Rifampin-resistant periprosthetic joint infections are associated with worse functional outcome in both acute and chronic infection types
Tobias Baumgärtner,
Mohamad Bdeir,
Franz-Joseph Dally
et al.
Abstract:Periprosthetic joint infections (PJI) pose a significant challenge in orthopaedic surgery, often requiring extensive surgical debridement and prolonged antibiotic treatment to eliminate the causative pathogens. Rifampin, known for its potent activity against biofilms, has been crucial in managing PJI by penetrating and disrupting these formations, thereby improving treatment efficacy. In this sense, antibiotic protocols lacking rifampin have shown increased failure rates. Consequently, the development of rifam… Show more
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