Right ventricular diastolic performance: Compliance characteristics with focus on pulmonary hypertension, right ventricular hypertrophy, and calcium channel blockade

Ferlinz, Jack

doi:10.1002/(sici)1097-0304(199802)43:2<206::aid-ccd22>3.0.co;2-k

Cited by 3 publications

(3 citation statements)

References 316 publications

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“… 40 – 42 Initial myocardial hypertrophy is related to adaptation to the pressure overload, and progressive increases in afterload result in ventricular remodeling associated with chamber dilation, eventually decompensation and development of right-sided heart failure. 7 , 8 , 43 , 44 RV hypertrophy is associated with decreased RV compliance, increased end-diastolic pressure, and subsequent RV diastolic dysfunction; furthermore, diastolic relaxation impairment is highly correlated with end-diastolic calcium levels, possibly due to the reduced production of cAMP; nonetheless, systolic function may remain relatively normal for long periods of chronic afterload elevation before the development of overt systolic failure. 19 , 43 , 44 Echocardiography is a useful method for evaluating right-sided heart morphology and function in rats with MCT-induced PH and has been shown to be accurate for assessing cardiac function.…”

Section: Discussionmentioning

confidence: 99%

“… 7 , 8 , 43 , 44 RV hypertrophy is associated with decreased RV compliance, increased end-diastolic pressure, and subsequent RV diastolic dysfunction; furthermore, diastolic relaxation impairment is highly correlated with end-diastolic calcium levels, possibly due to the reduced production of cAMP; nonetheless, systolic function may remain relatively normal for long periods of chronic afterload elevation before the development of overt systolic failure. 19 , 43 , 44 Echocardiography is a useful method for evaluating right-sided heart morphology and function in rats with MCT-induced PH and has been shown to be accurate for assessing cardiac function. 40 , 45 – 47 The echocardiographic parameters acquired from the M group were similar to those obtained by Boissiere et al and Hardziyenka et al in Wistar rats with MCT-induced PH.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension

Nakata

Tanaka

Yoshiyuki

et al. 2015

Journal of Cardiovascular Pharmacology

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Abstract:This study was designed to assess the progression of pulmonary arterial hypertension (PAH) and the effectiveness of therapy using recently investigated echocardiographic parameters. PAH is characterized by the progressive elevation of pulmonary artery pressure and right ventricular hypertrophy and dysfunction, which ultimately results in right-sided heart failure and death. Echocardiography results and invasive measurements of right and left ventricular systolic pressures were compared after 3-week administrations of sildenafil (S group), pimobendan (P group), nicorandil (N group), and their combinations (SP and SPN groups) in male rats with monocrotaline (MCT)-induced pulmonary hypertension (M group) and without this condition (C group). The groups that received pimobendan alone and in combinations (SP and SPN groups) showed improvement in their echocardiographic parameters of systolic function. A significant improvement of diastolic function was achieved in the SPN group. Invasive measurements showed the most significant decreases of right ventricular systolic pressure in the N and SPN groups, and the use of pimobendan resulted in a comparatively low risk of adverse hemodynamic effects (left ventricular systolic pressure). Although our results suggested the attenuation of PAH severity in all treatment groups, PAH could not be reversed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension

Nakata

Tanaka

Yoshiyuki

et al. 2015

Journal of Cardiovascular Pharmacology

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“…Endothelial dysfunction, including an increase in endothelial permeability and apoptosis, is associated with and likely promotes PH 2, 4, 5 . With time, the increase in pulmonary vascular resistance and pressure results in right ventricular (RV) hypertrophy, dilatation, and dysfunction 4, 6 . Cardiopulmonary disorders associated with elevated pulmonary artery pressures are one of the leading cause of RV hypertrophy and failure 7 .…”

Section: Introductionmentioning

confidence: 99%

Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling

Cheng

Dong

Panchatcharam

et al. 2012

ATVB

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Objective Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D (lysoPLD) enzyme autotaxin that is present at ≥ 100 nM in plasma. Local administration of LPA promotes systemic arterial remodeling in rodents. To determine if LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism. Methods and Results Enpp2+/− mice, heterozygous for the autotaxin-encoding gene, that have reduced expression of autotaxin/lysoPLD and ~half normal plasma LPA, were hyper-responsive to hypoxia-induced vasoconstriction and remodeling, as evidenced by the development of higher right ventricular (RV) systolic pressure, greater decline in peak flow velocity across the pulmonary valve, and a higher percentage of muscularized arterioles. Mice lacking LPA1 and LPA2, two LPA receptors abundantly expressed in the vasculature, also had enhanced hypoxia-induced pulmonary remodeling. With age, Lpar1−/−2−/− mice spontaneously developed elevated RV systolic pressure and RV hypertrophy that was not observed in Lpar1−/− mice or Lpar2−/− mice. Expression of endothelin-1, a potent vasoconstrictor, was elevated in lungs of Lpar1−/−2−/− mice, and expression of ETB receptor, which promotes vasodilation and clears endothelin, was reduced in Enpp2+/− and Lpar1−/−2−/− mice. Conclusions Our findings indicate that LPA may negatively regulate pulmonary vascular pressure through LPA1 and LPA2 receptors, and that in the absence of LPA signaling, upregulation in the endothelin system favors remodeling.

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Doppler Echocardiographic Evaluation of Right Ventricular Diastolic Function in Hypertrophic Cardiomyopathy

Efthimiadis

Parharidis

Karvounis

et al. 2002

European Journal of Echocardiography

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Right ventricular diastolic performance: Compliance characteristics with focus on pulmonary hypertension, right ventricular hypertrophy, and calcium channel blockade

Cited by 3 publications

References 316 publications

Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension

Effects of Single Drug and Combined Short-term Administration of Sildenafil, Pimobendan, and Nicorandil on Right Ventricular Function in Rats With Monocrotaline-induced Pulmonary Hypertension

Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature From Hypoxia-Induced Remodeling

Doppler Echocardiographic Evaluation of Right Ventricular Diastolic Function in Hypertrophic Cardiomyopathy

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