Introduction:Tuberculosis is an infection that mainly affects the lungs, caused by three main pathogens of the genus Mycobacteria, there are a variety of factors, both exogenous and endogenous, that facilitate its development, as well as the presence of several host variables that play a role. important in disease behavior and susceptibility to it, current treatments for sensitive TB include isoniazid, rifampicin, ethambutol and pyrazinamide, poor adherence to therapy and misadministration of these leads to the emergence of drug-resistant strains.Results: Different studies carried out have shown that there are mutations in different Mycobacterium genes that confer resistance to certain anti-tuberculosis drugs, such as isoniazid, where it was reported in a study carried out in Lima, Peru, that in patients with genetic mutations that conferred resistance to isoniazid in a sample of 777 patients evaluated, likewise >50% of patients resistant to isoniazid were reported.Methodology: A bibliographic search was carried out in databases, selecting original articles, case reports and bibliographic reviews from 2006 to 2022, using the documents that will deal with Mycobacterium resistant to isoniazid, obtaining 22 articles for the realization of this document.
Conclusion:Tuberculosis greatly affects the lungs, treatments based on anti-tuberculosis drugs have reduced effectiveness due to genetic alterations of Mycobacterium that confer resistance to drugs such as isoniazid, which suggests a major public health problem when it comes to treating this.