Riesgo de transmisión del virus de la hepatitis B de donantes de hígado anti-HBc positivos

Marugán, Rafael Bárcena; Garzón, S.; Román, A. López San; González, Exequiel; Plaza, A García; Nash, R; Muñoza, R. Férnandez; Mateosa, M.

doi:10.1016/s0025-7753(01)71746-0

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…Kidney or heart graft from HBsAg-positive/anti-HBcAg-positive donor to HBsAg-negative/IgG anti-HBcAg-positive recipient does not become newly HBsAg-positive (124,130,134). Organs from HBsAg-negative/IgG anti-HBcAg-positive donor can transmit HBV infection to HBV-negative liver recipients at a rate of 22-100% (123,(135)(136)(137)(138)(139), and the risk can be dramatically reduced for recipients who have pre-existing antibodies anti-HBsAg or who were IgG anti-HBcAg-positive (123,127,131,136,(138)(139)(140)(141). Liver graft from HBsAg-negative/IgG anti-HBc-positive donor to recipients with HBV-related cirrhosis does not affect graft or patient survival, but they are 2.5 times more likely to develop HBV recurrence (142), although those recipients who receive preemptive treatment with HBIg and lamivudine do not develop HBV recurrence (140).…”

Section: Hepatitis B Virus and Hepatitis C Virusmentioning

confidence: 99%

Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool

López-Navidad

Caballero

2003

Clinical Transplantation

132

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The terms extended donor or expanded donor mean changes in donor acceptability criteria. In almost all cases, the negative connotations of these terms cannot be justified. Factors considered to affect donor or organ acceptability have changed with time, after showing that they did not negatively affect graft or patient survival per se or when the adequate measures had been adopted. There is no age limit to be an organ donor. Kidney and liver transplantation from donors older than 65 years can have excellent graft and patient actuarial survival and graft function. Using these donors can be from an epidemiological point of view the most important factor to esablish the final number of cadaveric liver and kidney transplantations. Organs with broad structural parenchyma lesion with preserved functional reserve and organs with reversible functional impairment can be safely transplanted. Bacterial and fungal donor infection with the adequate antibiotic treatment of donor and/or recipient prevents infection in the latter. The organs, including the liver, from donors with infection by the hepatitis B and C viruses can be safely transplanted to recipients with infection by the same viruses, respectively. Poisoned donors and non-heart-beating donors, grafts from transplant recipients, reuse of grafts, domino transplant and splitting of one liver for two recipients can be an important and safe source of organs for transplantation.

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Section: Hepatitis B Virus and Hepatitis C Virusmentioning

confidence: 99%

Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool

López-Navidad

Caballero

2003

Clinical Transplantation

132

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Serologic Profile in Hepatitis B Virus and Hepatitis C Virus in a Brazilian Liver Transplant Waiting List

Almeida

Silva

Llanos

et al. 2006

Transplantation Proceedings

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Prevention of de novo hepatitis B infection in liver allograft recipients with previous hepatitis B infection or hepatitis B vaccination

Marugán

García-Hoz

Romero

et al. 2002

Am J Gastroenterology

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The presence of pretransplantation HBM in liver transplant recipients protects these patients against the development of de novo hepatitis B. This is especially important considering that there is a high prevalence of donors with positive hepatitis B core antibody (especially in some countries), and that these donors transmit HBV infection to recipients without HBM in a significant number of cases. Thus, vaccination against HBV in patients who are candidates for liver transplantation is fundamental to avoid cases of de novo hepatitis B.

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Riesgo de transmisión del virus de la hepatitis B de donantes de hígado anti-HBc positivos

Cited by 3 publications

References 19 publications

Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool

Extended criteria for organ acceptance. Strategies for achieving organ safety and for increasing organ pool

Serologic Profile in Hepatitis B Virus and Hepatitis C Virus in a Brazilian Liver Transplant Waiting List

Prevention of de novo hepatitis B infection in liver allograft recipients with previous hepatitis B infection or hepatitis B vaccination

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