Rifampicin Sensitivity of Clinical Staphylococcal Strains and the Development of Resistance During Rifampicin Therapy

Samoilova, L. N.; Bodunkova, L. E.; Fomina, I P; Navashin, S M

doi:10.1007/978-3-642-66062-7_33

Drug-Inactivating Enzymes and Antibiotic Resistance 1975

DOI: 10.1007/978-3-642-66062-7_33

|View full text |Cite

Rifampicin Sensitivity of Clinical Staphylococcal Strains and the Development of Resistance During Rifampicin Therapy

L. N. Samoilova¹,

L. E. Bodunkova²,

I P Fomina³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1981

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, rifampin is being used with increasing frequency for the therapy of selected staphylococcal infections in humans (1,3,4,13,18). However, rifampin-resistant organisms readily develop, and this may compromise the continuing therapeutic applications of the drug (11,14,15,17).…”

mentioning

confidence: 99%

Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphylococcus aureus

Moorman¹,

Mandell²

1981

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Twenty clinical isolates of Staphylococcus aureus were examined to determine the frequency of rifampin-resistant variants. All isolates were highly susceptible to rifampin, with mean minimum inhibitory concentrations of 0.11 ± 0.1 ,ug/ml and mean minimum bactericidal concentrations of 0.22 ± 0.2 ,ug/ml. The frequency of isolation of resistant variants was similar at all rifampin concentrations tested. Rifampin-resistant variants maintained their resistance upon daily subculture in rifampin-free broth. Rifampin-susceptible S. aureus exhibited a growth and survival advantage over the rifampin-resistant mutants both in pure cultures and in mixtures with rifampin-resistant antecedents. A comparison of the virulence for mice of five susceptible isolates and their 100 ,ug/ml-rifampin-resistant variants showed that two of the resistant variants were less virulent than the susceptible strains via intraperitoneal challenge, whereas three of the resistant variants were less virulent by intravenous challenge (P < 0.05).Rifampin is a potent antistaphylococcal agent, highly efficacious for the treatment of experimental staphylococcal infections (2,9,11,14). Consequently, rifampin is being used with increasing frequency for the therapy of selected staphylococcal infections in humans (1,3,4,13,18). However, rifampin-resistant organisms readily develop, and this may compromise the continuing therapeutic applications of the drug (11,14,15,17).The present study examines the frequency of resistance in 20 clinical isolates of Staphylococcus aureus to several concentrations of rifampin. The stability and growth of rifampin-resistant variants in vitro were measured, and the virulence of these variants was determined in mice.MATERIALS AND METHODS

show abstract

mentioning

confidence: 99%

Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphylococcus aureus

Moorman¹,

Mandell²

1981

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Rifampicin Sensitivity of Clinical Staphylococcal Strains and the Development of Resistance During Rifampicin Therapy

Cited by 1 publication

References 3 publications

Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphylococcus aureus

Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphylococcus aureus

Contact Info

Product

Resources

About