Rifampicin for Idiopathic Granulomatous Lobular Mastitis: A Promising Alternative for Treatment

Farouk, Omar; Abdelkhalek, Mohamed; Abdallah, Ahmed; Shata, Ahmed; Senbel, Ahmed; Attia, Essam; Elghaffar, Mohamed Abd; Mesbah, Mahmoud; Soliman, Nermine Yehia; Amin, Maha M; El-Tantawy, Dina

doi:10.1007/s00268-016-3857-7

Cited by 30 publications

(28 citation statements)

References 72 publications

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“…Recent research has shown that Rifampicin could be used as a solo medical therapy in humans for chronic mastitis [44]. Cefprozil, a second-generation cephalosporins antibiotic, is approved worldwide strictly for the treatment of mastitis disease in dairy cattle.…”

Section: Discussionmentioning

confidence: 99%

The use of the Heter-LP algorithm to reposition antibiotics for managing E. coli mastitis in dairy cattle

Sharifi¹,

Shahreza²,

Pakdel³

et al. 2020

Preprint

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Mastitis, a disease with high incidence worldwide, is the most prevalent and costly disease in the dairy industry. Environmental mastitis pathogens, such as Escherichia coli (E. coli), are major etiological agents of bovine mastitis in well-managed dairy farms. However, there is still a need to develop more efficient, safe, and economical treatments for mastitis. In the current research, Heter-LP, a new system biology-based method of drug repositioning, was applied to potentially identify novel therapeutic avenues for the treatment of E. coli mastitis. On-line data repositories relevant to known diseases, drugs, and gene targets along with other specialized biological information for E. coli mastitis, including key genes with robust bio-signatures, drugs and related diseases were used as input data for analysis with the Heter-LP algorithm. Our analyses identified novel drugs such as Glibenclamide, Ipratropium, Salbutamol, and Carbidopa as possible therapeutics that could be used against E. coli mastitis. Predicted relationships can be used by pharmaceutical scientists or veterinarians to find commercially efficacious medicines or combination of two or more active compounds to treat mastitis.

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Section: Discussionmentioning

confidence: 99%

The use of the Heter-LP algorithm to reposition antibiotics for managing E. coli mastitis in dairy cattle

Sharifi¹,

Shahreza²,

Pakdel³

et al. 2020

Preprint

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“…[23] also found that antituberculous treatment was effective in the treatment of a patient with bilateral disease. Recently, Farouk et al [24] reported that in their prospective study including 30 GLM patients, rifampicin (300 mg twice daily for 6-9 months) was an effective therapy. In contrast, Sheybani et al [7] recently reported that 7 patients who also had a history of complete or incomplete antituberculous treatment showed symptom deterioration and no response to medication.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients

et al. 2018

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Background: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome. Methods: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Clinical characteristics, ultrasonography and mammography findings, laboratory tests, treatment regimens, follow-up information, and recurrences were recorded. Results: All patients were female with a median age of 29 (range 23-44) years. The most common symptom was a breast mass with or without pain. Large irregular hypoechoic masses could be found in the breast ultrasounds of 13 patients. All patients received triple antituberculous therapy. During a median follow-up period of 40 months, 3 patients were lost to follow-up; of the remaining 19 patients, 18 achieved clinical complete remission and no recurrences were observed. Conclusion: GLM is an unusual benign breast condition that mimics breast carcinoma in its clinical and imaging presentation. Antituberculous therapy seems to be an effective alternative option in the treatment of GLM.

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“…report 17% (6/65) of IdGM in Egyptian patients showing Gram-positive bacilli in their breast biopsies [146]. A prospective study suggests that treatment with rifampicine for 6-9 months led to a complete remission of IdGM in 30 patients after a 15-month follow-up [147]. It should be noted that most of the published case series of IdGM concern patients from countries where tuberculosis has a high prevalence rate [148].…”

Section: Granulomatous Mastitis Associated With Other Autoimmune Disementioning

confidence: 99%

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

Goulabchand

Hafidi

Perre

et al. 2020

JCM

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Mastitis frequently affects women of childbearing age. Of all the pathological breast conditions requiring specific management, autoimmune mastitis is in the third position after infection and breast cancer. The aim of this literature review was to make a comprehensive description of autoimmune diseases targeting the mammary gland. Four main histological patterns of autoimmune mastitis are described: (i) lymphocytic infiltrates; (ii) ductal ectasia; (iii) granulomatous mastitis; and (iv) vasculitis. Our literature search found that all types of autoimmune disease may target the mammary gland: organ-specific diseases (diabetes, thyroiditis); connective tissue diseases (such as systemic erythematosus lupus or Sjögren’s syndrome); vasculitides (granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, giant cell arteritis, polyarteritis nodosa, Behçet’s disease); granulomatous diseases (sarcoidosis, Crohn’s disease); and IgG4-related disease. Cases of breast-specific autoimmune diseases have also been reported, including idiopathic granulomatous mastitis. These breast-limited inflammatory diseases are sometimes the first symptom of a systemic autoimmune disease. Although autoimmune mastitis is rare, it is probably underdiagnosed or misdiagnosed. Early diagnosis may allow us to detect systemic diseases at an earlier stage, which could help to initiate a prompt, appropriate therapeutic strategy. In case of suspected autoimmune mastitis, we hereby propose a diagnostic pathway and discuss the potential pathophysiological pathways leading to autoimmune breast damage.

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Rifampicin for Idiopathic Granulomatous Lobular Mastitis: A Promising Alternative for Treatment

Abstract: Rifampicin is effective in the treatment of patients with IGLM with complete clinical and ultrasonographic response after 6-9 months and could be used as a solo medical therapy alternative to both surgery and corticosteroids.

Cited by 30 publications

References 72 publications

The use of the Heter-LP algorithm to reposition antibiotics for managing E. coli mastitis in dairy cattle

The use of the Heter-LP algorithm to reposition antibiotics for managing E. coli mastitis in dairy cattle

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients

Mastitis in Autoimmune Diseases: Review of the Literature, Diagnostic Pathway, and Pathophysiological Key Players

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