Right hemispatial neglect: Frequency and characterization following acute left hemisphere stroke

Kleinman, Jonathan T.; Newhart, Melissa; Davis, Cameron; Heidler‐Gary, Jennifer; Gottesman, Rebecca F.; Hillis, Argye E.

doi:10.1016/j.bandc.2006.10.005

Cited by 137 publications

(106 citation statements)

References 53 publications

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“…Limitations of our study include an inability to identify distinct types of perseveration, and no evaluation of left hemisphere strokes, although right spatial neglect occurs in a significant proportion of patients acutely following left hemisphere stroke [9,31]. Nys and colleagues (2006) found that perseveration occurred at similar rates following damage to each hemisphere, although right neglect increased central perseverations and left neglect increased right-sided perseverations [17].…”

Section: Discussionmentioning

confidence: 90%

“…Despite these concrete descriptions, both perseveration and neglect are heterogeneous disorders that can occur due to the breakdown of many cognitive processes. As a result, processing breakdowns manifest themselves distinctly in each test of neglect and also have distinct underlying neuroanatomical correlates that are described elsewhere [9][10][11]. Additionally, each deficit may serve to exacerbate other processing dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

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Disentangling the Neuroanatomical Correlates of Perseveration from Unilateral Spatial Neglect

Kleinman

DuBois

Newhart

et al. 2013

Behavioural Neurology

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Abstract. Perseverative behavior, manifest as re-cancelling or re-visiting targets, is distinct from spatial neglect. Perseveration is thought to reflect frontal or parietal lobe dysfunction, but the neuroanatomical correlates remain poorly defined and the interplay between neglect and perseveration is incompletely understood. We enrolled 87 consecutive patients with diffusion-weighted, perfusion-weighted imaging, and spatial neglect testing within 24 hours of right hemisphere ischemic stroke. The degrees of spatial neglect and perseveration were analyzed. Perseveration was apparent in 46% (40/87) of the patients; 28% (24/87) showed perseveration only; 18% (16/87) showed both perseveration and neglect; and 3% (3/87) showed neglect only. Perseverative behaviors occur in an inverted "U" shape: little neglect was associated with few perseverations; moderate neglect with high perseverations; and in severe neglect targets may not enter consciousness and perseverative responses decrease. Brodmann areas of dysfunction, and the caudate and putament, were assessed and volumetrically measured. In this study, the caudate and putamen were not associated with perseveration. After controlling for neglect, and volume of dysfunctional tissue, only Brodmann area 46 was associated with perseveration. Our results further support the notion that perseveration and neglect are distinct entities; while they often co-occur, acute dorsolateral prefrontal cortex ischemia is associated with perseveration specifically.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Disentangling the Neuroanatomical Correlates of Perseveration from Unilateral Spatial Neglect

Kleinman

DuBois

Newhart

et al. 2013

Behavioural Neurology

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“…Reports of hemineglect in patients with right cerebral injuries are very frequent [16][17][18] , although reports of hemineglect after left injuries can also be found 15,32 . A possible explanation to this fi nding would be the fact that individuals with dysphasia were included in the group of patients with left injuries.…”

Section: Discussionmentioning

confidence: 99%

Estudo comparativo entre a relação do hemisfério acometido no acidente vascular encefálico e a evolução funcional em indivíduos destros

Voos¹,

Valle²

2008

Rev. bras. fisioter.

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“…Hemispatial neglect can also occur following left brain damage, although it is reported less frequently (Kleinman et al, 2007). It may be the case that right hemispatial neglect is underdiagnosed or misdiagnosed, leading it to be studied less and to remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…It may be the case that right hemispatial neglect is underdiagnosed or misdiagnosed, leading it to be studied less and to remain poorly understood. Due to a lack of accurate data regarding the occurrence of right hemispatial neglect, Kleinman et al (2007) examined 47 patients following left hemisphere stroke. They found that 19 percent of patients presented with right hemispatial neglect and that neglect was better detected when several testing measures were used.…”

Section: Introductionmentioning

confidence: 99%

Upper and lower visual field differences in perceptual asymmetries

Elias

2011

Brain Research

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Neurologically normal individuals show a leftward spatial bias and tend to collide with objects on the right side more frequently than on the left. The upper visual field is associated with extrapersonal space, and mediated by the ventral stream through parvocellular projections.The lower visual field is associated with peripersonal space, and mediated by the dorsal stream through magnocellular projections. Upper and lower visual field differences have been observed in perceptual asymmetries but results have been mixed. Object-and space-based coordinates also both influence the leftward bias; however their relative contributions are unknown as similar spatial conditions are often collapsed across. More left-side collisions emerged on a route following task in the lower visual field and more right-side collisions were seen in the upper visual field (Thomas, Stuckel, Gutwin, & Elias, 2009). Left-handers made more right-side collisions in the central condition, whereas right-handers showed no bias. Leftward biases on the greyscales task were stronger in the lower visual field; however no distance-based differences were observed (Thomas & Elias, 2010). A stronger spatial bias was found on the greyscales task, whereas a stronger object-based bias was found on the object luminosity task (Thomas & Elias, in press). When individual spatial conditions were examined, the image chosen most often was always located in the lower field. Stimulus type and spatial location interacted to determine which coordinate type contributes more strongly to leftward biases. We also found that the leftward bias on the greyscales task was stronger in the lower visual field during prolonged presentation and in the upper visual field during brief presentation. A global motion task was created to preferentially engage magnocellular projections to the dorsal stream. Isoluminant red/green and blue/yellow colour tasks, which preferentially engage parvocellular projections to the ventral stream, were also created. Leftward biases were seen on the greyscales and motion tasks. On an isoluminant colour task, biases were significantly weakened, suggesting

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Right hemispatial neglect: Frequency and characterization following acute left hemisphere stroke

Cited by 137 publications

References 53 publications

Disentangling the Neuroanatomical Correlates of Perseveration from Unilateral Spatial Neglect

Disentangling the Neuroanatomical Correlates of Perseveration from Unilateral Spatial Neglect

Estudo comparativo entre a relação do hemisfério acometido no acidente vascular encefálico e a evolução funcional em indivíduos destros

Upper and lower visual field differences in perceptual asymmetries

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