Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography

Kachenoura, Nadjia; Bollache, Emilie; Soulat, Gilles; Clément-Guinaudeau, Stéphanie; Ashrafpoor, Golmehr; Perdrix, Ludivine; Diebold, B.; Ladouceur, Magalie; Mousseaux, Élie

doi:10.1007/s10554-020-02040-y

Cited by 4 publications

(7 citation statements)

References 33 publications

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“…In contrast to results from left ventricle analysis, we often observed a RV peak filling rate lower than the peak filling rate due to atrial contraction, with an overall Ef T /Af T ratio significantly lower in SSc patients than in controls. This finding reveals an impaired relaxation pattern as previously found in healthy elderly subjects 24 . Thus, our results confirm that RV diastolic dysfunction is often present in SSc patients, as previously shown by tissue Doppler imaging parameters 10,30,31 .…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, only one operator blinded to all other data measured diastolic functional indices on MRI in the present study. The reproducibility of RV diastolic function indices with the PC‐MRI sequence used in this study, however, is high (coefficient of variation ≤ 21% and intraclass correlation coefficient ≥ 0.75) and we have also showed that such indices provide higher age‐related correlations than TTE indices recorded on the same day 24 . Another limitation of this pilot study is the lack of MRI T1 mapping‐derived interstitial fibrosis assessment, which is increased in the LV myocardium of SSc patients 33 …”

Section: Limitationsmentioning

confidence: 58%

“…Blood flow and myocardial velocity PC-MRI data were analyzed by an operator with 4 years of experience (LAC) blind to clinical data using the CardFlow software (Sorbonne Université, U1146 Inserm). 19,23,24 Briefly, semiautomated delineation of transmitral and transtricuspid flow from PC transvalvular velocity images throughout the cardiac cycle provided time-resolved mean velocity and flow rate curves (Fig. 1).…”

Section: Mri Image Analysismentioning

confidence: 99%

“…However, recent studies endorse the use of phasecontrast MRI (PC-MRI) to assess diastolic function based on transmitral and tricuspid inflow, and myocardial wall motion analysis at the level of the valve annulus. [19][20][21][22][23][24] Therefore, the aim of this study was to assess LV and RV diastolic function in SSc patients using PC-MRI and to explore the association between SSc disease-related characteristics with remodeling and with the presence of scar fibrosis replacement.…”

mentioning

confidence: 99%

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Diastolic Function Assessment of Left and Right Ventricles by MRI in Systemic Sclerosis Patients

Mousseaux

Agoşton-Coldea

Marjanovic

et al. 2022

Magnetic Resonance Imaging

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Background Heart involvement is frequent although often clinically silent in systemic sclerosis (SSc) patients. Early identification of cardiac involvement can be improved by noninvasive methods such as MRI, in addition to transthoracic echocardiography (TTE). Purpose To assess the ability of phase‐contrast (PC)‐MRI to detect subclinical left (LV) and right (RV) ventricular diastolic dysfunction in SSc patients. Study Type Prospective. Population Thirty‐five consecutive SSc patients (49 ± 14 years) and 35 sex‐ and age‐matched healthy controls (48.6 ± 13.5 years) who underwent TTE and MRI in the same week. Field Strength/Sequence 5 T/PC‐MRI using a breath‐hold velocity‐encoded gradient echo sequence. Assessment LV TTE (E/E′) and LV and RV PC‐MRI indices of diastolic function (LV early and late transmitral [EM, EfM, AM, AfM] and RV transtricuspid [ET, EfT, AT, AfT] peak filling flow velocities and flow rates, as well as LV [EM'] and RV [ET'] peak longitudinal myocardial velocities during diastole) were measured. Statistical Tests Two‐tailed t‐test, Wilcoxon test, or Fischer test for comparison of variables between SSc and healthy control groups; sensitivity, specificity, receiver‐operating‐characteristic (ROC) area under the curve (AUC) to assess discriminative ability of variables. A P‐value <0.05 was considered statistically significant. Results TTE LV E/E′ and MRI EM/EM' and ET/ET' were significantly higher in SSc patients than in controls (8.27 ± 1.25 vs. 6.70 ± 1.66; 9.43 ± 2.7 vs. 6.51 ± 1.50; 6.51 [4.70–10.40] vs. 4.13 [3.22–5.75], respectively) and separated SSc patients and healthy controls with good sensitivity (68%, 71%, and 80%), specificity (85%, 94%, and 62%), and AUC (0.787, 0.807, and 0.765). LV EfM was significantly higher in SSc patients than in controls (347.1 ± 113.7 vs. 284.7 ± 94.6) as RVAfT (277 [231–355] vs. 220 [154–253] mL/sec) with impaired relaxation pattern (EfT/AfT, 0.95 [0.87–1.21] vs. 1.12 [0.93–1.47]). Data Conclusion MRI was able to detect LV and RV diastolic dysfunction in SSc patients with good accuracy in the absence of LV systolic dysfunction at echocardiography. Use of MRI can allow to better assess the early impact of myocardial fibrosis related to SSc. Level of Evidence 1 Technical Efficacy Stage 2

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Section: Discussionsupporting

confidence: 92%

Section: Limitationsmentioning

confidence: 58%

Section: Mri Image Analysismentioning

confidence: 99%

mentioning

confidence: 99%

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Diastolic Function Assessment of Left and Right Ventricles by MRI in Systemic Sclerosis Patients

Mousseaux

Agoşton-Coldea

Marjanovic

et al. 2022

Magnetic Resonance Imaging

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“…Similar to observations in the LV, studies have demonstrated decreased RV systolic function, decreased early RV filling during diastole, and lower diastolic velocities in the RV associated with aging (Klein et al, 1999;Henein et al, 2014;Kachenoura et al, 2020). Additionally, the RV wall thickness increases with age.…”

Section: In Vivo Function Of the Healthy Geriatric Rvsupporting

confidence: 59%

Physiology of the Right Ventricle Across the Lifespan

Woulfe

Walker

2021

Front. Physiol.

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The most common cause of heart failure in the United States is ischemic left heart disease; accordingly, a vast amount of work has been done to elucidate the molecular mechanisms underlying pathologies of the left ventricle (LV) as a general model of heart failure. Until recently, little attention has been paid to the right ventricle (RV) and it has commonly been thought that the mechanical and biochemical properties of the RV are similar to those of the LV. However, therapies used to treat LV failure often fail to improve ventricular function in RV failure underscoring, the need to better understand the unique physiologic and pathophysiologic properties of the RV. Importantly, hemodynamic stresses (such as pressure overload) often underlie right heart failure further differentiating RV failure as unique from LV failure. There are significant structural, mechanical, and biochemical properties distinctive to the RV that influences its function and it is likely that adaptations of the RV occur uniquely across the lifespan. We have previously reviewed the adult RV compared to the LV but there is little known about differences in the pediatric or aged RV. Accordingly, in this mini-review, we will examine the subtle distinctions between the RV and LV that are maintained physiologically across the lifespan and will highlight significant knowledge gaps in our understanding of pediatric and aging RV. Consideration of how RV function is altered in different disease states in an age-specific manner may enable us to define RV function in health and importantly, in response to pathology.

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Assessment of right ventricular diastolic function in pediatric patients with repaired tetralogy of Fallot by cardiovascular magnetic resonance and echocardiography

Ouyang,

Leng,

Chen

et al. 2024

Eur Radiol

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Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography

Cited by 4 publications

References 33 publications

Diastolic Function Assessment of Left and Right Ventricles by MRI in Systemic Sclerosis Patients

Diastolic Function Assessment of Left and Right Ventricles by MRI in Systemic Sclerosis Patients

Physiology of the Right Ventricle Across the Lifespan

Assessment of right ventricular diastolic function in pediatric patients with repaired tetralogy of Fallot by cardiovascular magnetic resonance and echocardiography

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