Right ventricular dysfunction and risk of heart failure and mortality after myocardial infarction

Zornoff, Leonardo A. M.; Skali, Hicham; Pfeffer, Marc A.; Sutton, Martin St. John; Rouleau, Jean L.; Lamas, Gervasio A.; Plappert, Ted; Rouleau, Jacques R.; Moyé, Lemuel A.; Lewis, Sandra; Braunwald, Eugene; Solomon, Scott D.; investigators, SAVE substudy

doi:10.1016/s0735-1097(02)01804-1

Cited by 400 publications

(333 citation statements)

References 28 publications

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“…Substudy from the SAVE study in subjects after MI with impaired LV function showed that RV dysfunction was an independent risk factor of total mortality, cardiovascular mortality and occurrence of CHF. Each 5% reduction in the RVFAC resulted in 16% increased odds of cardiovascular mortality [9]. Other studies showed, that in patients with advanced CHF and LV ejection fraction (LVEF) < 40% prognosis strongly depends on RV function.…”

Section: Right Ventricular Function In Chronic Heart Failurementioning

confidence: 99%

The right ventricle in patients with chronic heart failure and atrial fibrillation

Majos

Dąbrowski²,

Szwed³

2013

Cardiol J

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Section: Right Ventricular Function In Chronic Heart Failurementioning

confidence: 99%

The right ventricle in patients with chronic heart failure and atrial fibrillation

Majos

Dąbrowski²,

Szwed³

2013

Cardiol J

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“…Recent studies have reported that RV function has prognostic implications in several cardiovascular diseases (50)(51)(52). Of all cases of TCC, 13% involve RV (51).…”

Section: Right Ventricular Functionmentioning

confidence: 99%

Role of echocardiography for takotsubo cardiomyopathy: clinical and prognostic implications

Izumo¹,

Akashi²

2018

Cardiovasc. Diagn. Ther.

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Takotsubo cardiomyopathy (TTC) is newly-described secondary cardiomyopathy characterized by transient left ventricular (LV) dysfunction, which is increasingly recognized in the field of cardiology.TTC occurs in approximately 2% of the patients with acute coronary syndrome. Its onset is rare; however, its specific features play a crucial role in diagnosing the chest pain in clinical practice. TTC has generally favorable outcome with rapid recovery of LV function; however, an increasing evidence suggests that it should be regarded as a more serious acute cardiac disorder with a variety of complications. Owing to its widespread availability, even in emergency settings, transthoracic echocardiography plays a key role in the diagnostic assessment of TTC and contributes to an increased number of disease detection and incidence reports in contemporary clinical practice. This review focuses on the role of echocardiography in understanding the clinical prognostic implications in patients with TTC.

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“…In a state of right ventricular pressure overload this ventricular interdependence may be ascribed to pathologic septal motion, decreased LV preload or other unknown factors (Dittrich et al, 1989;Mizushige et al, 1989;Yu et al, 1996). RV function is an independent predictor of mortality and the development of heart failure (HF) in patients with known LV dysfunction (Zornoff et al, 2002) and right ventricular involvement during acute inferior myocardial infarction is a strong, independent predictor of major complications and in-hospital mortality (Zehender et al, 1993). Finally, 5-10% of patients with advanced chronic obstructive pulmonary disease (COPD) may suffer from severe pulmonary hypertension and present with a progressively downhill clinical course because of right heart failure added to the ventilatory handicap (Naeije, 2005).…”

Section: Introductionmentioning

confidence: 99%

Characterization of a rat model of right-sided heart failure induced by pulmonary trunk banding

Schou

Peters

Kim

et al. 2007

Journal of Experimental Animal Science

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Animal models of disease are essential for cardiovascular research. However, animal models of right-sided heart failure are few and remain poorly characterized. The aim with this study was to establish a rat model of right-sided heart failure (HF) using pulmonary trunk banding (PTB) and subsequently to characterize the systemic and cardiac changes in this model, including protein expression of SERCA2 and a-sarcomeric actin. Rats underwent banding or sham operation. To evaluate the development of HF over time three groups were included in this study. They were killed 2-3, 5-7 or 16-17 weeks after operation, respectively. PTB rats showed marked hypertrophy of the right ventricle (RV). Catheterization of the RV showed a three-to four-fold increase in right ventricular systolic and diastolic pressures as well as increased dP/dT max and dP/dT min. Plasma analyses revealed increased liver enzymes in most PTB groups and post mortem examination revealed congestion of the liver as well as formation of ascites and hydrothorax in many PTB rats. Immunoblotting of the RV revealed no changes in SERCA2 or a-sarcomeric actin. In conclusion, PTB was an effective method to induce right-sided HF. The presence of HF was confirmed by severe signs of backward failure in conjunction with markedly elevated RV pressures and reduced RV ejection fraction (EF). r

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Right ventricular dysfunction and risk of heart failure and mortality after myocardial infarction

Abstract: Right ventricular function is an independent predictor of death and the development of HF in patients with LV dysfunction after MI.

Cited by 400 publications

References 28 publications

The right ventricle in patients with chronic heart failure and atrial fibrillation

The right ventricle in patients with chronic heart failure and atrial fibrillation

Role of echocardiography for takotsubo cardiomyopathy: clinical and prognostic implications

Characterization of a rat model of right-sided heart failure induced by pulmonary trunk banding

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