Right-Handed Helical Structure of Expanded Oligo(<scp>l</scp>-leucine) Containing [Ru(terpyridine)<sub>2</sub>]<sup>2+</sup> Moieties

Okamura, Taka‐aki; Iwamura, Taku; Seno, Shuichiro; Yamamoto, H.; Ueyama, Norikazu

doi:10.1021/ja044310j

Cited by 33 publications

(39 citation statements)

References 24 publications

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“…Although many other systems have been reported in the literature [57], strong coupling between the metal centers, and, therefore, cooperative phenomena are generally not observed because the distance between the metal centers is too large [58]. The rich chemistry of terpyridines has afforded a number of other interesting ligands with photoluminescent properties, as reported by Würthner and co-workers [59,60], as well as chiral coordination polymers [61,62].…”

Section: Metallo-supramolecular Polymersmentioning

confidence: 99%

Metallo-supramolecular modules as a paradigm for materials science

Kurth

2008

Science and Technology of Advanced Materials

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Metal ion coordination in discrete or extended metallo-supramolecular assemblies offers ample opportunity to fabricate and study devices and materials that are equally important for fundamental research and new technologies. Metal ions embedded in a specific ligand field offer diverse thermodynamic, kinetic, chemical, physical and structural properties that make these systems promising candidates for active components in functional materials. A key challenge is to improve and develop methodologies for placing these active modules in suitable device architectures, such as thin films or mesophases. This review highlights recent developments in extended, polymeric metallo-supramolecular systems and discrete polyoxometalates with an emphasis on materials science.

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Section: Metallo-supramolecular Polymersmentioning

confidence: 99%

Metallo-supramolecular modules as a paradigm for materials science

Kurth

2008

Science and Technology of Advanced Materials

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“…6 Alternatively, Ueyama et al reported a helical synthetic metallopeptide containing [Ru II (terpy) 2 ] 2+ (terpy: terpyridine) moieties in the main chain as a metallated synthetic amino acid, in which the Ru II moieties serve as an artificial rigid amino acid to control the peptide conformation. 7 Organometallic ferrocene was also incorporated as a structural or functional unit into the side chain, main chain, and terminus of peptides to induce secondary structures such as helical, turn, and sheet.…”

Section: ç Design Outline Of Metallopeptidesmentioning

confidence: 99%

Stimuli-responsive Synthetic Metallopeptides

Tashiro

Shionoya

2013

Chemistry Letters

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Inspired by vital roles of metal ions as structure-stabilizing and regulating factors in biological systems, a great number of synthetic metallopeptides have been developed. This review focuses on metal-mediated stabilization and stimuli-responsive regulation of their secondary and higher-order structures by taking advantage of the characteristics of metal ions such as Lewis acidity, ligand-exchange ability, and redox properties. Ç IntroductionIn metal-including biomolecules such as metalloproteins or enzymes in living systems, metal ions play vital roles in molecular recognition, catalytic reaction, transportation, electron transfer, and structure stabilization or regulation.1 Focusing on a few examples of metal-mediated formation of higher-order structures of proteins, a typical example is zinc-finger proteins, which are composed of multiple finger units containing one Zn II ion bound by four coordinating side chains of His and/or Cys residues. The Zn II ions are well-known to stabilize the whole ternary structures and essential for DNA binding.2 In other cases, several metal ions such as Zn II , Cu II , and Fe III are considered a trigger for protein aggregations through interactions with some protein domains as seen in several brain disorders such as Alzheimer's disease and Parkinson's disease, 3 in which metal ions serve as inducers of protein folding or aggregation. On the other hand, metal ions in some proteins can regulate their higherorder structures through response to several stimuli, and the structural transformation is involved in protein functions. Hemoglobin is a typical example of such proteins, 4 that is a tetrameric protein in which O 2 trapping at the Fe II center of one heme unit induces the whole conformation change (T ¼ R transition) to achieve cooperative binding of molecular oxygens. One way to understand and further utilize such protein natures is a synthetic approach to stimuli-responsive mechanisms inspired by natural metalloproteins.For this purpose, design-based incorporation of metal binding sites into peptide structures has been extensively conducted. Synthetic peptides developed so far can be categorized as two types: (i) natural ¡-peptides possessing an optional sequence that can bind to metal ions through their coordinating functionalities of the residues or (ii) unnatural peptides containing synthetic amino acid residues whose side and/or main chains bind to metal ions. So far, many types of synthetic peptides have been reported based on both strategies, and the stabilization of secondary and higher-order structures of their metallopeptides has been demonstrated. Moreover, the metalmediated regulation of peptide structures has been recently studied based on the characteristics of metal ions such as Lewis acidity, ligand-exchange ability, and redox properties (Figure 1). This review describes the design outline of metallopeptides and then metal-mediated stabilization of ¡-helix and ¢-sheet structures taking a few basic examples of stimuli-responsive folding. The structu...

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“…Oligomers 57 a-57 d display righthanded helical structures in solution according to spectroscopic measurements. [92] Porphyrinato-zinc(II) amino acid 46 c has been incorporated into triad 58 with a carotenoid as electron donor and a tris(heptafluoropropyl)porphyrin as electron acceptor, displaying characteristics of an artificial photosynthetic reaction centre (Scheme 27). [93] Metal-free porphyrin amino acid derivatives have been conjugated to switchable organic chromophores and the resulting conjugates have been shown to act as logic gates and molecular switches.…”

Section: Wwwchemeurjorgmentioning

confidence: 99%

Solid‐Phase Synthesis of Transition‐Metal Complexes

Heinze

Beckmann

Hempel

2008

Chemistry A European J

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This overview highlights recent progress in the field of selective construction of linear, oligonuclear transition-metal complexes by using solid-phase synthesis procedures. Two general protocols have been identified: formation of coordinative bonds between metal centres and bridging ligands and formation of covalent bonds between preformed kinetically inert transition-metal-containing building blocks in the chain growth step. Currently available suitable building blocks for the second approach are based on ferrocene units, bis(terpyridine)-ruthenium(II) moieties or metal porphyrins.

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Right-Handed Helical Structure of Expanded Oligo(l-leucine) Containing [Ru(terpyridine)₂]²⁺ Moieties

Cited by 33 publications

References 24 publications

Metallo-supramolecular modules as a paradigm for materials science

Metallo-supramolecular modules as a paradigm for materials science

Stimuli-responsive Synthetic Metallopeptides

Solid‐Phase Synthesis of Transition‐Metal Complexes

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Right-Handed Helical Structure of Expanded Oligo(l-leucine) Containing [Ru(terpyridine)2]2+ Moieties

Cited by 33 publications

References 24 publications

Metallo-supramolecular modules as a paradigm for materials science

Metallo-supramolecular modules as a paradigm for materials science

Stimuli-responsive Synthetic Metallopeptides

Solid‐Phase Synthesis of Transition‐Metal Complexes

Contact Info

Product

Resources

About

Right-Handed Helical Structure of Expanded Oligo(l-leucine) Containing [Ru(terpyridine)₂]²⁺ Moieties