Right ectopic sphenoid sinus pituitary adenoma

Brito, Lara Bonani de Almeida; Tinoco, Paulo; Tinoco, Túlio; Ferreira, Flavia Rodrigues; Carrara, Vânia Lúcia

doi:10.1016/j.bjorl.2014.05.022

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…It is worth noting that ectopically deposited cells have the infrequent potential to give rise to adenomas at various locations along this migratory pathway [ 1 , 9 , 10 ]. Since its first description by Erdheim in 1909, several ectopic sites have been reported, namely, sphenoid sinus, clivus, parapharyngeal space, nasal cavity, nasopharynx, third ventricle, and suprasellar region [ 2 , 4 , 11 ]. These rare neoplasms have a minor female predominance (1.3 : 1) with most patients presenting in the 6 th decade [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…These rare neoplasms have a minor female predominance (1.3 : 1) with most patients presenting in the 6 th decade [ 9 ]. Approximately, two-thirds of EPAs are located in the sphenoid sinus and suprasellar region [ 11 ]. The clinical features of an EPA are highly dependent on its hormonal activity, anatomical location, and its local mass effect [ 9 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is essential that the evaluation of these ectopic tumors be conducted using appropriate radiological imaging. Imaging investigations will not only show a normal pituitary gland and sellar turcica but will also show the size of the tumor, provide details on its margins, and extent and help with surgical planning [ 9 , 11 ]. Traditionally, MRI shows mild to moderate heterogenous contrast enhancement, without a unique T1- or T2-weighted image intensity, whereas nonenhanced CT demonstrates tumors that are iso to hypodense to grey matter, showing modest enhancement in postcontrast studies [ 1 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Null-Cell Ectopic Pituitary Adenoma of the Nasal Cavity

Figaro,

Juman,

Ramsundar

et al. 2023

Case Reports in Otolaryngology

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An ectopic pituitary adenoma (EPA) is an uncommon type of pituitary adenoma, accounting for only 2% of all pituitary adenomas. EPAs are benign tumors that can occur anywhere along the migratory embryonic path of the pituitary gland and have no relationship to intrasellar elements. They are usually hormonally active and have a minor female predominance. The clinical features of EPAs are highly dependent on its hormonal activity, anatomical location, and its local mass effect. Appropriate radiological imaging is essential for the evaluation of EPAs. Imaging investigations show a normal pituitary gland and sellar turcica, provide details on the size of the tumor, its margins, and extent, and help with surgical planning. The criteria for diagnosing an ectopic pituitary adenoma depend on detailed histopathological examination. EPA management should be individualized. We present a case of a 71-year-old male who presented with a 9-month history of left nasal obstruction, purulent nasal discharge, and intermittent anterior epistaxis. The patient was being managed by his general practitioner for chronic rhinosinusitis but failure of his symptoms to resolve prompted a visit to the otorhinolaryngologist. The patient was diagnosed with a null-cell ectopic pituitary adenoma through histological analysis of a biopsy specimen that showed adenohypophyseal cells without cell-type-specific differentiation. The patient subsequently underwent an endoscopic endonasal excision and had an uneventful hospital stay.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Null-Cell Ectopic Pituitary Adenoma of the Nasal Cavity

Figaro,

Juman,

Ramsundar

et al. 2023

Case Reports in Otolaryngology

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“…[20] Ectopic pituitary adenomas are derived from embryologic remnants along the path of migration of Rathke's pouch, and more than fifty ectopic pituitary adenomas have been reported. [21] Ectopic pituitary adenomas may be found in the sphenoid sinus region, clivus, parapharyngeal space, nasal cavity and nasopharynx, hypothalamus, third ventricle, and in the suprasellar locations. [22] About two-thirds are hormonally active adenomas.…”

Section: Discussionmentioning

confidence: 99%

Isolated Sphenoid Sinus Lesions: Experience with a Few Rare Pathologies

Sadashiva

Nandeesh

Shukla

et al. 2017

Journal of Neurosciences in Rural Practice

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Introduction:The sphenoid sinus is often neglected because of its difficult access. The deep position of the sphenoid sinus hinders early diagnosis of pathologies in that location. Delayed diagnosis can cause serious complications due to proximity to many important structures.Objectives:The aim of this study is to demonstrate different pathologies which can affect the sphenoid sinus and elucidate the findings.Methods:Cases of isolated sphenoid sinus lesions encountered in the neurosurgical setting which had rare pathologies are discussed. Pathologies such as Langerhans cell histiocytosis, solitary plasmacytoma, chordoma, pituitary adenoma, leiomyosarcoma, fungal infection, and mucocele which appeared primarily in sphenoid sinus are discussed along with their imaging features and pathological findings.Conclusion:Multitude of different pathologies can occur in sphenoid sinus. Detailed preoperative imaging is very helpful, but transnasal biopsy and histological study are required often for definitive diagnosis. The possible advantages of early diagnosis before spread of pathology for prognosis cannot be overemphasized.

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“…Ectopic pituitary adenomas are more prevalent among females (62%) over the age of 50 years. Of these ectopic tumors, 40% are located in the sphenoid sinus and 33% in the suprasellar region [4]. Approximately one-third of these tumors do not secrete hormones and the remaining two-thirds usually secrete ACTH and can thus trigger the signs and symptoms of Cushing disease [5].…”

Section: Introductionmentioning

confidence: 99%

Cushing Disease Due to Ectopic Pituitary Adenoma.

2019

gjsst

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Adrenocorticotropic hormone (ACTH) - secreting pituitary adenomas are the most common cause of Cushing disease. A pituitary adenoma is rarely ectopic and suprasellar dependent (ectopic) ACTH -secreting pituitary tumors are extremely rare, with few cases described in the literature. Therefore, this study aimed to report the case of a patient with a diagnosis of Cushing disease because of a suprasellar ACTH-secreting tumor attached to the pituitary stalk, requiring a craniotomy.

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Right ectopic sphenoid sinus pituitary adenoma

Cited by 5 publications

References 6 publications

Null-Cell Ectopic Pituitary Adenoma of the Nasal Cavity

Null-Cell Ectopic Pituitary Adenoma of the Nasal Cavity

Isolated Sphenoid Sinus Lesions: Experience with a Few Rare Pathologies

Cushing Disease Due to Ectopic Pituitary Adenoma.

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