Riesgo de mortalidad en diabetes diagnosticada, diabetes no diagnosticada y prediabetes en población adulta española. Estudio Asturias 1998-2004

Valdés, Sergio; Botas, Patricia; Delgado, Elías; Cadórniga, F. Díaz

doi:10.1016/s0300-8932(09)71033-4

Cited by 28 publications

(6 citation statements)

References 18 publications

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“…This is different from a majority of cohort follow‐up epidemiological studies based on cross‐sectional studies (1,2,14–18), as well as in those of the recently diagnosed (19–21,26,27,30). On the other hand, the causes of mortality were quite similar to ours in the only study in our country carried out in Asturias (25).…”

Section: Discussionsupporting

confidence: 83%

“…The annual rates for death and complications in this Mediterranean population were lower than those published in Anglo‐Saxon countries (19–23,26,27,30) except for the mortality rates observed in the UKPDS epidemiological study in which patients were younger (53 years) than those in our study (60 years) (30). Studies of recently diagnosed patients are rare in the international literature (19–28). In our country, only two follow‐up studies have been published on recently diagnosed patients with the aim to validate different coronary risk tables relative to their comparison with the accumulated incidence observed (24), or to find out the rates and causes of mortality (25).…”

Section: Discussionmentioning

confidence: 99%

“…Studies of recently diagnosed patients are rare in the international literature (19–28). In our country, only two follow‐up studies have been published on recently diagnosed patients with the aim to validate different coronary risk tables relative to their comparison with the accumulated incidence observed (24), or to find out the rates and causes of mortality (25).…”

Section: Discussionmentioning

confidence: 99%

“…There are cohort follow‐up studies based on cross‐sectional studies (6–10) or population‐based computer records (11–13) with the aim of establishing the incidence or prevalence of complications or mortality (14–18). On the other hand, studies on the incidence of complications in patient cohorts followed up from the moment of T2DM diagnosis (19–29) are more interesting, although majority only explore macrovascular disease (19,21,22) or mortality (19–21,24–28). However, the main limitation of those studies is that it is difficult to determine the start of the illness, which may be several years before clinical diagnosis (29) when blood glucose levels prior to diagnosis are not available.…”

Section: Introductionmentioning

confidence: 99%

“…Several follow‐up studies of those recently diagnosed have been carried out to validate different coronary risk tables (24) or to learn the causes of mortality in our country (25). Then again, none relative to the incidence of microvascular complications has been published.…”

Section: Introductionmentioning

confidence: 99%

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Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre

Mata-Cases

Prado-Lacueva

Salido-Valencia

et al. 2011

International Journal of Clinical Practice

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Summary Aims: To determine the microvascular and macrovascular complications and mortality incidence rates and to identify the related factors in patients recently diagnosed with type 2 diabetes between 1991 and 2000 and followed until 2006. Methods: Retrospective longitudinal study in a primary healthcare center. Patients without any measure of glycaemia in the 3 years previous to diabetes diagnosis were excluded. Annual incidence rates for microvascular and macrovascular complications and mortality were estimated. Analysis of KaplanMeier survival curves and Cox proportional risk models by gender were done. Results: Of 469 patients [mean age: 60.4 (SD 10.7) years, 53.9% women], 80 died principally of tumoral (38.7%) and cardiovascular (30%) causes. The mean follow‐up period was 8.81 years. (SD 3.21). The complication rates per 1000 patients/year (95% CI) were: microvascular complications 29.11 (22.97–36.38), macrovascular complications 24.10 (19.05–30.08) and mortality 19.23 (15.25–23.93), all of those being significantly greater in males except for cerebrovascular disease. Complications and mortality were associated with age, HbA1c, HDL‐cholesterol, blood pressure and smoking with a different significance for each gender. HbA1c was related to microvascular complications in both sexes and to macrovascular complications only in women. Conclusion: The annual rates for death and complications in a Mediterranean type 2 diabetic patient cohort followed from diagnosis were lower than those published in Anglo‐Saxon countries. Males showed higher death and complication rates except in terms of cerebrovascular disease. Predictors of complication and death were different depending on gender. In terms of mortality, unlike in other studies, only one‐third of the deaths were for cardiovascular causes.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre

Mata-Cases

Prado-Lacueva

Salido-Valencia

et al. 2011

International Journal of Clinical Practice

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Prevalence and determinants of type 2 diabetes mellitus in a Greek adult population

et al. 2016

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Categories of glucose tolerance and continuous glycemic measures and mortality

et al. 2011

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We investigated the association of undiagnosed diabetes, previously known diabetes and prediabetes (WHO 1999 classification) with all-cause and cause-specific mortality in an older German population. Previous study results for mortality in patients with very low levels of HbA1c, fasting plasma glucose (FPG), and 2-h plasma glucose (2hPG) are still inconclusive. Thus we have extended the analyses to continuous measures of glycemia. A total of 1,466 subjects aged 55-74 years from the population-based KORA survey S4 (conducted from 1999 to 2001) were included in our observational mortality study (152 subjects with previously known diabetes, and 1,314 further subjects who underwent oral glucose tolerance tests). Mortality was followed up for a maximum of 10.0 years (median follow-up 8.8 years). A total of 180 (12.3%) of the 1,466 subjects have died during the follow-up period. The age- and sex-adjusted hazard ratios for all-cause mortality were 2.6 (95%CI, 1.7-3.8) for known diabetes, 2.8 (95%CI, 1.7-4.4) for undiagnosed diabetes, and 1.1 (95%CI, 0.8-1.7) for prediabetes [reference: normal glucose tolerance (NGT)]. After multivariable adjustment, undiagnosed diabetes was associated with 3.0-fold increased cancer mortality, 1.1-fold increased cardiovascular mortality, and 4.7-fold increased non-cancer, non-cardiovascular mortality compared with NGT. For HbA1c, FPG, and 2hPG, J-shaped associations with all-cause mortality were observed. Undiagnosed diabetes is associated with increased all-cause, cancer, and non-cancer non-cardiovascular mortality, but not with cardiovascular mortality in this older population. All-cause mortality in undiagnosed diabetes is similar to that in previously known diabetes but much higher than mortality in prediabetes and NGT.

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Riesgo de mortalidad en diabetes diagnosticada, diabetes no diagnosticada y prediabetes en población adulta española. Estudio Asturias 1998-2004

Cited by 28 publications

References 18 publications

Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre

Incidence of complications and mortality in a type 2 diabetes patient cohort study followed up from diagnosis in a primary healthcare centre

Prevalence and determinants of type 2 diabetes mellitus in a Greek adult population

Categories of glucose tolerance and continuous glycemic measures and mortality

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