Right- and left-handed helixes of poly[d(A-T)].cntdot.poly[d(A-T)] investigated by infrared spectroscopy

Adam, S.; Liquier, J.; Taboury, Jean; Taillandier, E.

doi:10.1021/bi00359a021

Cited by 74 publications

(34 citation statements)

References 33 publications

(42 reference statements)

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“…From theoretical considerations (3), phosphate groups also appear to be the most likely association sites for water in nucleic acids. Furthermore, the manner in which water molecules are organized around DNA through PO;-metal-water interactions seems to be an important factor in the stabilization of specific DNA conformations (4).…”

Section: Introductionmentioning

confidence: 99%

Vibrational spectroscopic study of the interaction of metal ions with diethyl phosphate, a model for biological systems

Stangret¹,

Savoie²

1992

Can. J. Chem.

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JANUSZ STANGRET and RODRIGUE SAVOIE. Can. J. Chem. 70, 2875Chem. 70, (1992. We have studied, using Raman and infrared spectroscopy, the interaction of various monovalent, divalent, and trivalent metal cations with the PO, group of diethyl phosphate in aqueous solution, at meta1:phosphate ratios ranging from 1 :40 to 6 : 1. The results show that the metal cations interact with the phosphate groups in various ways and to different extents. Spectral characteristics for some specific types of interactions are presented, namely, for direct metal binding by one of the oxygen atoms in the PO; group, the formation of water-separated ion pairs, and non-specific electrostatic interactions.JANUSZ STANGRET et RODRIGUE SAVOIE. Can. J. Chem. 70, 2875 (1 992). Nous avons etudii par spectroscopie Raman et infrarouge l'interaction de divers cations mttalliques monovalents, divalents et trivalents avec le groupe charge PO, du phosphate de diethyle en solution aqueuse, a des rapports metal : phosphate variant de 1 : 40 5 6 : 1. Les resultats demontrent que les ions se distinguent tant par leur affinite pour le groupement phosphate que par leur f a~o n d'interagir avec celui-ci. On prtsente diverses caracttristiques spectrales permettant d'identifier certains types d'interaction, notamment la fixation directe par l'un des atomes d'oxygkne du groupement phosphate, la formation de paires d'ions stparees par molCcules d'eau et les interactions non specifiques de nature electrostatique.

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Section: Introductionmentioning

confidence: 99%

Vibrational spectroscopic study of the interaction of metal ions with diethyl phosphate, a model for biological systems

Stangret¹,

Savoie²

1992

Can. J. Chem.

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“…在基质隔离的条件下, FTIR 能识别碱基的振动光谱, 如碱基 A (adenine) [1] , T (thymine) [2] , C (cytosine) [3] 和 U (uracil) [4] , 特别是对碱基 G (guanine)异构体的研究更多, 除了在基质隔离的条件下 [5～8] , 还结合紫外光谱研究气相中的异构体 [9～11] . FTIR 还可以测量各种形态的核酸碱基对, 如液相 [12] 和晶体 [13] 中的 A-U 碱基对, 薄膜中的 A, B, C, D 和 Z 型的双螺旋聚 A-T 分子 [14] . 与紫外光谱相结合还能高分辨地区分气相中不同的 A-T 配对异构体 [15] 、G-C 配对异构体及其它碱基配对体 [16] .…”

Section: 传统的一维红外光谱(如 Ftir)具有广泛用途其中unclassified

Anharmonic Vibrations of Nucleobases: III, Structural Basis of Oneand Two-Dimensional Infrared Spectra for DNA Stacking Dimers

王桂秀¹,

王建平²

2012

Acta Chim. Sinica

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In this work, DNA base monomers, 15 B-form stacking dimers and two G-quadruplex stacking dimers were studied by quantum chemical computations. Detailed anharmonic vibrational analysis was carried out to reveal vibrational signatures for structural aspect of the base monomers and dimers. It was found that from isolated base monomers to stacking dimers, particularly those containing guanine, the interaction between the C＝O stretching is very strong, as depicted by the significant changes of their vibrational frequencies and anharmonicities. Such changes can be manifested well in simulated 1D IR and 2D IR spectra. Delocalization degree of the C＝O vibrational modes in stacking dimers, represented by the potential energy distribution and the contribution to the diagonal anharmonicity composition from the vibrators, was found to have significant variations in comparison with isolated bases, which resulted from the influences of the C＝ O stretching and the nearby vibrations of stacking bases.

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“…FTIR spectroscopy also has been widely used by organic chemists to characterize the compounds synthesized by them [12]. In addition, it has become a powerful tool for investigation of the three-dimensional structure of various biomolecules such as proteins [13], nucleic acids [14], and lipids [15]. Inspire by those outstanding results, there are many researchers who explore and apply FTIR in cervical cancer.…”

Section: B Ftir In Cervical Cancermentioning

confidence: 99%

Capability of new features from FTIR spectral of cervical cells for cervical precancerous diagnostic system using MLP networks

Jusman

Sulaiman

Isa

et al. 2009

TENCON 2009 - 2009 IEEE Region 10 Conference

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Abstract-The applicability and reliability of Infrared (IR) spectroscopy to distinguish normal and abnormal cells has opened this research to obtain new features from IR spectral of cervical cells to be fed into multilayered perceptrons (MLP) networks. In order for neural networks to be used as cervical precancerous diagnostic system, the features of cervical cell were used as inputs for neural networks and the classification of cervical cell types were used as output target. For cervical cell classification, this study proposes new features of cervical cell spectrum that are suitable and can be used as inputs for neural networks. The new cervical cell features were extracted from ThinPrep® spectrum and their applicability were tested by using seven types of MLP training algorithm. The MLP network trained using Levenberg-Marquardt Backpropogation (trainlm) algorithm presented the highest accuracy with percentage of 97.3%. The result shows that the proposed features i.e. area under spectrum at 1800-1500 cm -1 , area under spectrum at 1200-1000 cm -1 , area under spectrum at 1800-950 cm -1 , height of slope at 1650-1550 cm -1 , corrected area of protein band at 1590-1490 cm -1 , corrected area of glycogen band at 1134-985 cm -1 , corrected peak height protein (H1545) and corrected peak height glycogen (H1045) are applicable to be fed as input to neural network for cervical spectra classification in cervical precancerous diagnostic system.

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Right- and left-handed helixes of poly[d(A-T)].cntdot.poly[d(A-T)] investigated by infrared spectroscopy

Cited by 74 publications

References 33 publications

Vibrational spectroscopic study of the interaction of metal ions with diethyl phosphate, a model for biological systems

Vibrational spectroscopic study of the interaction of metal ions with diethyl phosphate, a model for biological systems

Anharmonic Vibrations of Nucleobases: III, Structural Basis of Oneand Two-Dimensional Infrared Spectra for DNA Stacking Dimers

Capability of new features from FTIR spectral of cervical cells for cervical precancerous diagnostic system using MLP networks

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