Rifampicin in the treatment of osteoarticular infections due to staphylococci

Cluzel, R; Lopitaux, R; Sirot, J.; Rampon, S

doi:10.1093/jac/13.suppl_c.23

Cited by 24 publications

(10 citation statements)

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“…In our study, elevated ALT values were rare, never reached critical levels, and were not clinically relevant. Similar results were found in previous studies in patients treated with rifampicin for staphylococcal infections [1,25,26]. These results confirm that the risk of rifampicin-induced hepatotoxicity is low even at higher dosages than that prescribed for tuberculosis, in patients who do not take isoniazid or pyrazinamide concomitantly.…”

Section: Discussionsupporting

confidence: 90%

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Lack of association between rifampicin plasma concentration and treatment‐related side effects in osteoarticular infections

Besnier

Giraudeau

Simonnard

et al. 2007

Fundamemntal Clinical Pharma

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The aim of this study was to assess the frequency of gastrointestinal side effects (GSE) and hepatotoxicity in patients treated with rifampicin for an osteoarticular infection and to determine if there is an association between rifampicin plasma concentrations and side effects. Rifampicin plasma concentrations were prospectively measured before (trough concentration, C(0)) and 2 +/- 0.5 h (peak concentration, C(2)) after drug intake. The presence of GSE, the alanine transferase (ALT) value, and concomitantly administered medications were recorded on the day rifampicin concentrations were measured. C(0) and C(2) were compared for differences regarding the presence or absence of side effects. Multivariate analysis was performed, with associated medications being taken into account. Seventy C(0) and 57 C(2) values were measured in 46 adults after a median treatment of 8 days (range, 1-179). Wide inter-individual variability was observed for C(0) and C(2). Thirteen (28%) patients reported GSE at least once. When GSE occurred, C(0) (median, 1 mg L(-1); range, 0.1-9.9 mg L(-1)) and C(2) (median, 10.3 mg L(-1); range, 1.8-40.3 mg L(-1)) were similar to C(0) (median, 0.6 mg L(-1); range, 0.1-10.3 mg L(-1)) and C(2) (median, 10.9 mg L(-1); range, 2.9-29.0 mg L(-1)) without GSE. The ALT value was more than normal in only three patients (6.5%) after rifampicin treatment began. The patients received no different associated medications whether or not GSE were present. Multivariate analysis showed no association between rifampicin plasma concentrations and GSE. GSE occur frequently in patients receiving rifampicin for osteoarticular infection but without an association with rifampicin plasma concentrations. Thus, therapeutic drug monitoring of rifampicin is irrelevant in the management of GSE.

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Section: Discussionsupporting

confidence: 90%

“…Antibiotherapy for osteoarticular infections is prolonged and frequently includes a combination of two or more antibiotics. Because of good rifampicin bioavailability, bone diffusion, and efficacy against staphylococci, rifampicin‐based antibiotic combinations play an important role in the treatment of osteoarticular infections [1–4].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between rifampicin plasma concentration and treatment‐related side effects in osteoarticular infections

Besnier

Giraudeau

Simonnard

et al. 2007

Fundamemntal Clinical Pharma

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“…Rifampin is much safer than the combination of an aminoglycoside with a lysosomotropic agent for staphylococcus-related infections, although it should not be used alone because of the rapid emergence of resistant mutants. For example, this compound has been used successfully in combination with a fluoroquinolone in patients suffering from chronic S. aureus osteoarthritis (17,31).…”

Section: Selected Examples Of Clinical Activity Of Aminoglycosidesmentioning

confidence: 99%

Use of Aminoglycosides in Treatment of Infections Due to Intracellular Bacteria

Maurin

Raoult

2001

Antimicrob Agents Chemother

111

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“…21e24 The effectiveness of rifampin-based combination therapy may be due to the high levels of rifampin achievable in bone and its bactericidal activity against organisms in biofilms. 18,25 Based on these considerations some physicians at our hospital began to treat S. aureus osteomyelitis using oral antimicrobials for at least part of the therapy. Others, mainly out of personal preference, have continued traditional approaches with prolonged courses of parenteral therapy.…”

Section: Introductionmentioning

confidence: 99%