Right Ventricle to Pulmonary Artery Conduit With Tricuspid Expanded Polytetrafluoroethylene Valves

Kobayashi, Kei; Shinkawa, Takeshi; Yamagishi, Masaaki; Saito, Satoshi; Nakayama, Yuki; Hoki, Ryogo; Yoshida, Hisashi; Niinami, Hiroshi

doi:10.1016/j.athoracsur.2020.06.119

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…However, Mery et al [ 13 ] reported that Contegra, particularly in younger patients, was associated with a higher incidence of distal conduit stenosis and early conduit insufficiency. Homemade PTFE valved conduits began to be used in earnest by Japanese groups and are a good alternative to RV-PA conduits, with a low risk of reoperation or reintervention [ 11 , 18 - 21 ]. Our center adopted a homemade tricuspid PTFE-valved conduit that was made using the technique introduced by Kim et al [ 22 ] in 2013.…”

Section: Discussionmentioning

confidence: 99%

Outcomes after Biventricular Repair Using a Conduit between the Right Ventricle and Pulmonary Artery in Infancy

Jang,

Kim,

Choi

et al. 2024

J Chest Surg

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Background This study investigated the outcomes of biventricular repair using right ventricle to pulmonary artery (RV-PA) conduit placement in patients aged <1 year. Methods Patients aged <1 year who underwent biventricular repair using an RV-PA conduit between 2011 and 2020 were included in this study. The outcomes of interest were death from any cause, conduit reintervention, and conduit dysfunction (peak velocity of ≥3.5 m/sec or moderate or severe regurgitation). Results In total, 141 patients were enrolled. The median age at initial conduit implantation was 6 months. The median conduit diameter z-score was 1.3. The overall 5-year survival rate was 89.6%. In the multivariable analysis, younger age (p=0.006) and longer cardiopulmonary bypass time (p=0.001) were risk factors for overall mortality. During follow-up, 61 patients required conduit reintervention, and conduit dysfunction occurred in 68 patients. The 5-year freedom from conduit reintervention and dysfunction rates were 52.9% and 45.9%, respectively. In the multivariable analysis, a smaller conduit z-score (p<0.001) was a shared risk factor for both conduit reintervention and dysfunction. Analysis of variance demonstrated a nonlinear relationship between the conduit z-score and conduit reintervention or dysfunction. The hazard ratio was lowest in patients with a conduit z-score of 1.3 for reintervention and a conduit z-score of 1.4 for dysfunction. Conclusion RV-PA conduit placement can be safely performed in infants. A significant number of patients required conduit reintervention and had conduit dysfunction. A slightly oversized conduit with a z-score of 1.3 may reduce the risk of conduit reintervention or dysfunction.

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Section: Discussionmentioning

confidence: 99%

Outcomes after Biventricular Repair Using a Conduit between the Right Ventricle and Pulmonary Artery in Infancy

Jang,

Kim,

Choi

et al. 2024

J Chest Surg

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“…PTFE valved conduits show excellent hemodynamic performance in preclinical in vitro and in vivo experiments ( 95 – 97 ). The results of mid-term clinical trials showed less need for further intervention and severe valvular dysfunction ( 98 , 99 ), especially in valvular regurgitation ( 100 ). And the failure incidence of this conduit is lower than that of autologous pericardial valved conduit operation ( 101 ).…”

Section: Xenograft Valved Conduits and Other Possible Alternativesmentioning

confidence: 99%

Application of Homograft Valved Conduit in Cardiac Surgery

Huyan

Chang

Song

2021

Front. Cardiovasc. Med.

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Valved conduits often correct the blood flow of congenital heart disease by connecting the right ventricle to the pulmonary artery (RV-PA). The homograft valved conduit was invented in the 1960s, but its wide application is limited due to the lack of effective sterilization and preservation methods. Modern cryopreservation prolongs the preservation time of homograft valved conduit, which makes it become the most important treatment at present, and is widely used in Ross and other operations. However, homograft valved conduit has limited biocompatibility and durability and lacks any additional growth capacity. Therefore, decellularized valved conduit has been proposed as an effective improved method, which can reduce immune response and calcification, and has potential growth ability. In addition, as a possible substitute, commercial xenograft valved conduit has certain advantages in clinical application, and tissue engineering artificial valved conduit needs to be further studied.

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Handmade tri-leaflet ePTFE conduits versus homografts for right ventricular outflow tract reconstruction

Wang

Mao

et al. 2022

World J Pediatr

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Right Ventricle to Pulmonary Artery Conduit With Tricuspid Expanded Polytetrafluoroethylene Valves

Cited by 4 publications

References 17 publications

Outcomes after Biventricular Repair Using a Conduit between the Right Ventricle and Pulmonary Artery in Infancy

Outcomes after Biventricular Repair Using a Conduit between the Right Ventricle and Pulmonary Artery in Infancy

Application of Homograft Valved Conduit in Cardiac Surgery

Handmade tri-leaflet ePTFE conduits versus homografts for right ventricular outflow tract reconstruction

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