Right‐lateralization of N2‐amplitudes in depressive adolescents: an emotional go/no‐go study

Trinkl, Monika; Greimel, Ellen; Bartling, Jürgen; Grünewald, Barbara; Schulte‐Körne, Gerd; Großheinrich, Nicola

doi:10.1111/jcpp.12282

Cited by 18 publications

(10 citation statements)

References 67 publications

(92 reference statements)

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“…While the left hemisphere is thought to actively process positive emotions or approach-related behavior, the right is thought to process negative emotions or withdrawal behav-ior. 22 Our data indicate a hemispheric asymmetry of cognitive dysfunction in subjects with GAD. Interestingly, GAD has been related to increased right-hemispherical activation, especially in emotional processing.…”

Section: Discussionmentioning

confidence: 54%

Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

Yang¹,

Zhang²,

Zhu³

et al. 2015

NDT

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BackgroundCognitive function in anxiety disorders has been the subject of limited investigation, especially in generalized anxiety disorder (GAD). The purpose of this study was to investigate the cognitive function in subjects with GAD using mismatch-triggered negativity N270.MethodsFifteen medication-free patients with a DSM-IV diagnosis of GAD, and 15 well-matched healthy controls performed a dual-feature delayed matching task while event-related potentials were recorded from their scalp.ResultsThe GAD group was characterized by the decreased N270 amplitude in the left hemisphere. The smaller N270 amplitude was associated with greater symptoms of anxiety and depression.ConclusionSince N270 is thought to index cognitive function in different domains, including attention and memory, our results suggest that individuals with GAD have an impaired cognitive function, particularly in selective attention and working memory. These cognitive deficits may have clinical significance in subjects with GAD and should be considered in treatment planning.

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Section: Discussionmentioning

confidence: 54%

Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

Yang¹,

Zhang²,

Zhu³

et al. 2015

NDT

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“…The response time (time until selection of one category) in ms, the selected category (correct responses), and the rating of emotional intensity (0–100; in case happy or sad were selected as category) were recorded. Third, patients were asked to complete an emotional Go/NoGo-task designed in accordance with a previous study (Trinkl et al, 2015). Following an instruction screen, patients were asked to press the left mouse key whenever a target stimulus was displayed (go-cue) and inhibit the response whenever a non-target stimulus was displayed (no-go-cue).…”

Section: Methodsmentioning

confidence: 99%

Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression

et al. 2019

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Background Transcutaneous vagus nerve stimulation (tVNS) is a promising therapeutic option for major depressive disorder (MDD) in adults. Alternative third-line treatments for MDD in adolescents are scarce. Here we aimed to assess the effects of acute tVNS on emotion recognition in adolescents with MDD. Methods Adolescents (14–17 years) with MDD (n = 33) and non-depressed controls (n = 30) received tVNS or sham-stimulation in a cross-sectional, case–control, within-subject cross-randomized controlled trial, while performing different tasks assessing emotion recognition. Correct responses, response times, and errors of omission and commission on three different computerized emotion recognition tasks were assessed as main outcomes. Simultaneous recordings of electrocardiography and electro dermal activity, as well as sampling of saliva for the determination of α-amylase, were used to quantify the effects on autonomic nervous system function. Results tVNS had no effect on the recognition of gradually or static expressed emotions but altered response inhibition on the emotional Go/NoGo-task. Specifically, tVNS increased the likelihood of omitting a response toward sad target-stimuli in adolescents with MDD, while decreasing errors (independent of the target emotion) in controls. Effects of acute tVNS on autonomic nervous system function were found in non-depressed controls only. Conclusions Acute tVNS alters the recognition of briefly presented facial expressions of negative valence in adolescents with MDD while generally increasing emotion recognition in controls. tVNS seems to specifically alter early visual processing of stimuli of negative emotional valence in MDD. These findings suggest a potential therapeutic benefit of tVNS in adolescent MDD that requires further evaluation within clinical trials.

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“…Additionally, an avoidance bias away from negative stimuli was also found repeatedly in offspring of depressive mothers (e.g., Boyd et al, 2006) and in juvenile MDD (Harrison and Gibb, 2015), which is probably based on a different neurocognitive mechanism in contrast to adult MDD. As one possible mechanism, among others (Gibb et al, 2016), enhanced reward seeking in adolescence, which is discussed to overshadow adolescent MDD (Trinkl et al, 2015), may help adolescents to disengage their attention away from negative stimuli. In the present experiment, we argue that we were not able to observe any protective bias to avoid sadness, as a sad mood was voluntarily induced and experimentally desired.…”

Section: Discussionmentioning

confidence: 99%

Looking While Unhappy: A Mood-Congruent Attention Bias Toward Sad Adult Faces in Children

et al. 2018

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A negative mood-congruent attention bias has been consistently observed, for example, in clinical studies on major depression. This bias is assumed to be dysfunctional in that it supports maintaining a sad mood, whereas a potentially adaptive role has largely been neglected. Previous experiments involving sad mood induction techniques found a negative mood-congruent attention bias specifically for young individuals, explained by an adaptive need for information transfer in the service of mood regulation. In the present study we investigated the attentional bias in typically developing children (aged 6–12 years) when happy and sad moods were induced. Crucially, we manipulated the age (adult vs. child) of the displayed pairs of facial expressions depicting sadness, anger, fear and happiness. The results indicate that sad children indeed exhibited a mood specific attention bias toward sad facial expressions. Additionally, this bias was more pronounced for adult faces. Results are discussed in the context of an information gain which should be stronger when looking at adult faces due to their more expansive life experience. These findings bear implications for both research methods and future interventions.

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Right‐lateralization of N2‐amplitudes in depressive adolescents: an emotional go/no‐go study

Cited by 18 publications

References 67 publications

Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

Effects of acute transcutaneous vagus nerve stimulation on emotion recognition in adolescent depression

Looking While Unhappy: A Mood-Congruent Attention Bias Toward Sad Adult Faces in Children

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