Rifampicin-induced nephrotoxicity in a tuberculosis patient

Beebe, Alexandria; Seaworth, Barbara; Patil, Naveen

doi:10.1016/j.jctube.2015.09.001

Cited by 22 publications

(22 citation statements)

References 10 publications

(18 reference statements)

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“…On the other hand, disadvantages include potential drug interactions of HAART with rifampicin, thus limiting co-administration of selected protease inhibitors (PIs), cumulative toxicity, therapeutic failure, and the risk of immune reconstitution inflammatory syndrome (IRIS), which affect the long-term adherence to HAART in MTB-infected patients ( 50 ). Furthermore, non-compliance due to pill burden, side effects of medications, accessibility of treatment centers for HIV and TB, fears of stigmatization, cost of healthcare, and lack of proper health education are also major problems that need to be addressed to successfully treat MTB patients ( 51 ). In general, the priority should be to provide directly observed therapy (DOT) for these patients to ensure compliance and treatment success ( 10 ).…”

Section: Clinical Management Of Mycobacterium Tuberculosis mentioning

confidence: 99%

HIV-Associated TB Syndemic: A Growing Clinical Challenge Worldwide

Montales

Chaudhury

Beebe

et al. 2015

Front. Public Health

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The association of tuberculosis (TB) with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome over the past several years has become an emerging syndemic. Approximately 10% of people living with HIV (PLHIV) with latent TB infection will develop active TB disease each year. In this review, we highlight that this phenomenon is not limited to high endemic regions, such as Afro-Asian nations, but globalization/migration is causing increased case detection even in developed nations, such as the United States. Active screening should be performed for TB in PLHIV. A high degree of clinical suspicion for TB is warranted in PLHIV presenting with fever, cough, and unintentional weight loss. HIV–Mycobacterium tuberculosis (MTB) coinfection is often paucibacillary, precluding diagnosis by conventional diagnostics and/or smear microscopy/culture. Improved detection of pulmonary and extrapulmonary TB is now possible by incorporation of the GeneXPERT MTB/RIF assay (Cepheid Inc., Sunnyvale, CA, USA). The World Health Organization recommends instituting immediate therapy for MTB, in conjunction with ongoing or newly introduced anti-retroviral therapy. Vigilance is required to detect drug-induced organ injuries, and early-treatment-induced immune reconstitution inflammatory syndrome. Collaborating MTB and HIV activities in concentrated HIV epidemic settings should become a high public health priority.

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Section: Clinical Management Of Mycobacterium Tuberculosis mentioning

confidence: 99%

HIV-Associated TB Syndemic: A Growing Clinical Challenge Worldwide

Montales

Chaudhury

Beebe

et al. 2015

Front. Public Health

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“…The most common cause of acute kidney injury triggered by rifampin has tubular damage manifesting as AIN, ATN, and light-chain proteinuria [ 4 , 7 , 11 , 12 ]. One less common cause noted for AKI is diffuse proliferative crescentic glomerulonephritis [ 11 ]. ATN is mainly immune-mediated and is related to the formation of rifampin IgG and IgM antibodies in previous exposure to the drug [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Rifampin-Induced Acute Intravascular Hemolysis Leading to Heme Pigment-Related Kidney Injury

Sanwal¹,

Kaldas²,

Surani

et al. 2020

Cureus

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Rifampin-induced acute kidney injury is very rare. Most cases of acute renal injury from rifampin use are related to acute tubular necrosis and acute interstitial nephritis. In this case report, we detail a unique presentation of rifampin-associated acute intravascular hemolysis and subsequent tubular injury in a tuberculosis patient. The patient had presented to the hospital with acute kidney injury and oliguria from intravascular volume depletion secondary to intractable vomiting. The patient had stopped taking his antituberculosis medications two weeks before hospitalization. At the time of hospital admission, his antituberculosis regimen of rifampin and isoniazid was reinstituted. Within four days of initiation of rifampin, he developed acute hemolytic anemia. His kidney biopsy revealed hemoglobin pigment deposition in the kidney tubules. Rifampin was discontinued, and he received a total of eight hemodialysis treatments spanning over 17 days. Subsequently, after discontinuing rifampin, his anemia and oliguria resolved with renal function markedly improved to near normal baseline levels. This case report also offers a review of known mechanisms of rifampin-induced acute hemolysis and acute renal failure, along with a discussion of contemporary literature.

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“…Meningitis TB treatment is challenging because of the poor penetration of drugs (e.g., rifampin and streptomycin) into the CSF due to the impervious blood–brain barrier ( 70 ). EPTB is curable with ATT drugs only to an extent and may result in several complications; for example, patients on ATT treatment may develop acute kidney injuries and increase the risk for nephrotoxicity neuropathy and CNS toxicity ( 71 – 73 ). EPTB treatment also has some exclusion criterion; i.e., chemotherapy is detrimental during the first trimester of pregnancy as it prompts pregnancy termination.…”

Section: Treatment Challenges Of Eptb With An Emphasis On Fgtbmentioning

confidence: 99%

Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors

Gupta

2020

Front. Immunol.

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Extra-pulmonary tuberculosis (EPTB) is recognized mainly as a secondary manifestation of a primary tuberculosis (TB) infection in the lungs contributing to a high incidence of morbidity and mortality. The TB bacilli upon reactivation maneuver from the primary site disseminating to other organs. Diagnosis and treatment of EPTB remains challenging due to the abstruse positioning of the infected organs and the associated invasiveness of sample acquisition as well as misdiagnosis, associated comorbidities, and the inadequacy of biomarkers. Female genital tuberculosis (FGTB) represents the most perilous form of EPTB leading to poor uterine receptivity (UR), recurrent implantation failure and infertility in females. Although the number of TB cases is reducing, FGTB cases are not getting enough attention because of a lack of clinical awareness, nonspecific symptoms, and inappropriate diagnostic measures. This review provides an overview for EPTB, particularly FGTB diagnostics and treatment challenges. We emphasize the need for new therapeutics and highlight the need for the exaction of biomarkers as a point of care diagnostic. Nuclear receptors have reported role in maintaining UR, immune modulation, and TB modulation; therefore, we postulate their role as a therapeutic drug target and biomarker that should be explored in FGTB.

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Rifampicin-induced nephrotoxicity in a tuberculosis patient

Cited by 22 publications

References 10 publications

HIV-Associated TB Syndemic: A Growing Clinical Challenge Worldwide

HIV-Associated TB Syndemic: A Growing Clinical Challenge Worldwide

Rifampin-Induced Acute Intravascular Hemolysis Leading to Heme Pigment-Related Kidney Injury

Etiopathogenesis, Challenges and Remedies Associated With Female Genital Tuberculosis: Potential Role of Nuclear Receptors

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