Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Tadić, Marijana; Cuspidi, Cesare; Bombelli, Michele

doi:10.1111/jch.13186

Cited by 23 publications

(21 citation statements)

References 40 publications

(118 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We used joint modeling of multiple diseases to capture the effect of hypertension to investigate geographic variations in risk. 69 Recent studies reported that congestive heart failure, 70,71 atrial fibrillation, 72 and peripheral artery disease 73 are highly related to hypertension and could be used as proxies for hypertension. Although we do not have any variable directly reflecting hypertension, we could assume that we have controlled the effect of hypertension because we have included the above-mentioned 3 diseases as proxies for hypertension and added them to the final model (Supplemental Result 2, available online at http://www.mayoclinicproceedings.org).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Improvement in Mortality and End-Stage Renal Disease in Patients With Type 2 Diabetes After Acute Kidney Injury Who Are Prescribed Dipeptidyl Peptidase-4 Inhibitors

Chen

Lin

et al. 2018

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Objective: To focus on the potential beneficial effects of the pleiotropic effects of dipeptidyl peptidase-4 inhibitors (DPP4is) on attenuating progression of diabetic kidney disease in reducing the long-term effect of the acute kidney injury (AKI) to chronic kidney disease (CKD) transition. , were analyzed, and patients with diabetes weaning from dialysis-requiring AKI were identified. Cox proportional hazards models and inverse-weighted estimates of the probability of treatment were used to adjust for treatment selection bias. The outcomes were incident end-stage renal disease (ESRD) and mortality, major adverse cardiovascular events, and hospitalized heart failure. Results: Of a total of 6165 patients with diabetes weaning from dialysis-requiring AKI identified, 5635 (91.4%) patients were DPP4i nonusers and 530 (8.6%) patients were DPP4i users. Compared with DPP4i nonusers, DPP4i users had a lower risk of ESRD (hazard ratio, 0.81; 95% CI, 0.70-0.94; P¼.04) and allcause mortality (hazard ratio, 0.28; 95% CI, 0.23-0.34; P<.001) after adjustments for CKD, advanced CKD, and angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use. In contrast, the risk of major adverse cardiovascular events and hospitalized heart failure did not differ significantly between groups. Conclusion: Dipeptidyl peptidase-4 inhibitor users had a lower risk of ESRD and mortality than did nonusers among patients with diabetes after weaning from dialysis-requiring AKI. Therefore, a prospective study of AKI to CKD transitions after episodes of AKI is needed to optimally target DPP4i interventions.

show abstract

Section: Strengths and Limitationsmentioning

confidence: 99%

Improvement in Mortality and End-Stage Renal Disease in Patients With Type 2 Diabetes After Acute Kidney Injury Who Are Prescribed Dipeptidyl Peptidase-4 Inhibitors

Chen

Lin

et al. 2018

Mayo Clinic Proceedings

View full text Add to dashboard Cite

show abstract

“…Our previous studies showed that RV structure, function, and mechanics were impaired in various subtypes of hypertensive patients (white‐coat and masked hypertension, prehypertension, nighttime hypertension, metabolic syndrome) . The influence of gender on RV structure and function in patients with metabolic syndrome and arterial hypertension has already been investigated .…”

Section: Introductionmentioning

confidence: 99%

Does gender affect the association between right ventricular strain and arterial hypertension?

Tadić

Cuspidi

Ivanović

et al. 2018

J of Clinical Hypertension

Self Cite

View full text Add to dashboard Cite

The importance of right ventricular (RV) structure and function in cardiovascular and total morbidity and mortality has been confirmed previously. The purpose of this study was to evaluate the influence of gender on RV structure and function in untreated hypertensive patients. This cross-sectional study included 243 subjects who underwent 24-hour ambulatory blood pressure (BP) monitoring and comprehensive echocardiographic examination including strain evaluation. There was no difference in RV diameter between hypertensive and normotensive women and men. RV wall thickness, right atrial volume index (RAVI), and tricuspid E/e' ratio were significantly higher in hypertensive women and men than in their normotensive counterparts. RV global longitudinal and RV free wall longitudinal strains were significantly lower in hypertensive women and men than in their normotensive counterparts. Arterial hypertension affected RV wall thickness, RAVI, tricuspid E/e', and RV longitudinal strain. Gender affected RV diameter, RAVI, tricuspid E/e', and RV longitudinal strain, whereas hypertension-gender interaction affected RAVI, E/e', and RV longitudinal strain. The 24-hour systolic BP and LV mass index were independently associated with RV free wall longitudinal strain. RV wall thickness was independently associated with RV free wall longitudinal strain only in women, and tricuspid E/e' was independently associated only in men. In conclusion, RV longitudinal strain was significantly decreased in hypertensive patients in both sexes. Hypertensive men suffered more evident RV mechanical changes than hypertensive women. Gender, arterial hypertension, and their interaction had the important role in RV structural and mechanical remodeling.

show abstract

“…Despite cost-effectiveness and wide availability of echocardiography, RV anatomy and positioning within the chest leads to reproducibility issues with ultrasoundbased strain assessments (Bossone et al, 2013). Additionally, unlike the LV, circumferential and radial ultrasound-based strains are challenging to measure for the RVFW (Tadic et al, 2018). cMRI is a more accurate technique for in vivo RVFW strain measurements.…”

Section: Effects Of Pah On Rv Wall Stress and Contractile Strainsmentioning

confidence: 99%

Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension

2021

View full text Add to dashboard Cite

Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular (RV) afterload and RV remodeling. PAH results in altered RV structure and function at different scales from organ-level hemodynamics to tissue-level biomechanical properties, fiber-level architecture, and cardiomyocyte-level contractility. Biomechanical analysis of RV pathophysiology has drawn significant attention over the past years and recent work has found a close link between RV biomechanics and physiological function. Building upon previously developed techniques, biomechanical studies have employed multi-scale analysis frameworks to investigate the underlying mechanisms of RV remodeling in PAH and effects of potential therapeutic interventions on these mechanisms. In this review, we discuss the current understanding of RV structure and function in PAH, highlighting the findings from recent studies on the biomechanics of RV remodeling at organ, tissue, fiber, and cellular levels. Recent progress in understanding the underlying mechanisms of RV remodeling in PAH, and effects of potential therapeutics, will be highlighted from a biomechanical perspective. The clinical relevance of RV biomechanics in PAH will be discussed, followed by addressing the current knowledge gaps and providing suggested directions for future research.

show abstract

Right heart remodeling induced by arterial hypertension: Could strain assessment be helpful?

Cited by 23 publications

References 40 publications

Improvement in Mortality and End-Stage Renal Disease in Patients With Type 2 Diabetes After Acute Kidney Injury Who Are Prescribed Dipeptidyl Peptidase-4 Inhibitors

Improvement in Mortality and End-Stage Renal Disease in Patients With Type 2 Diabetes After Acute Kidney Injury Who Are Prescribed Dipeptidyl Peptidase-4 Inhibitors

Does gender affect the association between right ventricular strain and arterial hypertension?

Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension

Contact Info

Product

Resources

About