Right Latissimus Dorsi Cardiomyoplasty Improves Left Ventricular Energetics

Aklog, Lishan; Chen, Frederick Y.; deGuzman, Brian J.; Murphy, Michael P.; Smith, Wendel J.; Laurence, Rita G.; Appleyard, Robert F.; Cohn, Lawrence H.

doi:10.1016/s0003-4975(97)00580-8

The Annals of Thoracic Surgery

1997

DOI: 10.1016/s0003-4975(97)00580-8

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Right Latissimus Dorsi Cardiomyoplasty Improves Left Ventricular Energetics

Lishan Aklog

Frederick Y. Chen

Brian J. deGuzman

et al.

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Cited by 3 publications

(2 citation statements)

References 22 publications

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“…1,2 It is currently being evaluated as a therapeutic option for patients with congestive heart failure. [3][4][5][6][7][8] In the early clinical trials, despite significant subjective clinical improvements, objective benefits were inconsistently noted. [3][4][5] Most previous studies focused on improvement of the heart's systolic function measured as ejection fraction, systolic pressure, stroke volume, cardiac output, or the load-independent contractility index, E max .…”

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confidence: 99%

“…[3][4][5] Most previous studies focused on improvement of the heart's systolic function measured as ejection fraction, systolic pressure, stroke volume, cardiac output, or the load-independent contractility index, E max . 7,9,10 When patients showed significant improvement of their symptoms without improvement of objective parameters, it was unclear whether it was attributable to a placebo effect or other factors not evaluated. The efficiency of the energy transfer from the total mechanical energy to external work in each beat could be an important factor in improving a patient's symptoms.…”

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confidence: 99%

See 1 more Smart Citation

Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship

Kawaguchi¹,

Huang²,

Yuasa³

et al. 1998

The Journal of Thoracic and Cardiovascular Surgery

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confidence: 99%

mentioning

confidence: 99%

Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship

Kawaguchi¹,

Huang²,

Yuasa³

et al. 1998

The Journal of Thoracic and Cardiovascular Surgery

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Myocardial Oxygen Consumption Is Affected by Dynamic Cardiomyoplasty in Dogs with Adriamycin-Induced Cardiomyopathy

Monnet

Orton

1998

J Cardiac Surgery

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The purpose of the study was to investigate a possible myocardial sparing effect by dynamic cardiomyoplasty. We directly measured cardiac work and myocardial oxygen consumption after dynamic cardiomyopathy in dogs with adriamycin-induced cardiomyopathy. Ten dogs with cardiomyopathy induced by 4 weekly intracoronary infusions of adriamycin were studied. Five dogs underwent right latissimus dorsi cardiomyoplasty with progressive myostimulation, and five served as controls. Right heart and coronary sinus catheterizations were performed at 0, 10, and 15 weeks. Four and two dogs, respectively, the cardiomyoplasty and the control group, survived until 15 weeks. Cardiac work was not different between the control and the cardiomyoplasty groups (p = 0.42). Myocardial oxygen consumption was less in the cardiomyoplasty group (185.70 +/- 37.22; 165.75 +/- 25.86; 161.40 +/- 54.14 J/min at 0, 10, and 15 weeks, respectively) compared to the control group (147.80 +/- 70.99; 275.00 +/- 103.24; 263.50 +/- 52.75 J/min at 0, 10, and 15 weeks, respectively, p = 0.019). Mechanical cardiac efficiency was not meaningfully different between the cardiomyoplasty group (16.08% +/- 5.39%; 20.51% +/- 5.89%; 20.67% +/- 11.98% at 0, 10, and 15 weeks, respectively) compared to the control group (15.29% +/- 8.06%; 9.40% +/- 1.22%; 13.40% +/- 2.29% at 0, 10, and 15 weeks, respectively, p = 0.093). Acute changes of the cardiosynchronization ratio (2:1, 1:1, OFF) did not affect myocardial oxygen consumption or cardiac work within the cardiomyoplasty group. Dynamic cardiomyoplasty reduced myocardial oxygen consumption in dogs with adriamycin-induced cardiomyopathy.

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Adynamic Cardiomyoplasty: Effect on Cardiac Efficiency and Contractile Reserve in Dogs with Adriamycin-Induced Cardiomyopathy

Monnet

2008

Journal of Cardiac Surgery

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ASTRACT The girdling effect of the skeletal muscle wrap seems t o b e t h e primary mechanism of action of cardiomyoplasty. It is associated with a myocardial sparing effect. Myocardial sparing effect has been shown with an active muscle wrap or an active muscle wrap acutely turned "OFF". The purpose of t h e study was t o evaluate the effect of a passive skelet a l muscle wrap on cardiac energetics parameters and contractile reserve in a canine model of cardiomyopathy. Six dogs with adriamycin-induced cardiomyopathy were studied. Three dogs underwent right latissimus dorsi adynamic cardiomyoplasty and 3 served as controls. Cardiac and coronary sinus catheterizations were performed a t 0 and 6 weeks. A dobutamine stress test was performed at 6 weeks. Myocardial oxygen consumption was n o t reduced in the cardiomyoplasty group (139.20 f 86.90 Joules/min) compared t o the control group ~

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Right Latissimus Dorsi Cardiomyoplasty Improves Left Ventricular Energetics

Cited by 3 publications

References 22 publications

Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship

Improved efficiency of energy transfer to external work in chronic cardiomyoplasty based on the pressure-volume relationship

Myocardial Oxygen Consumption Is Affected by Dynamic Cardiomyoplasty in Dogs with Adriamycin-Induced Cardiomyopathy

Adynamic Cardiomyoplasty: Effect on Cardiac Efficiency and Contractile Reserve in Dogs with Adriamycin-Induced Cardiomyopathy

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