenia, uterine cervical cancer

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“…The most common symptoms attributable to cardiac metastasis are nonspecific and mimic other cardiac diseases such as myocardial ischemia, heart failure, or cardiac injury related to chemotherapy or radiation therapy. These symptoms include dyspnea, chest pain, palpitations, lower extremity edema, and new-onset atrial fibrillation [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Low-grade endometrial stromal sarcoma with inferior vena cava tumor thrombus and intracardiac extension

Valdespino¹,

Ramón²,

Cordova³

et al. 2017

Gen Med Open

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The endometrial stromal sarcoma is a rare neoplasm of the uterine origin. Intracardiac metastasis form the low-grade endometrial stromal sarcoma is an extremely rare event. A case of a patient who underwent surgical resection of metastatic tumors of the low-grade endometrial stromal sarcoma in the right atrium is described in the present report. Cardiac malignancies account for less than 1% of cardiac surgery and around 0.1% of cardiac echo graphic studies. The presence of metastatic tumor to the heart usually indicates widespread metastases. Lung carcinomas are the most commonly encountered tumor followed by breast and pancreas cancer and melanoma.We show the case report of a woman with endometrial stromal sarcoma who developed a right heart failure, lower extremity edema, dyspnea and orthopnea after the initial step of comprehensive surgery and radiotherapy. Heart metastases was diagnosed by computed tomography and echocardiophy after a palliative metastasectomy; the patient received chemotherapy and hormotherapy without showing response, re-developing a heart metastasic tumor. Tumoral activity was the cause of her death.It is very difficult to standardize care procedures for these patients due to the rarity of this condition. However, it is possible that aggressive therapy (surgery plus radiotherapy and chemotherapy) may lengthen patients survival and improve life quality.

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Right ventricular metastatic tumor from a primary carcinoma of uterine cervix: A cause of pulmonary embolism

Cited by 14 publications

References 10 publications

Tumoral pulmonary hypertension

Tumoral pulmonary hypertension

Intracardiac metastasis from unknown uterine cervical cancer with severe thrombocytopenia

Low-grade endometrial stromal sarcoma with inferior vena cava tumor thrombus and intracardiac extension

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