Right Atrial Intimal Sarcoma on 18F-FDG PET/CT

Janssen, Nick; Verheyen, Jef; Albert, Adrien

doi:10.1097/rlu.0000000000003051

Cited by 3 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through a backward citation search, 24 additional articles were retrieved, bringing the total to 74 articles included in this study. Figure 1 shows the preferred reporting items for systematic reviews and meta-analyses (PRISMA) flowchart and screening methods, while Table 1 displays the general characteristics of the patient population [18–85] .…”

Section: Resultsmentioning

confidence: 99%

“…Todo et al [18] 78 M Symptoms of heart failure Bilateral lungs NA Nakagawa-Kamiya et al [19] 45 M Cough, palpitations, weight loss, and hyperhidrosis None NA Janssen et al [20] 81 M Routine follow-up visit NA NA Grant et al [21] 31 F Left-sided weakness NA NA Fu et al [22] 50 M Progressive shortness of breath and diminished exercise tolerance NA NA Genc et al [23] 47 M Dyspnea and fatigue, and right leg edema NA NA Zhang et al [24] 57 M Acute onset of chest pain and shortness of breath NA NA Nassereddine et al [25] 70 F Dyspnea NA N/A Raphael et al [3] 49 F Unexplained fever, malaise, and generalized aches NA Hospice…”

Section: First Author Age Gender Clinical Features Metastasis Outcomementioning

confidence: 99%

See 1 more Smart Citation

Cardiac intima sarcoma: a rapid review of case reports

Awoyemi,

Gwira-Tamattey,

Oluwole

et al. 2024

Cardiology Plus

View full text Add to dashboard Cite

Background and purpose: Cardiac intimal sarcoma (CIS) is a rare and often misdiagnosed clinical entity with notably high morbidity and mortality rates. Urgent efforts are required to comprehensively the disease and establish evidence-based management guidelines. Given the relative scarcity of data and the imperative for consensus on management strategies, this review assumes critical importance. Through a rapid review approach, we aims to synthesize and consolidate information gleaned from published case reports, thereby offering an up-to-date resource for CIS’s natural history. Methods: Utilizing inductive content analysis, we systematically searched for and synthesized case reports and series. Keywords related to CIS guided our search on Medline via Ovid, Scopus, and Web of Science from inception until March 17, 2024. Results: Our review identified 79 CIS, characterized by a mean age of 52 years, predominantly male (58%), with left-sided lesions. Approximately one-third of the patients presented with cardiovascular symptoms, and transthoracic echocardiography emerged as the preferred initial diagnostic modality in most cases. Fluorescence in situ hybridization (FISH) analysis on pre-operative tissue biopsies found murine double minute 2 (MDM2) amplification in 95% of cases tested. While surgery remained the cornerstone of treatment, recurrence occurred in 14% of cases postoperatively, with 28% succumbing to the disease despite therapeutic interventions. Conclusions: This synthesis of published case reports and series provides updated insights into the clinical profile CIS. Our findings highlight the need for increased clinical awareness, precise data collection, and further research to enhance diagnostic accuracy, treatment approaches, and patient outcomes in CIS.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: First Author Age Gender Clinical Features Metastasis Outcomementioning

confidence: 99%

Cardiac intima sarcoma: a rapid review of case reports

Awoyemi,

Gwira-Tamattey,

Oluwole

et al. 2024

Cardiology Plus

View full text Add to dashboard Cite

show abstract

“…CT can assess tissue features, vascularity, adjacent infiltrates and extracardiac metastases, and cardiac magnetic resonance imaging (MRI) is the standard diagnostic tool ( 14 ). 18F-FDG positron emission computed tomography (PET/CT) infers the presence of a malignant process based on the FDG uptake of the mass, and IS has a high FDG uptake ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

A case of left atrial intimal sarcoma with rhabdomyosarcoma differentiation: a case report and literature review

Shu,

Xiao,

Han

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

Primary cardiac malignancies are rare, with cardiac sarcomas being the main type. Among these, intimal sarcomas are the most common. However, they tend to occur in the great vessels and are rare in the heart, with only a few isolated cases reported. We report a challenging case of a patient with left atrial intimal sarcoma with rhabdomyosarcoma differentiation. The patient was admitted after a physical examination detected left heart occupancy, and initial imaging suspected a left atrial thrombus. The patient then underwent extracorporeal circulation-assisted open cardiac surgery with resection of an atrial mass. The postoperative pathological findings were suggestive of an arterial intimal sarcoma, which included areas of rhabdomyosarcoma differentiation within the tumor tissue. Unfortunately, the patient’s tumor recurred 4 months later, and she died due to treatment failure. This case highlights the rarity and risk of misdiagnosis of cardiac intimal sarcoma. Additionally, we aim to improve the understanding of intimal sarcoma through a review of immunohistochemistry and gene amplification techniques.

show abstract