Rifampin and Triclosan but not Silver is Effective in Preventing Bacterial Infection of Vascular Dacron Graft Material

Hernandez-Richter, T.; Schardey, H. M.; Wittmann, F; Mayr, Stefan; Schmitt‐Sody, Marcus; Blasenbreu, S; Heiss, M. M.; Gabka, Christian J.; Angele, Martin K.

doi:10.1016/s1078-5884(03)00344-7

Cited by 82 publications

(55 citation statements)

References 31 publications

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“…Coatings containing combinations of antibiotics and antiseptics like minocycline and rifampin or chlorohexidin and silver-sulfadiazine have been applied to the internal and external surface of catheters. In several studies these antimicrobial coated catheters were compared to non-coated catheters, and a reduction of catheter colonization and catheter related blood-stream infections were found [66][67][68]. The antimicrobial effect of antibiotics containing coatings was more pronounced than for the antiseptic coatings.…”

Section: Antibiotic Releasing Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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Bacterial infection from medical devices is a major problem and accounts for an increasing number of deaths as well as high medical costs. Many different strategies have been developed to decrease the incidence of medical device related infection. One way to prevent infection is by modifying the surface of the devices in such a way that no bacterial adhesion can occur. This requires modification of the complete surface with, mostly, hydrophilic polymeric surface coatings. These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. Incorporation of antimicrobial agents in the bulk material or as a surface coating has been considered a viable alternative for systemic application of antibiotics. However, the manifestation of more and more multi-drug resistant bacterial strains restrains the use of antibiotics in a preventive strategy. The application of silver nanoparticles on the surface of medical devices has been used to prevent bacterial adhesion and subsequent biofilm formation. The nanoparticles are either deposited directly on the device surface, or applied in a polymeric surface coating. The silver is slowly released from the surface, thereby killing the bacteria present near the surface. In the last decade there has been a surplus of studies applying the concept of silver nanoparticles as an antimicrobial agent on a range of different medical devices. The main problem however is that the exact antimicrobial mechanism of silver remains unclear. Additionally, the antimicrobial efficacy of silver on OPEN ACCESSPolymers 2011, 3 341 medical devices varies to a great extent. Here we will review existing antimicrobial coating strategies and discuss the use of silver or silver nanoparticles on surfaces that are designed to prevent medical device related infections.

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Section: Antibiotic Releasing Coatingsmentioning

confidence: 99%

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

2011

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“…''Silver coating" of vascular prostheses was also performed for its antimicrobial effect. Goeau et al [11] and Hernandez et al [12] showed that rifampicin bonding was superior to silver coating or triclosan of vascular prostheses.…”

Section: Introductionmentioning

confidence: 99%

Polyester vascular prostheses coated with a cyclodextrin polymer and activated with antibiotics: Cytotoxicity and microbiological evaluation

et al. 2008

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“…В неко-торых работах предполагается, что миграция ионов из материала протеза в окружающие ткани вообще может не происходить [21]. Теоретические рассуждения по этому вопросу иллюстрируются данными исследований, прове-денными in vitro [34], а также in vivo на мышах [35] и сви-ньях [36]. Ряд авторов [22,36,37] приводят данные, свиде-тельствующие о том, что импрегнированные серебром протезы уступают по эффективности пропитанным анти-биотиком или антисептиком.…”

Section: Discussionunclassified

The choice of vascular prosthesis in high-risk aortic surgery

Andreychuk¹

2016

Kardiol. serdechno-sosud. khir.

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nikiforov all-Russian emergency and radiation medicine, Ministry of emergency situations, St. Petersburg, Russia the retrospective comparative analysis of prosthetic graft infection rate was done in two comparable groups. 267 high-risk patients underwent aortoiliac vascular procedures with implantation of silver-coated (Silvergraft, B.BRAun, germany) (main group, n=113) or simple dacron grafts (control group, n=154) in a single center. 22 cases of graft infection occurred (8.2%) 17 (77.3%) of which were registered in control group. Significant difference (p=0.0192) in infection rate between study groups had been revealed as early as one month and has been at the high by eight months. 45.5% of patients (all of them from control group) died due to infectious complications (sepsis, arrosive hemorrhage, endocarditis, multiorgan dysfunction) in 3-69 months' follow-up period. In conclusion, silver-coated grafts have a benefit in prevention of early and late infectious complication and prosthetic aortoiliac graft infection by high-risk patients.

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Rifampin and Triclosan but not Silver is Effective in Preventing Bacterial Infection of Vascular Dacron Graft Material

Abstract: Silver coating failed to prevent graft infection material. A potential antimicrobial property was evident for Triclosan whereas Rifampin-bonded grafts exhibit a significantly reduced infection rate. Thus, silver-coated vascular grafts cannot ensure protection from vascular graft infection.

Cited by 82 publications

References 31 publications

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

New Strategies in the Development of Antimicrobial Coatings: The Example of Increasing Usage of Silver and Silver Nanoparticles

Polyester vascular prostheses coated with a cyclodextrin polymer and activated with antibiotics: Cytotoxicity and microbiological evaluation

The choice of vascular prosthesis in high-risk aortic surgery

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